Discordant anti-SARS-CoV-2 spike protein and RNA staining in cutaneous perniotic lesions suggests endothelial deposition of cleaved spike protein.

Christine J KoMalini HarigopalJeffrey R GehlhausenMarcus BosenbergJennifer M McNiffWilliam Damsky

Published in: Journal of cutaneous pathology (2020)

While the gold standard for detection of SARS-CoV-2 in tissue sections has yet to be determined, the detection of SARS-CoV-2 SP alone without spike RNA suggests that cleaved SP may be present in cutaneous endothelial cells and eccrine epithelium, providing a potential pathogenetic mechanism of COVID-19 endotheliitis.

Keyphrases

sars cov
endothelial cells
respiratory syndrome coronavirus
loop mediated isothermal amplification
real time pcr
label free
protein protein
amino acid
binding protein
high glucose
quantum dots