A pharmacokinetic model of antiseizure medication load to guide care in the epilepsy monitoring unit.

Nina J Ghosn Kevin Xie Akash Ranjan PattnaikJames J GuggerColin A EllisElizabeth SweeneyEmily FoxJohn M BernabeiJenaye JohnsonJacqueline BoccanfusoBrian LittErin C Conrad

Published in: Epilepsia (2023)

A pharmacokinetic model can accurately estimate ASM levels for patients in the EMU. Lower modeled ASM levels are associated with increased seizure likelihood and seizure severity. We show that ASM load, rather than ASM taper speed, is associated with severe seizures. ASM modeling has the potential to help optimize taper strategy to minimize severe seizures while maximizing diagnostic yield.

Keyphrases

temporal lobe epilepsy
end stage renal disease
healthcare
ejection fraction
newly diagnosed
early onset
chronic kidney disease
prognostic factors
peritoneal dialysis
emergency department
patient reported outcomes
drug induced
risk assessment
adverse drug
human health
electronic health record