Galina I Lepesheva

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 20

Top Topics

Candida Albicans

Molecular Dynamics

Top Venues

Journal of medicinal chemistry

Angewandte Chemie (International ed. in English)

The Journal of biological chemistry

ACS infectious diseases

This page only lists publications with an associated author ORCID identifier.

Publications

Kevin D McCarty, Yasuhiro Tateishi, Tatiana Y Hargrove, Galina I Lepesheva, Frederick Peter Guengerich
Oxygen-18 Labeling Reveals a Mixed Fe-O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14α-Demethylation. Angewandte Chemie (International ed. in English) (2024)
Kevin D McCarty, Yasuhiro Tateishi, Tatiana Y Hargrove, Galina I Lepesheva, Frederick Peter Guengerich
Oxygen-18 Labeling Reveals a Mixed Fe-O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14α-Demethylation. Angewandte Chemie (International ed. in English) 63 (9) (2024)
Kevin D McCarty, Yasuhiro Tateishi, Tatiana Y Hargrove, Galina I Lepesheva, Frederick Peter Guengerich
Oxygen-18 Labeling Reveals a Mixed Fe-O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14α-Demethylation. Angewandte Chemie (International ed. in English) (2024)
Kevin D McCarty, Yasuhiro Tateishi, Tatiana Y Hargrove, Galina I Lepesheva, Frederick Peter Guengerich
Oxygen-18 Labeling Reveals a Mixed Fe-O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14α-Demethylation. Angewandte Chemie (International ed. in English) 63 (9) (2024)
Tatiana Y Hargrove, David C Lamb, Zdzislaw Wawrzak, Marcus Hull, Steven L Kelly, Frederick Peter Guengerich, Galina I Lepesheva
Identification of Potent and Selective Inhibitors of Acanthamoeba : Structural Insights into Sterol 14α-Demethylase as a Key Drug Target. Journal of medicinal chemistry 67 (9) (2024)
Tatiana Y Hargrove, David C Lamb, Zdzislaw Wawrzak, Marcus Hull, Steven L Kelly, Frederick Peter Guengerich, Galina I Lepesheva
Identification of Potent and Selective Inhibitors of Acanthamoeba : Structural Insights into Sterol 14α-Demethylase as a Key Drug Target. Journal of medicinal chemistry (2024)
Sveva Pelliccia, Pasquale Russomanno, Simona Barone, Baptiste Mateu, Antonella Ilenia Alfano, Martina Miranda, Lorena Coretti, Francesca Lembo, Marialuisa Piccolo, Carlo Irace, Laura Friggeri, Tatiana Y Hargrove, Aaron Curtis, Galina I Lepesheva, Kevin Kavanagh, Elisabetta Buommino, Margherita Brindisi
A First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant Candida albicans Strain, Computational Investigation and in Vivo Validation in a Galleria mellonella Fungal Infection Model. Journal of medicinal chemistry 67 (16) (2024)
Kevin D McCarty, Yasuhiro Tateishi, Tatiana Y Hargrove, Galina I Lepesheva, Frederick Peter Guengerich
Oxygen-18 Labeling Reveals a Mixed Fe-O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14α-Demethylation. Angewandte Chemie (International ed. in English) 63 (9) (2024)
Sveva Pelliccia, Pasquale Russomanno, Simona Barone, Baptiste Mateu, Antonella Ilenia Alfano, Martina Miranda, Lorena Coretti, Francesca Lembo, Marialuisa Piccolo, Carlo Irace, Laura Friggeri, Tatiana Y Hargrove, Aaron Curtis, Galina I Lepesheva, Kevin Kavanagh, Elisabetta Buommino, Margherita Brindisi
A First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant Candida albicans Strain, Computational Investigation and in Vivo Validation in a Galleria mellonella Fungal Infection Model. Journal of medicinal chemistry 67 (16) (2024)
Tatiana Y Hargrove, David C Lamb, Zdzislaw Wawrzak, Marcus Hull, Steven L Kelly, Frederick Peter Guengerich, Galina I Lepesheva
Identification of Potent and Selective Inhibitors of Acanthamoeba : Structural Insights into Sterol 14α-Demethylase as a Key Drug Target. Journal of medicinal chemistry 67 (9) (2024)
Tatiana Y Hargrove, David C Lamb, Zdzislaw Wawrzak, Marcus Hull, Steven L Kelly, Frederick Peter Guengerich, Galina I Lepesheva
Identification of Potent and Selective Inhibitors of Acanthamoeba : Structural Insights into Sterol 14α-Demethylase as a Key Drug Target. Journal of medicinal chemistry 67 (9) (2024)
Sveva Pelliccia, Pasquale Russomanno, Simona Barone, Baptiste Mateu, Antonella Ilenia Alfano, Martina Miranda, Lorena Coretti, Francesca Lembo, Marialuisa Piccolo, Carlo Irace, Laura Friggeri, Tatiana Y Hargrove, Aaron Curtis, Galina I Lepesheva, Kevin Kavanagh, Elisabetta Buommino, Margherita Brindisi
A First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant Candida albicans Strain, Computational Investigation and in Vivo Validation in a Galleria mellonella Fungal Infection Model. Journal of medicinal chemistry (2024)
Tatiana Y Hargrove, David C Lamb, Zdzislaw Wawrzak, Marcus Hull, Steven L Kelly, Frederick Peter Guengerich, Galina I Lepesheva
Identification of Potent and Selective Inhibitors of Acanthamoeba : Structural Insights into Sterol 14α-Demethylase as a Key Drug Target. Journal of medicinal chemistry 67 (9) (2024)
Tatiana Y Hargrove, Zdzislaw Wawrzak, Girish Rachakonda, W David Nes, Fernando Villalta, Frederick Peter Guengerich, Galina I Lepesheva
Relaxed Substrate Requirements of Sterol 14α-Demethylase from Naegleria fowleri Are Accompanied by Resistance to Inhibition. Journal of medicinal chemistry 64 (23) (2021)
Tatiana Y Hargrove, Zdzislaw Wawrzak, Frederick Peter Guengerich, Galina I Lepesheva
A requirement for an active proton delivery network supports a compound I-mediated C-C bond cleavage in CYP51 catalysis. The Journal of biological chemistry 295 (29) (2020)
Maria de Nazaré Correia Soeiro, Denise da Gama Jaén Batista, Cristiane França Da Silva, Beatriz Philot Pavão, Marcos Meuser Batista, Otacílio Cruz Moreira, Letícia Rocha Quintino Souza, Constança Britto, Girish Rachakonda, Fernando Villalta, Galina I Lepesheva, Maria de Nazaré Correia Soeiro
Successful Aspects of the Coadministration of Sterol 14α-Demethylase Inhibitor VFV and Benznidazole in Experimental Mouse Models of Chagas Disease Caused by the Drug-Resistant Strain of Trypanosoma cruzi. ACS infectious diseases 5 (3) (2019)
Laura Friggeri, Tatiana Y Hargrove, Zdzislaw Wawrzak, Frederick Peter Guengerich, Galina I Lepesheva
Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors. Journal of medicinal chemistry 62 (22) (2019)
Laura Friggeri, Tatiana Y Hargrove, Girish Rachakonda, Anna L Blobaum, Paxtyn Fisher, Gabriel Melo de Oliveira, Cristiane França da Silva, Maria de Nazaré C Soeiro, W David Nes, Dennis C Liotta, Fernando Villalta, Frederick Peter Guengerich, Galina I Lepesheva
Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae. Journal of medicinal chemistry 61 (23) (2018)
Tatiana Y Hargrove, Zdzislaw Wawrzak, Paxtyn M Fisher, Stella A Child, W David Nes, Frederick Peter Guengerich, Michael R Waterman, Galina I Lepesheva
Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51. The Journal of biological chemistry 293 (50) (2018)
Laura Friggeri, Tatiana Y Hargrove, Zdzislaw Wawrzak, Anna L Blobaum, Girish Rachakonda, Dennis C Liotta, Fernando Villalta, W David Nes, Maurizio Botta, Frederick Peter Guengerich, Galina I Lepesheva
Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis. Journal of medicinal chemistry 61 (13) (2018)