Caren L Freel Meyers

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 23

Top Venues

Biochemistry

ACS infectious diseases

Antibiotics (Basel, Switzerland)

Accounts of chemical research

Johns Hopkins School of Medicine

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Johns Hopkins School of Medicine Sep 01 2005

United States

Associate Professor :: Pharmacology and Molecular Sciences

Publications

Lauren B Coco, Eucolona M Toci, Percival Yang-Ting Chen, Catherine L Drennan, Caren L Freel Meyers
Potent Inhibition of E. coli DXP Synthase by a gem -Diaryl Bisubstrate Analog. ACS infectious diseases 10 (4) (2024)
Eucolona M Toci, Steven L Austin, Ananya Majumdar, H Lee Woodcock, Caren L Freel Meyers
Disruption of an Active Site Network Leads to Activation of C2α-Lactylthiamin Diphosphate on the Antibacterial Target 1-Deoxy-d-xylulose-5-phosphate Synthase. Biochemistry 63 (5) (2024)
Eucolona M Toci, Steven L Austin, Ananya Majumdar, H Lee Woodcock, Caren L Freel Meyers
Disruption of an Active Site Network Leads to Activation of C2α-Lactylthiamin Diphosphate on the Antibacterial Target 1-Deoxy-d-xylulose-5-phosphate Synthase. Biochemistry 63 (5) (2024)
Eucolona M Toci, Steven L Austin, Ananya Majumdar, H Lee Woodcock, Caren L Freel Meyers
Disruption of an Active Site Network Leads to Activation of C2α-Lactylthiamin Diphosphate on the Antibacterial Target 1-Deoxy-d-xylulose-5-phosphate Synthase. Biochemistry (2024)
Lauren B Coco, Eucolona M Toci, Percival Yang-Ting Chen, Catherine L Drennan, Caren L Freel Meyers
Potent Inhibition of E. coli DXP Synthase by a gem -Diaryl Bisubstrate Analog. ACS infectious diseases 10 (4) (2024)
Eucolona M Toci, Steven L Austin, Ananya Majumdar, H Lee Woodcock, Caren L Freel Meyers
Disruption of an Active Site Network Leads to Activation of C2α-Lactylthiamin Diphosphate on the Antibacterial Target 1-Deoxy-d-xylulose-5-phosphate Synthase. Biochemistry 63 (5) (2024)
Lauren B Coco, Eucolona M Toci, Percival Yang-Ting Chen, Catherine L Drennan, Caren L Freel Meyers
Potent Inhibition of E. coli DXP Synthase by a gem -Diaryl Bisubstrate Analog. ACS infectious diseases (2024)
Lauren B Coco, Eucolona M Toci, Percival Yang-Ting Chen, Catherine L Drennan, Caren L Freel Meyers
Potent Inhibition of E. coli DXP Synthase by a gem -Diaryl Bisubstrate Analog. ACS infectious diseases 10 (4) (2024)
Lauren B Coco, Eucolona M Toci, Percival Yang-Ting Chen, Catherine L Drennan, Caren L Freel Meyers
Potent Inhibition of E. coli DXP Synthase by a gem -Diaryl Bisubstrate Analog. ACS infectious diseases 10 (4) (2024)
Eucolona M Toci, Steven L Austin, Ananya Majumdar, H Lee Woodcock, Caren L Freel Meyers
Disruption of an Active Site Network Leads to Activation of C2α-Lactylthiamin Diphosphate on the Antibacterial Target 1-Deoxy-d-xylulose-5-phosphate Synthase. Biochemistry 63 (5) (2024)
Lauren B Coco, Eucolona M Toci, Percival Yang-Ting Chen, Catherine L Drennan, Caren L Freel Meyers
Potent Inhibition of E. coli DXP Synthase by a gem -Diaryl Bisubstrate Analog. ACS infectious diseases 10 (4) (2024)
Lauren B Coco, Eucolona M Toci, Percival Yang-Ting Chen, Catherine L Drennan, Caren L Freel Meyers
Potent Inhibition of E. coli DXP Synthase by a gem -Diaryl Bisubstrate Analog. ACS infectious diseases 10 (4) (2024)
Eric C Chen, Caren L Freel Meyers
DXP Synthase Function in a Bacterial Metabolic Adaptation and Implications for Antibacterial Strategies. Antibiotics (Basel, Switzerland) 12 (4) (2023)
Paul Curley, James J Hobson, Neill J Liptrott, Edward Makarov, Amer Al-Khouja, Lee Tatham, Christopher A W David, Helen Box, Megan Neary, Joanne Sharp, Henry Pertinez, David Meyers, Charles Flexner, Caren L Freel Meyers, Larisa Y Poluektova, Steve Rannard, Andrew Owen
Preclinical Evaluation of Long-Acting Emtricitabine Semi-Solid Prodrug Nanoparticle Formulations. Pharmaceutics 15 (7) (2023)
Eric C Chen, Caren L Freel Meyers
DXP Synthase Function in a Bacterial Metabolic Adaptation and Implications for Antibacterial Strategies. Antibiotics (Basel, Switzerland) 12 (4) (2023)
Melanie L Johnston, Eucolona M Bonett, Alicia A DeColli, Caren L Freel Meyers
Antibacterial Target DXP Synthase Catalyzes the Cleavage of d-Xylulose 5-Phosphate: a Study of Ketose Phosphate Binding and Ketol Transfer Reaction. Biochemistry 61 (17) (2022)
Melanie L Johnston, Caren L Freel Meyers
Revealing Donor Substrate-Dependent Mechanistic Control on DXPS, an Enzyme in Bacterial Central Metabolism. Biochemistry 60 (12) (2021)
Alicia A DeColli, Xu Zhang, Kathryn L Heflin, Frank Jordan, Caren L Freel Meyers
Active Site Histidines Link Conformational Dynamics with Catalysis on Anti-Infective Target 1-Deoxy-d-xylulose 5-Phosphate Synthase. Biochemistry 58 (49) (2019)
David Bartee, Sara Sanders, Paul D Phillips, Mackenzie J Harrison, Andrew T Koppisch, Caren L Freel Meyers
Enamide Prodrugs of Acetyl Phosphonate Deoxy-d-xylulose-5-phosphate Synthase Inhibitors as Potent Antibacterial Agents. ACS infectious diseases 5 (3) (2019)
David Bartee, Caren L Freel Meyers
Toward Understanding the Chemistry and Biology of 1-Deoxy-d-xylulose 5-Phosphate (DXP) Synthase: A Unique Antimicrobial Target at the Heart of Bacterial Metabolism. Accounts of chemical research 51 (10) (2018)
David Bartee, Michael J Wheadon, Caren L Freel Meyers
Synthesis and Evaluation of Fluoroalkyl Phosphonyl Analogues of 2- C-Methylerythritol Phosphate as Substrates and Inhibitors of IspD from Human Pathogens. The Journal of organic chemistry 83 (17) (2018)
David Bartee, Caren L Freel Meyers
Targeting the Unique Mechanism of Bacterial 1-Deoxy-d-xylulose-5-phosphate Synthase. Biochemistry 57 (29) (2018)
Sara Sanders, Ryan J Vierling, David Bartee, Alicia A DeColli, Mackenzie J Harrison, Joseph L Aklinski, Andrew T Koppisch, Caren L Freel Meyers
Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-d-xylulose 5-Phosphate Synthase. ACS infectious diseases 3 (7) (2017)

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Publication Activity (10 Years)

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Caren L Freel Meyers