SMARCB1 Gene Therapy Using a Novel Tumor-Targeted Nanomedicine Enhances Anti-Cancer Efficacy in a Mouse Model of Atypical Teratoid Rhabdoid Tumors.

Sang-Soo KimManish MogheAntonina RaitKathryn DonaldsonJoe B HarfordEsther H Chang

Published in: International journal of nanomedicine (2024)

Collectively, our data suggest that restoring SMARCB1 function via the scL-SMARCB1 nanocomplex may lead to therapeutic benefits in ATRT patients when combined with traditional chemoradiation therapies.

Keyphrases

gene therapy
mouse model
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
cancer therapy
prognostic factors
rectal cancer
big data
data analysis
deep learning