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Genetic Polymorphisms of UDP-Glucuronosyltransferases and Susceptibility to Antituberculosis Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis.

Xinyu ChenZhuolu HaoNannan WangJia ZhuHonggang YiShao-Wen Tang
Published in: Journal of tropical medicine (2023)
The polymorphisms of UGT1A1 rs3755319, UGT2B7 rs7662029, and UGT2B7 rs7439366 were significantly associated with AT-DILI susceptibility. However, this conclusion should be interpreted with caution due to the low number of studies and the relatively small sample size.
Keyphrases
  • drug induced
  • case control
  • electronic health record