Apolipoprotein E polymorphism carriers exhibit objective cognitive deficits: a single center trial.

Yanfang ZengXin HuangKenneth B ElkinChristopher StoneGary B RajahLongfei GuanHuishan DuXiaokun Geng

Published in: Neurological research (2020)

The rate of the ε3/3 homozygous genotype was the highest, followed by the rates of the ε3/4 and ε2/3 genotypes. The rates of the ε2/4, ε4/4, and ε2/2 genotypes were the lowest. Deficits in memory and other cognitive processes were significantly more pronounced in ε4 carriers than in non-ε4 carriers.

Keyphrases

traumatic brain injury
clinical trial
study protocol
working memory
phase iii