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David J Thornton (David Thornton, D J Thornton)

Scopus Author ID Scopus Author ID Scopus Author ID Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2016-2022
Publications (10 Years): 20

Top Venues

Nature communications

The Journal of biological chemistry

PLoS pathogens

Proceedings of the National Academy of Sciences of the United States of America

University of Manchester

Lancaster University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Manchester Aug 1o 2011

United Kingdom

Professor of Biochemistry :: Faculty of Biology, Medicine and Health

Education History

Lancaster University Oct 1o 1980 - Jan 31o 1984

United Kingdom

PHD :: Biological Sciences

Publications

María A Duque-Correa, David Goulding, Faye H Rodgers, J Andrew Gillis, Claire Cormie, Kate A Rawlinson, Allison J Bancroft, Hayley M Bennett, Magda E Lotkowska, Adam J Reid, Anneliese O Speak, Paul Scott, Nicholas Redshaw, Charlotte Tolley, Catherine McCarthy, Cordelia Brandt, Catherine Sharpe, Caroline Ridley, Judit Gali Moya, Claudia Martins Carneiro, Tobias Starborg, Kelly S Hayes, Nancy Holroyd, Mandy Sanders, David J Thornton, Richard K Grencis, Matthew Berriman
Defining the early stages of intestinal colonisation by whipworms. Nature communications 13 (1) (2022)
Jerome Carpenter, Yang Wang, Richa Gupta, Yuanli Li, Prashamsha Haridass, Durai B Subramani, Boris Reidel, Lisa Morton, Caroline Ridley, Wanda K O'Neal, Marie-Pierre Buisine, Camille Ehre, David J Thornton, Mehmet Kesimer
Assembly and organization of the N-terminal region of mucin MUC5AC: Indications for structural and functional distinction from MUC5B. Proceedings of the National Academy of Sciences of the United States of America 118 (39) (2021)
Leslie E Morgan, Ana M Jaramillo, Siddharth K Shenoy, Dorota Raclawska, Nkechinyere A Emezienna, Vanessa L Richardson, Naoko Hara, Anna Q Harder, James C NeeDell, Corinne E Hennessy, Hassan M El-Batal, Chelsea M Magin, Diane E Grove Villalon, Gregg A Duncan, Justin S Hanes, Jung Soo Suk, David J Thornton, Fernando Holguin, William J Janssen, William R Thelin, Christopher M Evans
Disulfide disruption reverses mucus dysfunction in allergic airway disease. Nature communications 12 (1) (2021)
Emma K Denneny, Jagdeep Sahota, Richard Beatson, David J Thornton, Joy Burchell, Joanna Porter
Mucins and their receptors in chronic lung disease. Clinical & translational immunology 9 (3) (2020)
Kathryn A Ramsey, Alice C H Chen, Giorgia Radicioni, Rohan Lourie, Megan Martin, Amy Broomfield, Yong H Sheng, Sumaira Z Hasnain, Graham Radford-Smith, Lisa A Simms, Lucy Burr, David J Thornton, Simon D Bowler, Stephanie Livengood, Agathe Ceppe, Michael R Knowles, Peadar G Noone, Scott H Donaldson, David B Hill, Camille Ehre, Brian Button, Neil E Alexis, Mehmet Kesimer, Richard C Boucher, Michael A McGuckin
Airway Mucus Hyperconcentration in Non-Cystic Fibrosis Bronchiectasis. American journal of respiratory and critical care medicine 201 (6) (2020)
Laura Campbell, Matthew R Hepworth, Jayde Whittingham-Dowd, Seona Thompson, Allison J Bancroft, Kelly S Hayes, Tovah N Shaw, Burton F Dickey, Anne-Laure Flamar, David Artis, David A Schwartz, Christopher M Evans, Ian S Roberts, David J Thornton, Richard K Grencis
ILC2s mediate systemic innate protection by priming mucus production at distal mucosal sites. The Journal of experimental medicine 216 (12) (2019)
Gareth W Hughes, Caroline Ridley, Richard Collins, Alan Roseman, Robert Ford, David J Thornton
The MUC5B mucin polymer is dominated by repeating structural motifs and its topology is regulated by calcium and pH. Scientific reports 9 (1) (2019)
Freya R Svedberg, Sheila L Brown, Maria Z Krauss, Laura Campbell, Catherine Sharpe, Maryam Clausen, Gareth J Howell, Howard W Clark, Jens Madsen, Christopher M Evans, Tara E Sutherland, Alasdair C Ivens, David J Thornton, Richard K Grencis, Tracy Hussell, Danen M Cunoosamy, Peter Charles Cook, Andrew S MacDonald
The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation. Nature immunology 20 (5) (2019)
Maya Glover, Stefano A P Colombo, David J Thornton, Richard K Grencis
Trickle infection and immunity to Trichuris muris. PLoS pathogens 15 (11) (2019)
David J Thornton, Catherine Sharpe, Caroline Ridley
Intracellular Processing of Human Secreted Polymeric Airway Mucins. Annals of the American Thoracic Society 15 (Suppl 3) (2019)
Allison J Bancroft, Colin W Levy, Thomas A Jowitt, Kelly S Hayes, Seona Thompson, Edward A Mckenzie, Matthew D Ball, Eamon Dubaissi, Aidan P France, Bruno Bellina, Catherine Sharpe, Aleksandr Mironov, Sheila L Brown, Peter Charles Cook, Andrew S MacDonald, David J Thornton, Richard K Grencis
The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function. Nature communications 10 (1) (2019)
Caroline Ridley, Michael P Lockhart-Cairns, Richard F Collins, Thomas A Jowitt, Durai B Subramani, Mehmet Kesimer, Clair Baldock, David J Thornton
The C-terminal dimerization domain of the respiratory mucin MUC5B functions in mucin stability and intracellular packaging before secretion. The Journal of biological chemistry 294 (45) (2019)
Rebecca K Shears, Allison J Bancroft, Catherine Sharpe, Richard K Grencis, David J Thornton
Vaccination Against Whipworm: Identification of Potential Immunogenic Proteins in Trichuris muris Excretory/Secretory Material. Scientific reports 8 (1) (2018)
Caroline Ridley, David J Thornton
Mucins: the frontline defence of the lung. Biochemical Society transactions 46 (5) (2018)
C Sharpe, David J Thornton, Richard K Grencis
A sticky end for gastrointestinal helminths; the role of the mucus barrier. Parasite immunology 40 (4) (2018)
R K Shears, A J Bancroft, G W Hughes, R K Grencis, David J Thornton
Extracellular vesicles induce protective immunity against Trichuris muris. Parasite immunology 40 (7) (2018)
Eamon Dubaissi, Karine Rousseau, Gareth W Hughes, Caroline Ridley, Richard K Grencis, Ian S Roberts, David J Thornton
Functional characterization of the mucus barrier on the Xenopus tropicalis skin surface. Proceedings of the National Academy of Sciences of the United States of America 115 (4) (2018)
Felipe Melo-González, Thomas M Fenton, Cecilia Forss, Catherine Smedley, Anu Goenka, Andrew S MacDonald, David J Thornton, Mark A Travis
Intestinal mucin activates human dendritic cells and IL-8 production in a glycan-specific manner. The Journal of biological chemistry 293 (22) (2018)
Sumaira Z Hasnain, Paul A Dawson, Rohan Lourie, Peter Hutson, Hui Tong, Richard K Grencis, Michael A McGuckin, David J Thornton
Immune-driven alterations in mucin sulphation is an important mediator of Trichuris muris helminth expulsion. PLoS pathogens 13 (2) (2017)
Caroline Ridley, Sara Kirkham, Sally J Williamson, C William Davis, Philip Woodman, David J Thornton
Biosynthesis of the polymeric gel-forming mucin MUC5B. American journal of physiology. Lung cellular and molecular physiology 310 (10) (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

David J Thornton (David Thornton, D J Thornton)