Synergy and antagonism in the integration of BCR and CD40 signals that control B-cell proliferation.

CD40 and BCR signaling in B-cells synergize to potentiate NFκB cRel activationBCR-apoptotic signaling may enhance or antagonize CD40-driven proliferationBCR-induced apoptosis may be rescued by CD40 within a temporal windowA mathematical model reveals regulators of the dose-dependent selection stringency.