Targeting the CCL2-CCR2 signaling pathway: potential implications of statins beyond cardiovascular diseases.
Hanieh GholamalizadehBehzad EnsanVasily N SukhorukovAmir Hossein SahebkarPublished in: The Journal of pharmacy and pharmacology (2023)
For the most part, statins play an inhibitory role on the CCL2-CCR2 axis which implies their potential to be further developed as therapeutic options in non-cardiovascular diseases either alone or in combination with other conventional treatments. However, the existing literature mostly focused on experimental models and is therefore inadequate to reach a conclusion.
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