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SMARCB1 Gene Therapy Using a Novel Tumor-Targeted Nanomedicine Enhances Anti-Cancer Efficacy in a Mouse Model of Atypical Teratoid Rhabdoid Tumors.

Sang-Soo KimManish MogheAntonina RaitKathryn DonaldsonJoe B HarfordEsther H Chang
Published in: International journal of nanomedicine (2024)
Collectively, our data suggest that restoring SMARCB1 function via the scL-SMARCB1 nanocomplex may lead to therapeutic benefits in ATRT patients when combined with traditional chemoradiation therapies.
Keyphrases
  • gene therapy
  • mouse model
  • end stage renal disease
  • newly diagnosed
  • ejection fraction
  • chronic kidney disease
  • cancer therapy
  • prognostic factors
  • rectal cancer
  • big data
  • data analysis
  • deep learning