Chronic heart failure with diabetes mellitus is characterized by a severe skeletal muscle pathology.

Jack O GarnhamLee D RobertsEver Espino-GonzalezAnna WhiteheadPeter P SwobodaAaron KoshyJohn GierulaMaria F PatonRichard M CubbonMark T KearneyStuart EggintonT Scott BowenKlaus K Witte

Published in: Journal of cachexia, sarcopenia and muscle (2019)

Patients with D-HF develop a specific skeletal muscle pathology, characterized by mitochondrial impairments, fibre atrophy, and derangements in the capillary network that are linked to exercise intolerance. These novel preliminary data support skeletal muscle as a potential therapeutic target for treating patients with D-HF.

Keyphrases

skeletal muscle
insulin resistance
oxidative stress
high intensity
electronic health record
physical activity
big data
type diabetes
metabolic syndrome
machine learning
resistance training
body composition
glycemic control
risk assessment
drug induced
data analysis
artificial intelligence