Progressive Sarcopenia Correlates with Poor Response and Outcome to Immune Checkpoint Inhibitor Therapy.

Sven Heiko Loosen Vincent van den BoschJoao GorgulhoMaximilian Schulze-HagenJennis KandlerMarkus Sebastian Jördens Frank TackeChristina LobergGerald AntochTim Henrik BrümmendorfUlf P NeumannChristiane KuhlTom LueddeChristoph Roderburg

Published in: Journal of clinical medicine (2021)

Both progressive sarcopenia and an increasing skeletal muscle fat deposition are associated with poor response and outcome to ICI therapy, which might help to guide treatment decisions during ICI therapy.

Keyphrases

skeletal muscle
multiple sclerosis
adipose tissue
insulin resistance
stem cells
metabolic syndrome
combination therapy
community dwelling
bone marrow