Insulin resistance disrupts white matter microstructure and amplitude of functional spontaneous activity in Bipolar disorder.

Elena MazzaFederico CalesellaMarco PaoliniCamilla di PasquasioSara PolettiCristina LorenziAndrea FaliniRaffaella ZanardiCristina ColomboFrancesco Benedetti

Published in: Bipolar disorders (2022)

Our findings suggest that WM microstructure and functional alterations might underlie the effect of IR on BD pathophysiology, even if the causal mechanisms need to be further investigated.

Keyphrases

white matter
bipolar disorder
insulin resistance
multiple sclerosis
major depressive disorder
adipose tissue
metabolic syndrome
polycystic ovary syndrome
skeletal muscle
mass spectrometry
resting state
high resolution
functional connectivity