Login / Signup

A new computational approach to estimate whole-brain effective connectivity from functional and structural MRI, applied to language development.

Gerald HahnMichael A SkeideDante MantiniMarco GanzettiAlain DestexheAngela D FriedericiGustavo Deco
Published in: Scientific reports (2019)
Recently introduced effective connectivity methods allow for the in-vivo investigation of large-scale functional interactions between brain regions. However, dynamic causal modeling, the most widely used technique to date, typically captures only a few predefined regions of interest. In this study, we present an alternative computational approach to infer effective connectivity within the entire connectome and show its performance on a developmental cohort with emerging language capacities. The novel approach provides new opportunities to quantify effective connectivity changes in the human brain.
Keyphrases
  • resting state
  • functional connectivity
  • white matter
  • autism spectrum disorder
  • multiple sclerosis
  • magnetic resonance imaging
  • contrast enhanced
  • computed tomography
  • magnetic resonance
  • cerebral ischemia