Cannabinoid Receptor Activation on Haematopoietic Cells and Enterocytes Protects against Colitis.

William BeckerHaider Rasheed AlrafasPhilip B BusbeeMichael D WallaKiesha WilsonKathryn MirandaGuoshuai CaiVasanta PutluriNagireddy PutluriMitzi NagarkattiPrakash S Nagarkatti

Published in: Journal of Crohn's & colitis (2021)

Our findings demonstrate how cannabinoid receptor activation on both immune cells and colonocytes is critical to prevent colonic inflammation. These studies also suggest how cannabinoid receptor activation can be used as a preventive and therapeutic modality against colitis.

Keyphrases

induced apoptosis
oxidative stress
cell cycle arrest
signaling pathway
cell death
pi k akt