Alexander Hoffmann

Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 38

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Molecular systems biology

PNAS nexus

PLoS computational biology

Rockefeller University (PHD)

This page only lists publications with an associated author ORCID identifier.

Education History

Rockefeller University

United States

PHD

Publications

Stefanie Luecke, Xiaolu Guo, Katherine M Sheu, Apeksha Singh, Sarina C Lowe, Minhao Han, Jessica Diaz, Francisco J P Lopes, Roy Wollman, Alexander Hoffmann
Dynamical and combinatorial coding by MAPK p38 and NFκB in the inflammatory response of macrophages. Molecular systems biology 20 (8) (2024)
Stefanie Luecke, Xiaolu Guo, Katherine M Sheu, Apeksha Singh, Sarina C Lowe, Minhao Han, Jessica Diaz, Francisco J P Lopes, Roy Wollman, Alexander Hoffmann
Dynamical and combinatorial coding by MAPK p38 and NFκB in the inflammatory response of macrophages. Molecular systems biology (2024)
Helen Huang, Haripriya Vaidehi Narayanan, Alexander Hoffmann
Synergy and antagonism in the integration of BCR and CD40 signals that control B-cell proliferation. bioRxiv : the preprint server for biology (2024)
Helen Huang, Haripriya Vaidehi Narayanan, Alexander Hoffmann
Synergy and antagonism in the integration of BCR and CD40 signals that control B-cell proliferation. bioRxiv : the preprint server for biology (2024)
Haripriya Vaidehi Narayanan, Mark Y Xiang, Yijia Chen, Helen Huang, Sukanya Roy, Himani Makkar, Alexander Hoffmann, Koushik Roy
Direct observation correlates NFκB cRel in B cells with activating and terminating their proliferative program. Proceedings of the National Academy of Sciences of the United States of America 121 (30) (2024)
Haripriya Vaidehi Narayanan, Mark Y Xiang, Yijia Chen, Helen Huang, Sukanya Roy, Himani Makkar, Alexander Hoffmann, Koushik Roy
Direct observation correlates NFκB cRel in B cells with activating and terminating their proliferative program. Proceedings of the National Academy of Sciences of the United States of America 121 (30) (2024)
Stefanie Luecke, Xiaolu Guo, Katherine M Sheu, Apeksha Singh, Sarina C Lowe, Minhao Han, Jessica Diaz, Francisco J P Lopes, Roy Wollman, Alexander Hoffmann
Dynamical and combinatorial coding by MAPK p38 and NFκB in the inflammatory response of macrophages. Molecular systems biology 20 (8) (2024)
Haripriya Vaidehi Narayanan, Mark Y Xiang, Yijia Chen, Helen Huang, Sukanya Roy, Himani Makkar, Alexander Hoffmann, Koushik Roy
Direct observation correlates NFκB cRel in B cells with activating and terminating their proliferative program. Proceedings of the National Academy of Sciences of the United States of America 121 (30) (2024)
Haripriya Vaidehi Narayanan, Mark Y Xiang, Yijia Chen, Helen Huang, Sukanya Roy, Himani Makkar, Alexander Hoffmann, Koushik Roy
Direct observation correlates NFκB cRel in B cells with activating and terminating their proliferative program. Proceedings of the National Academy of Sciences of the United States of America 121 (30) (2024)
Jackson L Chin, Zhixin Cyrillus Tan, Liana C Chan, Felicia Ruffin, Rajesh Parmar, Richard Ahn, Scott D Taylor, Arnold S Bayer, Alexander Hoffmann, Vance G Fowler, Elaine F Reed, Michael R Yeaman, Aaron S Meyer, null null
Tensor modeling of MRSA bacteremia cytokine and transcriptional patterns reveals coordinated, outcome-associated immunological programs. PNAS nexus 3 (5) (2024)
Haripriya Vaidehi Narayanan, Mark Y Xiang, Yijia Chen, Helen Huang, Sukanya Roy, Himani Makkar, Alexander Hoffmann, Koushik Roy
Direct observation correlates NFκB cRel in B cells with activating and terminating their proliferative program. Proceedings of the National Academy of Sciences of the United States of America 121 (30) (2024)
Benancio N Rodriguez, Helen Huang, Jennifer J Chia, Alexander Hoffmann
The noncanonical NFκB pathway: Regulatory mechanisms in health and disease. WIREs mechanisms of disease (2024)
Stefanie Luecke, Xiaolu Guo, Katherine M Sheu, Apeksha Singh, Sarina C Lowe, Minhao Han, Jessica Diaz, Francisco J P Lopes, Roy Wollman, Alexander Hoffmann
Dynamical and combinatorial coding by MAPK p38 and NFκB in the inflammatory response of macrophages. Molecular systems biology 20 (8) (2024)
Stefanie Luecke, Xiaolu Guo, Katherine M Sheu, Apeksha Singh, Sarina C Lowe, Minhao Han, Jessica Diaz, Francisco J P Lopes, Roy Wollman, Alexander Hoffmann
Dynamical and combinatorial coding by MAPK p38 and NFκB in the inflammatory response of macrophages. Molecular systems biology 20 (8) (2024)
Jingzhou Zhang, Justin Griffin, Koushik Roy, Alexander Hoffmann, Thomas A Zangle
Tracking of lineage mass via quantitative phase imaging and confinement in low refractive index microwells. Lab on a chip (2024)
Jackson L Chin, Zhixin Cyrillus Tan, Liana C Chan, Felicia Ruffin, Rajesh Parmar, Richard Ahn, Scott D Taylor, Arnold S Bayer, Alexander Hoffmann, Vance G Fowler, Elaine F Reed, Michael R Yeaman, Aaron S Meyer, null null
Tensor modeling of MRSA bacteremia cytokine and transcriptional patterns reveals coordinated, outcome-associated immunological programs. PNAS nexus 3 (5) (2024)
Jackson L Chin, Zhixin Cyrillus Tan, Liana C Chan, Felicia Ruffin, Rajesh Parmar, Richard Ahn, Scott D Taylor, Arnold S Bayer, Alexander Hoffmann, Vance G Fowler, Elaine F Reed, Michael R Yeaman, Aaron S Meyer, null null
Tensor modeling of MRSA bacteremia cytokine and transcriptional patterns reveals coordinated, outcome-associated immunological programs. PNAS nexus 3 (5) (2024)
Alexander Hoffmann
Designer genes courtesy of artificial intelligence. Genes & development (2023)
Simon Mitchell, Rachel Tsui, Zhixin Cyrillus Tan, Arran Pack, Alexander Hoffmann
The NF-κB multidimer system model: A knowledge base to explore diverse biological contexts. Science signaling 16 (776) (2023)
Simon Mitchell, Rachel Tsui, Zhixin Cyrillus Tan, Arran Pack, Alexander Hoffmann
The NF-κB multidimer system model: A knowledge base to explore diverse biological contexts. Science signaling 16 (776) (2023)
Stefanie Luecke, Adewunmi Adelaja, Xiaolu Guo, Supriya Sen, Philip Lsm Gordts, Apeksha Singh, Yi Liu, Brooks Taylor, Jessica Diaz, Quen Cheng, Alexander Hoffmann
Tonic TNF conditioning of macrophages safeguards stimulus-specific inflammatory responses. EMBO reports (2023)
Catera L Wilder, Diane Lefaudeux, Raisa Mathenge, Kensei Kishimoto, Alma Zuniga Munoz, Minh A Nguyen, Aaron S Meyer, Quen J Cheng, Alexander Hoffmann
A stimulus-contingent positive feedback loop enables IFN-β dose-dependent activation of pro-inflammatory genes. Molecular systems biology (2023)
Marie Oliver Metzig, Alexander Hoffmann
Controlling Cancer Cell Death Types to Optimize Anti-Tumor Immunity. Biomedicines 10 (5) (2022)
Ying Tang, Alexander Hoffmann
Quantifying information of intracellular signaling: progress with machine learning. Reports on progress in physics. Physical Society (Great Britain) 85 (8) (2022)
Minami Ando, Shigeyuki Magi, Masahide Seki, Yutaka Suzuki, Takeya Kasukawa, Diane Lefaudeux, Alexander Hoffmann, Mariko Okada
Author Correction: IκBα is required for full transcriptional induction of some NFκB-regulated genes in response to TNF in MCF-7 cells. NPJ systems biology and applications 8 (1) (2022)
Diane Lefaudeux, Supriya Sen, Kevin Jiang, Alexander Hoffmann, null null
Kinetics of mRNA nuclear export regulate innate immune response gene expression. Nature communications 13 (1) (2022)
Minami Ando, Shigeyuki Magi, Masahide Seki, Yutaka Suzuki, Takeya Kasukawa, Diane Lefaudeux, Alexander Hoffmann, Mariko Okada
IκBα is required for full transcriptional induction of some NFκB-regulated genes in response to TNF in MCF-7 cells. NPJ systems biology and applications 7 (1) (2021)
Ying Tang, Adewunmi Adelaja, Felix X-F Ye, Eric J Deeds, Roy Wollman, Alexander Hoffmann
Quantifying information accumulation encoded in the dynamics of biochemical signaling. Nature communications 12 (1) (2021)
Quen J Cheng, Sho Ohta, Katherine M Sheu, Philip Lsm Gordts, Adewunmi Adelaja, Brooks Taylor, Alexander Hoffmann
NF-κB dynamics determine the stimulus specificity of epigenomic reprogramming in macrophages. Science (New York, N.Y.) 372 (6548) (2021)
Yu-Ling Chang, Maura Rossetti, David W Gjertson, Liudmilla Rubbi, Michael J Thompson, Dennis J Montoya, Marco Morselli, Felicia Ruffin, Alexander Hoffmann, Matteo Pellegrini, Vance G Fowler, Michael R Yeaman, Elaine F Reed, null null
Human DNA methylation signatures differentiate persistent from resolving MRSA bacteremia. Proceedings of the National Academy of Sciences of the United States of America 118 (10) (2021)
Marie Oliver Metzig, Ying Tang, Simon Mitchell, Brooks Taylor, Robert Foreman, Roy Wollman, Alexander Hoffmann
An incoherent feedforward loop interprets NFκB/RelA dynamics to determine TNF-induced necroptosis decisions. Molecular systems biology 16 (12) (2021)
Ning Wang, Diane Lefaudeux, Anup Mazumder, Jingyi Jessica Li, Alexander Hoffmann
Identifying the combinatorial control of signal-dependent transcription factors. PLoS computational biology 17 (6) (2021)
Dominique N Lisiero, Zhang Cheng, Melba M Tejera, Brandon T Neldner, Jay W Warrick, Shelly M Wuerzberger-Davis, Alexander Hoffmann, Marulasiddappa Suresh, Shigeki Miyamoto
IκBα Nuclear Export Enables 4-1BB-Induced cRel Activation and IL-2 Production to Promote CD8 T Cell Immunity. Journal of immunology (Baltimore, Md. : 1950) 205 (6) (2020)
Tsuyoshi Mikkaichi, Michael R Yeaman, Alexander Hoffmann, null null
Identifying determinants of persistent MRSA bacteremia using mathematical modeling. PLoS computational biology 15 (7) (2019)
Simon Mitchell, Alexander Hoffmann
Substrate complex competition is a regulatory motif that allows NFκB RelA to license but not amplify NFκB RelB. Proceedings of the National Academy of Sciences of the United States of America 116 (21) (2019)
Simon Mitchell, Koushik Roy, Thomas A Zangle, Alexander Hoffmann
Nongenetic origins of cell-to-cell variability in B lymphocyte proliferation. Proceedings of the National Academy of Sciences of the United States of America 115 (12) (2018)
Kyu-Hyeon Yeom, Simon Mitchell, Anthony J Linares, Sika Zheng, Chia-Ho Lin, Xiao-Jun Wang, Alexander Hoffmann, Douglas L Black
Polypyrimidine tract-binding protein blocks miRNA-124 biogenesis to enforce its neuronal-specific expression in the mouse. Proceedings of the National Academy of Sciences of the United States of America 115 (47) (2018)
Wen-Hsien Liu, Seung Goo Kang, Zhe Huang, Cheng-Jang Wu, Hyun Yong Jin, Christian J Maine, Yi C Liu, Jovan Shepherd, Mohsen Sabouri-Ghomi, Alicia Gonzalez-Martin, Shunbin Xu, Alexander Hoffmann, Ye Zheng, Li-Fan Lu, Nengming Xiao, Guo Fu, Changchun Xiao
A miR-155-Peli1-c-Rel pathway controls the generation and function of T follicular helper cells. The Journal of experimental medicine 213 (9) (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

Alexander Hoffmann