Bruno G De Geest

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 41

Top Topics

Hyaluronic Acid

Top Venues

Angewandte Chemie (International ed. in English)

Journal of the American Chemical Society

Bioconjugate chemistry

Biomacromolecules

This page only lists publications with an associated author ORCID identifier.

Publications

Elias Denijs, Kamil Unal, Kevin Bevernaege, Sabah Kasmi, Bruno G De Geest, Johan M Winne
Thermally Triggered Triazolinedione-Tyrosine Bioconjugation with Improved Chemo- and Site-Selectivity. Journal of the American Chemical Society (2024)
Haixia Peng, Steven Martens, Annemiek Uvyn, Yong Chen, Zifu Zhong, Benoit Louage, Bruno G De Geest
Exploration of Solid Phase Peptoid Synthesis for the Design of Trifunctional Hapten-Lipid-TLR7/8 Agonist Antibody-Recruiting Oligomers That Combine Innate Effector with Innate Activation Function. ACS applied bio materials (2024)
Elias Denijs, Kamil Unal, Kevin Bevernaege, Sabah Kasmi, Bruno G De Geest, Johan M Winne
Thermally Triggered Triazolinedione-Tyrosine Bioconjugation with Improved Chemo- and Site-Selectivity. Journal of the American Chemical Society 146 (18) (2024)
Alexander Lamoot, Sonia Jangra, Gabriel Laghlali, Prajakta Warang, Gagandeep Singh, Lauren A Chang, Seok-Chan Park, Gagandeep Singh, Kim De Swarte, Zifu Zhong, Benoit Louage, Emily De Lombaerde, Tingting Ye, Yong Chen, Sara Cuadrado-Castano, Stefan Lienenklaus, Niek N Sanders, Bart N Lambrecht, Adolfo García-Sastre, Michael Schotsaert, Bruno G De Geest
Lipid Nanoparticle Encapsulation Empowers Poly(I:C) to Activate Cytoplasmic RLRs and Thereby Increases Its Adjuvanticity. Small (Weinheim an der Bergstrasse, Germany) (2023)
Alexander Lamoot, Joris Lammens, Emily De Lombaerde, Zifu Zhong, Mark Gontsarik, Yong Chen, Thomas R M De Beer, Bruno G De Geest
Successful batch and continuous lyophilization of mRNA LNP formulations depend on cryoprotectants and ionizable lipids. Biomaterials science (2023)
Zifu Zhong, Yong Chen, Kim Deswarte, Heleen Lauwers, Emily De Lombaerde, Xiaole Cui, Simon Van Herck, Tingting Ye, Mark Gontsarik, Stefan Lienenklaus, Niek N Sanders, Bart N Lambrecht, Stefaan De Koker, Bruno G De Geest
Lipid Nanoparticle Delivery Alters The Adjuvanticity of The TLR9 Agonist Cpg by Innate Immune Activation in Lymphoid Tissue. Advanced healthcare materials (2023)
Resat Aksakal, Corentin Tonneaux, Annemiek Uvyn, Mathieu Fossépré, Hatice Turgut, Nezha Badi, Mathieu Surin, Bruno G De Geest, Filip E Du Prez
Sequence-defined antibody-recruiting macromolecules. Chemical science 14 (24) (2023)
Annemiek Uvyn, Marle Vleugels, Bas de Waal, Ahmed Emad Ibrahim Hamouda, Shikha Dhiman, Benoit Louage, Lorenzo Albertazzi, Damya Laoui, E W Meijer, Bruno G De Geest
Hapten/Myristoyl Functionalized Poly(Propylene IMINE) Dendrimers as Potent Cell Surface Recruiters of Antibodies for Mediating Innate Immune Killing. Advanced materials (Deerfield Beach, Fla.) (2023)
Yanyun Hao, Hui Li, Huajun Zhao, Yutong Liu, Xiaoyan Ge, Xia Li, Hongfei Chen, Ailu Yang, Jing Zou, Xue Li, Xuechun Sun, Xinke Zhang, Xiao Wang, Zepeng Li, Qilu Zhang, Hao Wu, Guan Wang, Jian Zhang, Bruno G De Geest, Zhiyue Zhang
An Intelligent Nanovehicle Armed with Multifunctional Navigation for Precise Delivery of Toll-Like Receptor 7/8 Agonist and Immunogenic Cell Death Amplifiers to Eliminate Solid Tumors and Trigger Durable Antitumor Immunity. Advanced healthcare materials 11 (12) (2022)
Leonard Kaps, Anne Huppertsberg, Niklas Choteschovsky, Adrian Klefenz, Feyza Durak, Barbara Schrörs, Mustafa Diken, Emma Eichler, Sebastian Rosigkeit, Sascha Schmitt, Christian Leps, Alicia Poplawski, Friedrich Förster, Ernesto Bockamp, Bruno G De Geest, Kaloian Koynov, Hans-Joachim Räder, Stefan Tenzer, Federico Marini, Detlef Schuppan, Lutz Nuhn
pH-degradable, bisphosphonate-loaded nanogels attenuate liver fibrosis by repolarization of M2-type macrophages. Proceedings of the National Academy of Sciences of the United States of America 119 (12) (2022)
Anne Huppertsberg, Leonard Kaps, Zifu Zhong, Sascha Schmitt, Judith Stickdorn, Kim Deswarte, Francis Combes, Christian Czysch, Jana De Vrieze, Sabah Kasmi, Niklas Choteschovsky, Adrian Klefenz, Carolina Medina-Montano, Pia Winterwerber, Chaojian Chen, Matthias Bros, Stefan Lienenklaus, Xiaole Cui, Kaloian Koynov, Detlef Schuppan, Bart N Lambrecht, Sunil A David, Bruno G De Geest, Lutz Nuhn
Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-like Receptor 7/8 Agonistic Immune Modulators. Journal of the American Chemical Society 143 (26) (2021)
Alexander Lamoot, Annemiek Uvyn, Sabah Kasmi, Bruno G De Geest
Covalent Cell Surface Conjugation of Nanoparticles by a Combination of Metabolic Labeling and Click Chemistry. Angewandte Chemie (International ed. in English) 60 (12) (2021)
Sonia Jangra, Jana De Vrieze, Angela Choi, Raveen Rathnasinghe, Gabriel Laghlali, Annemiek Uvyn, Simon Van Herck, Lutz Nuhn, Kim Deswarte, Zifu Zhong, Niek N Sanders, Stefan Lienenklaus, Sunil A David, Shirin Strohmeier, Fatima Amanat, Florian Krammer, Hamida Hammad, Bart N Lambrecht, Lynda Coughlan, Adolfo García-Sastre, Bruno G De Geest, Michael Schotsaert
Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine*. Angewandte Chemie (International ed. in English) 60 (17) (2021)
Dorien Van Lysebetten, Alessio Malfanti, Kim Deswarte, Kaloian Koynov, Bianka Golba, Tingting Ye, Zifu Zhong, Sabah Kasmi, Alexander Lamoot, Yong Chen, Simon Van Herck, Bart N Lambrecht, Xiaole Cui, Stefan Lienenklaus, Sunil A David, María Jesus Vicent, Stefaan De Koker, Bruno G De Geest
Lipid-Polyglutamate Nanoparticle Vaccine Platform. ACS applied materials & interfaces 13 (5) (2021)
Johannes Kockelmann, Judith Stickdorn, Sabah Kasmi, Jana De Vrieze, Michaela Pieszka, David Yuen Wah Ng, Sunil A David, Bruno G De Geest, Lutz Nuhn
Control over Imidazoquinoline Immune Stimulation by pH-Degradable Poly(norbornene) Nanogels. Biomacromolecules 21 (6) (2020)
Madiha Saeed, Zhiai Xu, Bruno G De Geest, Huixiong Xu, Haijun Yu
Molecular Imaging for Cancer Immunotherapy: Seeing Is Believing. Bioconjugate chemistry 31 (2) (2020)
Ruben De Coen, Lutz Nuhn, Chamani Perera, Maria Arista-Romero, Martijn D P Risseeuw, Alec Freyn, Raffael Nachbagauer, Lorenzo Albertazzi, Serge Van Calenbergh, David Adam Spiegel, Blake R Peterson, Bruno G De Geest
Synthetic Rhamnose Glycopolymer Cell-Surface Receptor for Endogenous Antibody Recruitment. Biomacromolecules 21 (2) (2020)
Yong Chen, Stefaan De Koker, Bruno G De Geest
Correction to Engineering Strategies for Lymph Node Targeted Immune Activation. Accounts of chemical research 53 (12) (2020)
Yong Chen, Stefaan De Koker, Bruno G De Geest
Engineering Strategies for Lymph Node Targeted Immune Activation. Accounts of chemical research 53 (10) (2020)
Hui Li, Simon Van Herck, Yongjun Liu, Yanyun Hao, Xiaochu Ding, Lutz Nuhn, Zifu Zhong, Francis Combes, Xiaole Cui, Stefan Lienenklaus, Stefaan D Koker, Sunil A David, Yadong Wang, Bruno G De Geest, Zhiyue Zhang
Imidazoquinoline-Conjugated Degradable Coacervate Conjugate for Local Cancer Immunotherapy. ACS biomaterials science & engineering 6 (9) (2020)
Jana De Vrieze, Simon Van Herck, Lutz Nuhn, Bruno G De Geest
Design of pH-Degradable Polymer-Lipid Amphiphiles Using a Ketal-Functionalized RAFT Chain Transfer Agent. Macromolecular rapid communications 41 (18) (2020)
Tingting Ye, Zifu Zhong, Adolfo García-Sastre, Michael Schotsaert, Bruno G De Geest
Current Status of COVID-19 (Pre)Clinical Vaccine Development. Angewandte Chemie (International ed. in English) 59 (43) (2020)
Yann Bernhard, Ondrej Sedlacek, Joachim F R Van Guyse, Johan Bender, Zifu Zhong, Bruno G De Geest, Richard Hoogenboom
Poly(2-ethyl-2-oxazoline) Conjugates with Salicylic Acid via Degradable Modular Ester Linkages. Biomacromolecules 21 (8) (2020)
Bi Wang, Simon Van Herck, Yong Chen, Xiangyang Bai, Zifu Zhong, Kim Deswarte, Bart N Lambrecht, Xiaole Cui, Stefan Lienenklaus, Hans W Scheeren, Sunil A David, Fabian Kießling, Twan Lammers, Bruno G De Geest, Yang Shi
Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles. Journal of the American Chemical Society 142 (28) (2020)
Ondrej Sedlacek, Kathleen Lava, Bart Verbraeken, Sabah Kasmi, Bruno G De Geest, Richard Hoogenboom
Unexpected Reactivity Switch in the Statistical Copolymerization of 2-Oxazolines and 2-Oxazines Enabling the One-Step Synthesis of Amphiphilic Gradient Copolymers. Journal of the American Chemical Society 141 (24) (2019)
Zhiyue Zhang, Hui Li, Sabah Kasmi, Simon Van Herck, Kim Deswarte, Bart N Lambrecht, Richard Hoogenboom, Lutz Nuhn, Bruno G De Geest
A Synthetic, Transiently Thermoresponsive Homopolymer with UCST Behaviour within a Physiologically Relevant Window. Angewandte Chemie (International ed. in English) 58 (23) (2019)
Annemiek Uvyn, Ruben De Coen, Mandy Gruijs, Cees W Tuk, Jana De Vrieze, Marjolein van Egmond, Bruno G De Geest
Efficient Innate Immune Killing of Cancer Cells Triggered by Cell-Surface Anchoring of Multivalent Antibody-Recruiting Polymers. Angewandte Chemie (International ed. in English) 58 (37) (2019)
Jana De Vrieze, Benoit Louage, Kim Deswarte, Zifu Zhong, Ruben De Coen, Simon Van Herck, Lutz Nuhn, Camilla Kaas Frich, Alexander N Zelikin, Stefan Lienenklaus, Niek N Sanders, Bart N Lambrecht, Sunil A David, Bruno G De Geest
Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists. Angewandte Chemie (International ed. in English) 58 (43) (2019)
Shuang Zhao, Frank Caruso, Lars Dähne, Gero Decher, Bruno G De Geest, JinChen Fan, Neus Feliu, Yury Gogotsi, Paula T Hammond, Mark C Hersam, Ali Khademhosseini, Nicholas A Kotov, Stefano Leporatti, Yan Li, Fred Lisdat, Luis M Liz-Marzán, Sergio Enrique Moya, Paul A Mulvaney, Andrey L Rogach, Sathi Roy, Dmitry G Shchukin, André G Skirtach, Molly M Stevens, Gleb B Sukhorukov, Paul S Weiss, Zhao Yue, Dingcheng Zhu, Wolfgang J Parak
The Future of Layer-by-Layer Assembly: A Tribute to ACS Nano Associate Editor Helmuth Möhwald. ACS nano 13 (6) (2019)
Simon Van Herck, Kim Deswarte, Lutz Nuhn, Zifu Zhong, Joao Paulo Portela Catani, Yupeng Li, Xiaole Cui, Stefan Lienenklaus, Stefaan De Koker, Bart N Lambrecht, Sunil A David, Bruno G De Geest
Lymph-Node-Targeted Immune Activation by Engineered Block Copolymer Amphiphiles-TLR7/8 Agonist Conjugates. Journal of the American Chemical Society 140 (43) (2018)
Lutz Nuhn, Stefaan De Koker, Sandra Van Lint, Zifu Zhong, João Portela Catani, Francis Combes, Kim Deswarte, Yupeng Li, Bart N Lambrecht, Stefan Lienenklaus, Niek N Sanders, Sunil A David, Jan Tavernier, Bruno G De Geest
Nanoparticle-Conjugate TLR7/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses. Advanced materials (Deerfield Beach, Fla.) 30 (45) (2018)
Lutz Nuhn, Evangelia Bolli, Sam Massa, Isabel Vandenberghe, Kiavash Movahedi, Bart Devreese, Jo A Van Ginderachter, Bruno G De Geest
Targeting Protumoral Tumor-Associated Macrophages with Nanobody-Functionalized Nanogels through Strain Promoted Azide Alkyne Cycloaddition Ligation. Bioconjugate chemistry 29 (7) (2018)
Federico Fenaroli, Urska Repnik, Yitian Xu, Kerstin Johann, Simon Van Herck, Pradip Dey, Frode Miltzov Skjeldal, Dominik M Frei, Shahla Bagherifam, Agnese Kocere, Rainer Haag, Bruno G De Geest, Matthias Barz, David G Russell, Gareth Griffiths
Enhanced Permeability and Retention-like Extravasation of Nanoparticles from the Vasculature into Tuberculosis Granulomas in Zebrafish and Mouse Models. ACS nano 12 (8) (2018)
Euna Yoo, Alex C D Salyer, Michael J H Brush, Yupeng Li, Kathryn L Trautman, Nikunj M Shukla, Ans De Beuckelaer, Stefan Lienenklaus, Kim Deswarte, Bart N Lambrecht, Bruno G De Geest, Sunil A David
Hyaluronic Acid Conjugates of TLR7/8 Agonists for Targeted Delivery to Secondary Lymphoid Tissue. Bioconjugate chemistry 29 (8) (2018)
Lutz Nuhn, Simon Van Herck, Andreas Best, Kim Deswarte, Maria Kokkinopoulou, Ingo Lieberwirth, Kaloian Koynov, Bart N Lambrecht, Bruno G De Geest
FRET Monitoring of Intracellular Ketal Hydrolysis in Synthetic Nanoparticles. Angewandte Chemie (International ed. in English) 57 (33) (2018)
Nane Vanparijs, Lutz Nuhn, Bruno G De Geest
Transiently thermoresponsive polymers and their applications in biomedicine. Chemical Society reviews 46 (4) (2018)
Simon Van Herck, Lien Van Hoecke, Benoit Louage, Lien Lybaert, Ruben De Coen, Sabah Kasmi, Aaron P Esser Kahn, Sunil A David, Lutz Nuhn, Bert Schepens, Xavier Saelens, Bruno G De Geest
Transiently Thermoresponsive Acetal Polymers for Safe and Effective Administration of Amphotericin B as a Vaccine Adjuvant. Bioconjugate chemistry 29 (3) (2017)
Benoit Louage, Mies J van Steenbergen, Lutz Nuhn, Martijn D P Risseeuw, Izet Karalic, Johan Winne, Serge Van Calenbergh, Wim E Hennink, Bruno G De Geest
Micellar Paclitaxel-Initiated RAFT Polymer Conjugates with Acid-Sensitive Behavior. ACS macro letters 6 (3) (2017)
Diana G Ramírez-Wong, Saghi Saghazadeh, Simon Van Herck, Bruno G De Geest, Alain M Jonas, Sophie Demoustier-Champagne
Uptake of Long Protein-Polyelectrolyte Nanotubes by Dendritic Cells. Biomacromolecules 18 (12) (2017)
Stef Vandewalle, Ruben De Coen, Bruno G De Geest, Filip E Du Prez
Tyrosine-Triazolinedione Bioconjugation as Site-Selective Protein Modification Starting from RAFT-Derived Polymers. ACS macro letters 6 (12) (2017)
Shuhao Zhang, Carolin Bisterfeld, Julia Bramski, Nane Vanparijs, Bruno G De Geest, Jörg Pietruszka, Alexander Böker, Stefan Reinicke
Biocatalytically Active Thin Films via Self-Assembly of 2-Deoxy-d-ribose-5-phosphate Aldolase-Poly(N-isopropylacrylamide) Conjugates. Bioconjugate chemistry 29 (1) (2017)