Journal of medicinal chemistry

Keyphrases

Publications

volume 67, number 9, 2024

Andrew Parkins, Aliyah Veronica R Pilien, Alexander M Wolff, Christopher Argueta, Jasmine Vargas, Shahrzad Sadeghi, Andreas H Franz, Michael C Thompson, Georgios Pantouris
The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. Journal of medicinal chemistry 67 (9) (2024)
Emil Märcher Rørsted, Anders A Jensen, Gints Smits, Karla A Frydenvang, Jesper L Kristensen
Discovery and Structure-Activity Relationships of 2,5-Dimethoxyphenylpiperidines as Selective Serotonin 5-HT 2A Receptor Agonists. Journal of medicinal chemistry 67 (9) (2024)
Hong Cai, Wenchao Chen, Jing Jiang, Hao Wen, Xinyu Luo, Junjie Li, Liuxin Lu, Rui Zhao, Xinhua Ni, Yinyan Sun, Jiahui Wang, Zhen Li, Bin Ju, Xiaoying Jiang, Renren Bai
Artificial Intelligence-Assisted Optimization of Antipigmentation Tyrosinase Inhibitors: De Novo Molecular Generation Based on a Low Activity Lead Compound. Journal of medicinal chemistry 67 (9) (2024)
Jolien De Neve, Khadija Elhabazi, Simon Gonzalez, Claire Herby, Séverine Schneider, Valérie Utard, Rosine Fellmann-Clauss, Nathalie Petit-Demouliere, Sandra Lecat, Mélanie Kremer, Aurelia Ces, François Daubeuf, Charlotte Martin, Steven Ballet, Frederic Bihel, Frédéric Simonin
Multitarget μ-Opioid Receptor Agonists─Neuropeptide FF Receptor Antagonists Induce Potent Antinociception with Reduced Adverse Side Effects. Journal of medicinal chemistry 67 (9) (2024)
Ting-Ting Liu, Qing Wang, Yuxing Zhou, Baixin Ye, Tingting Liu, Linyang Yan, Jinbao Fan, Jiahao Xu, Yingjun Zhou, Zanxian Xia, Xu Deng
Discovery of a Meisoindigo-Derived PROTAC as the ATM Degrader: Revolutionizing Colorectal Cancer Therapy via Synthetic Lethality with ATR Inhibitors. Journal of medicinal chemistry 67 (9) (2024)
Yang Li, Yuyuan Zhu, Fan-Fan Shang, Lin Xu, Defang Jiang, Bin Sun, Lei Zhang, Cheng Luo, Ao Zhang, Hao Zhang, Chunyong Ding
Discovery of Urea Derivatives of Celastrol as Selective Peroxiredoxin 1 Inhibitors against Colorectal Cancer Cells. Journal of medicinal chemistry 67 (9) (2024)
Muhammet Tanc, Nicolò Filippi, Yentl Van Rymenant, Sergei Grintsevich, Isabel Pintelon, Marlies Verschuuren, Joni De Loose, Emile Verhulst, Euy Sung Moon, Lorenzo Cianni, Sigrid Stroobants, Koen Augustyns, Frank Roesch, Ingrid De Meester, Filipe Elvas, Pieter Van Der Veken
Druglike, 18 F-labeled PET Tracers Targeting Fibroblast Activation Protein. Journal of medicinal chemistry 67 (9) (2024)
Junwei Wang, Quanjin Rong, Lei Ye, Bingqian Fang, Yifan Zhao, Yu Sun, Haikun Zhou, Dan Wang, Jinting He, Zhenzhen Cui, Qijian Zhang, Di Kang, Lihong Hu
Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors. Journal of medicinal chemistry 67 (9) (2024)
Ji Eun Park, Chhabi L Chaudhary, Deepak Bhattarai, Kyung Bo Kim
Brain-Permeable Immunoproteasome-Targeting Macrocyclic Peptide Epoxyketones for Alzheimer's Disease. Journal of medicinal chemistry 67 (9) (2024)
Esra Balıkçı, Anne-Sophie M C Marques, Ludwig G Bauer, Raina Seupel, James M Bennett, Brigitt Raux, Karly Buchan, Klemensas Simelis, Usha Singh, Catherine Rogers, Jennifer Ward, Carol Cheng, Tamas Szommer, Kira Schützenhofer, Jonathan M Elkins, David L Sloman, Ivan Ahel, Oleg Fedorov, Paul E Brennan, Kilian V M Huber
Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist. Journal of medicinal chemistry 67 (9) (2024)
Yanmei He, Shimei Ruan, Guozhu Liang, Jing Hao, Xiaoyan Zhou, Zhuorui Li, Lixian Mu, Jing Wu, Hailong Yang
A Nonbactericidal Anionic Antimicrobial Peptide Provides Prophylactic and Therapeutic Efficacies against Bacterial Infections in Mice by Immunomodulatory-Antithrombotic Duality. Journal of medicinal chemistry 67 (9) (2024)
Yao Wu, Bin Li, Linkun Ying, Yao Chen, Yuxin Zhang, Chaoming Hu, Yichi Zhang, Lele Yi, Wei Wei Xue, Shengbin Huang, Zengqiang Song
Design, Synthesis, and Biological Evaluation of β-Trifluoroethoxydimethyl Selenides as Potent Antiosteoporosis Agents. Journal of medicinal chemistry 67 (9) (2024)
Lijuan Lv, Qiurong Li, Kexin Wang, Jianping Zhao, Kejun Deng, Ran Zhang, Zhong Chen, Ikhlas A Khan, Chunshan Gui, Suxiang Feng, Shilin Yang, Yanli Liu, Qiong-Ming Xu
Discovery of a New Anti-Inflammatory Agent from Anemoside B4 Derivatives and Its Therapeutic Effect on Colitis by Targeting Pyruvate Carboxylase. Journal of medicinal chemistry 67 (9) (2024)
Diego Rodríguez-Hernández, Michael K Fenwick, Rachael Zigweid, Banumathi Sankaran, Peter J Myler, Per Sunnerhagen, Alexis Kaushansky, Bart L Staker, Morten Grøtli
Exploring Subsite Selectivity within Plasmodium vivax N -Myristoyltransferase Using Pyrazole-Derived Inhibitors. Journal of medicinal chemistry 67 (9) (2024)
Min Zhao, Neng Ye, Ling Liu, Rui-Jia Zhang, Na Li, Jing Peng, Xiao-Ying Cai, Xue-Qin Jiang, Kai-Yue Su, Xin-Lu Zhang, Qian-Ru Rao, Kong-Jun Liu, De-Xin Deng, Ai-Hua Peng, Ming-Hai Tang, Li-Juan Chen, Wen-Shuang Wu, Hao-Yu Ye
Novel Isoalantolactone-Based Derivatives as Potent NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization. Journal of medicinal chemistry 67 (9) (2024)
Tesko Chaganti, Chun-Yi Tsai, Yu-Pu Juang, Mohamed Abdelalim, Tim Cernak
Medicinal Chemistry Gone Wild. Journal of medicinal chemistry 67 (9) (2024)
Qiwen Sun, Yuxiu Chu, Nana Zhang, Rui Chen, Lili Wang, Jiangxia Wu, Yongxi Dong, Hongliang Li, Ling Wang, Lei Tang, Changyou Zhan, Ji-Quan Zhang
Design, Synthesis, Formulation, and Bioevaluation of Trisubstituted Triazines as Highly Selective mTOR Inhibitors for the Treatment of Human Breast Cancer. Journal of medicinal chemistry 67 (9) (2024)
Dianne T Keough, Magdalena Petrová, Gordon King, Michal Kratochvíl, Radek Pohl, Eva Doleželová, Alena Zíková, Luke W Guddat, Dominik Rejman
Development of Prolinol Containing Inhibitors of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design. Journal of medicinal chemistry 67 (9) (2024)
Yichen Han, Adam Buric, Venkat Chintareddy, Mercedes DeMoss, Luying Chen, Jonathan Dickerhoff, Robyn De Dios, Pooran Chand, Randall Riggs, Danzhou Yang, Mark Cushman
Design, Synthesis, and Investigation of the Pharmacokinetics and Anticancer Activities of Indenoisoquinoline Derivatives That Stabilize the G-Quadruplex in the MYC Promoter and Inhibit Topoisomerase I. Journal of medicinal chemistry 67 (9) (2024)
Ekatarina Mihajlović, Lorenzo Biancalana, Sanja Jelača, Lorenzo Chiaverini, Biljana Dojčinović, Duško Dunđerović, Stefano Zacchini, Sanja Mijatović, Danijela Maksimović-Ivanić, Fabio Marchetti
FETPY: a Diiron(I) Thio-Carbyne Complex with Prominent Anticancer Activity In Vitro and In Vivo. Journal of medicinal chemistry 67 (9) (2024)
Zhe Wu, Shuqiang Chen, Zhipeng Chen, Guoqiang Dong, Defeng Xu, Chunquan Sheng
Design of Evodiamine-Glucose Conjugates with Improved In Vivo Antitumor Activity. Journal of medicinal chemistry 67 (9) (2024)
Mengyang Chang, Feng Gao, Giri Gnawali, Hang Xu, Yue Dong, Xiang Meng, Wenpan Li, Zhiren Wang, Byrdie Lopez, Jennifer S Carew, Steffan T Nawrocki, Jianqin Lu, Qing-Yu Zhang, Wei Wang
Selective Elimination of Senescent Cancer Cells by Galacto-Modified PROTACs. Journal of medicinal chemistry 67 (9) (2024)
Zixiang Li, Rufeng Ye, Qian He, Jiashuo Lu, Yanting Sun, Xiujian Sun, Siyuan Tang, Shuyang Hu, Jingrui Chai, Linghui Kong, Xiaoning Liu, Jing Chen, Yun Fang, Yingjie Lan, Qiong Xie, Jinggen Liu, Liming Shao, Wei Fu, Yujun Wang, Wei Li
Discovery of an Ortho-Substituted N -Cyclopropylmethyl-7α-phenyl-6,14- endo ethano-tetrahydronorthebaine Derivative as a Selective and Potent Kappa Opioid Receptor Agonist with Subsided Sedative Effect. Journal of medicinal chemistry 67 (9) (2024)
Rajendra Rohokale, Jiatong Guo, Zhongwu Guo
Monophosphoryl Lipid A-Rhamnose Conjugates as a New Class of Vaccine Adjuvants. Journal of medicinal chemistry 67 (9) (2024)
Xue-Qing Song, Xu Guo, Yi-Xin Ding, Yi-Xuan Han, Zhi-Hao You, Yali Song, Yanan Yuan, Long-Fei Li
Gemfibrozil-Platinum(IV) Precursors for New Enhanced-Starvation and Chemotherapy In Vitro and In Vivo. Journal of medicinal chemistry 67 (9) (2024)
Zunhua Yang, Yuqi Ying, Shaobing Cheng, Jiamin Wu, Ziwei Zhang, Pei Hu, Jian Xiong, Huilan Li, Qing Zeng, Zhifang Cai, Yulin Feng, Yuanying Fang
Discovery of Selective Proteolysis-Targeting Chimera Degraders Targeting PTP1B as Long-Term Hypoglycemic Agents. Journal of medicinal chemistry 67 (9) (2024)
Lufeng Zheng, Yuxin Zhang, Shuang Mei, Tianyuan Xie, Yunting Zou, Yuting Wang, Han Jing, Shengtao Xu, Pierre Dramou, Zhen Xu, Jindong Li, Yang Zhou, Miao-Miao Niu
Discovery of a Potent Dual Son of Sevenless 1 (SOS1) and Epidermal Growth Factor Receptor (EGFR) Inhibitor for the Treatment of Prostate Cancer. Journal of medicinal chemistry 67 (9) (2024)
Jiapeng Li, Daniel Macedo de Melo Jorge, Weiwen Wang, Shuxin Sun, Tristan Frum, Yu-An Hang, Yueting Liu, Xingwu Zhou, Jingcheng Xiao, Xinwen Wang, Jason R Spence, Christiane E Wobus, Hao-Jie Zhu
Differential Bioactivation Profiles of Different GS-441524 Prodrugs in Cell and Mouse Models: ProTide Prodrugs with High Cell Permeability and Susceptibility to Cathepsin A Are More Efficient in Delivering Antiviral Active Metabolites to the Lung. Journal of medicinal chemistry 67 (9) (2024)
Lianchao Liu, Abhijit Parolia, Yihan Liu, Caiyun Hou, Tongchen He, Yuanyuan Qiao, Sanjana Eyunni, Jie Luo, Chungen Li, Yongxing Wang, Fengtao Zhou, Weixue Huang, Xiaomei Ren, Zhen Wang, Arul M Chinnaiyan, Ke Ding
Discovery of LLC0424 as a Potent and Selective in Vivo NSD2 PROTAC Degrader. Journal of medicinal chemistry 67 (9) (2024)
Rajendra Rohokale, Jiatong Guo, Zhongwu Guo
Monophosphoryl Lipid A-Rhamnose Conjugates as a New Class of Vaccine Adjuvants. Journal of medicinal chemistry 67 (9) (2024)
Tatiana Y Hargrove, David C Lamb, Zdzislaw Wawrzak, Marcus Hull, Steven L Kelly, Frederick Peter Guengerich, Galina I Lepesheva
Identification of Potent and Selective Inhibitors of Acanthamoeba : Structural Insights into Sterol 14α-Demethylase as a Key Drug Target. Journal of medicinal chemistry 67 (9) (2024)
Kewon Kim, Ahyoung Jang, Hochul Shin, Inhae Ye, Ji Eun Lee, Taeho Kim, Hwangseo Park, Sungwoo Hong
Concurrent Optimizations of Efficacy and Blood-Brain Barrier Permeability in New Macrocyclic LRRK2 Inhibitors for Potential Parkinson's Disease Therapeutics. Journal of medicinal chemistry 67 (9) (2024)
Yasheng Zhu, Xiuquan Ye, Yuxing Wu, Hao Shen, Zeyu Cai, Fei Xia, Wenjian Min, Yi Hou, Liping Wang, Xiao Wang, Yibei Xiao, Peng Yang
Design, Synthesis, and Biological Evaluation of Novel EGFR PROTACs Targeting C797S Mutation. Journal of medicinal chemistry 67 (9) (2024)
Rajendra Rohokale, Jiatong Guo, Zhongwu Guo
Monophosphoryl Lipid A-Rhamnose Conjugates as a New Class of Vaccine Adjuvants. Journal of medicinal chemistry 67 (9) (2024)
Binbin Cheng, Xiaoting Fei, Zongbao Ding, Xiaopeng Peng, Zhenhong Su, Wei Pan, Jianjun Chen
Recent Progress in DNA Damage Response-Targeting PROTAC Degraders. Journal of medicinal chemistry 67 (9) (2024)
Xuemei Dong, Hongyu Wu, Ziwen Zhang, Jie Sun, Chengjun Dong, Lixin Sun, Rongchen Wang, Xianfeng Gu, Chunchang Zhao
Depletion and Downregulation of Hydrogen Sulfide Using an Activatable Probe for Promoting Photothermal Therapy toward Colorectal Cancers. Journal of medicinal chemistry 67 (9) (2024)
Jia-Ling Zou, Kai-Xiang Chen, Xiao-Juan Wang, Zheng-Chang Lu, Xian-Hui Wu, Yun-Dong Wu
Structure-Based Rational and General Strategy for Stabilizing Single-Chain T-Cell Receptors to Enhance Affinity. Journal of medicinal chemistry 67 (9) (2024)
Terry W Moore, William C K Pomerantz
Celebrating the 60th Anniversary of the MIKIW Meeting-in-Miniature: Virtual Special Issue. Journal of medicinal chemistry 67 (9) (2024)
Patricia Grabher, Paul Kapitza, Nikolas Hörmann, Amelie Scherfler, Martin Hermann, Michael Zwerger, Hristo P Varbanov, Brigitte Kircher, Daniel Baecker, Ronald Gust
Correction to "Development of Cytotoxic GW7604-Zeise's Salt Conjugates as Multitarget Compounds with Selectivity for Estrogen Receptor-Positive Tumor Cells". Journal of medicinal chemistry 67 (9) (2024)
Stuart Lang, Martin J Slater
Virtual Screening Strategies for Identifying Novel Chemotypes. Journal of medicinal chemistry 67 (9) (2024)
Jiankang Hu, Hongrui Xu, Tianbang Wu, Cheng Zhang, Hui Shen, Ruibo Dong, Qingqing Hu, Qiuping Xiang, Shuang Chai, Guolong Luo, Xiaoshan Chen, Yumin Huang, Xiaofan Zhao, Chao Peng, Xishan Wu, Bin Lin, Yan Zhang, Yong Xu
Discovery of Highly Potent and Efficient CBP/p300 Degraders with Strong In Vivo Antitumor Activity. Journal of medicinal chemistry 67 (9) (2024)
Rajendra Rohokale, Jiatong Guo, Zhongwu Guo
Monophosphoryl Lipid A-Rhamnose Conjugates as a New Class of Vaccine Adjuvants. Journal of medicinal chemistry 67 (9) (2024)
Chun-Lan Xie, Hong-Xiu Xiao, Pei-Fang Song, Qing-Mei Liu, Haoxiang Wei, Liang Wu, Guang-Hao Zhu, Guang-Ming Liu, Yandong Zhang, Ping Wang, Xian-Wen Yang
Lead Optimization of Butyrolactone I as an Orally Bioavailable Antiallergic Agent Targeting FcγRIIB. Journal of medicinal chemistry 67 (9) (2024)
Salma M Hefny, Tarek F El-Moselhy, Nabaweya El-Din, Simone Giovannuzzi, Thamer Bin Traiki, Mansoor-Ali Vaali-Mohammed, Ahmed M El-Dessouki, Koki Yamaguchi, Masaharu Sugiura, Moataz A Shaldam, Claudiu T Supuran, Maha-Hamadien Abdulla, Wagdy M Eldehna, Haytham O Tawfik
Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro , In Vivo , and In Silico Investigations of Coumarin-Based Thiazoles. Journal of medicinal chemistry 67 (9) (2024)
Xue-Qing Song, Xu Guo, Yi-Xin Ding, Yi-Xuan Han, Zhi-Hao You, Yali Song, Yanan Yuan, Long-Fei Li
Gemfibrozil-Platinum(IV) Precursors for New Enhanced-Starvation and Chemotherapy In Vitro and In Vivo. Journal of medicinal chemistry 67 (9) (2024)
Sven Falke, Julia Lieske, Alexander Herrmann, Jure Loboda, Katarina Karničar, Sebastian Günther, Patrick Y A Reinke, Wiebke Ewert, Aleksandra Usenik, Nataša Lindič, Andreja Sekirnik, Klemen Dretnik, Hideaki Tsuge, Vito Turk, Henry N Chapman, Winfried Hinrichs, Gregor Ebert, Dušan Turk, Alke Meents
Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors. Journal of medicinal chemistry 67 (9) (2024)
Hunter T Warren, Hannah N Saeger, Robert J Tombari, Milan Chytil, Kurt Rasmussen, David E Olson
Psychoplastogenic DYRK1A Inhibitors with Therapeutic Effects Relevant to Alzheimer's Disease. Journal of medicinal chemistry 67 (9) (2024)
Bing-Bing Xu, Nan Jin, Ji-Cheng Liu, Ai-Qiu Liao, Hong-Yu Lin, Xiu-Ying Qin
Arene-Arene Coupled Disulfamethazines (or Sulfadiazine)-Phenanthroline-Metal(II) Complexes were Synthesized by In Situ Reactions and Inhibited the Growth and Development of Triple-Negative Breast Cancer through the Synergistic Effect of Antiangiogenesis, Anti-Inflammation, Pro-Apoptosis, and Cuproptosis. Journal of medicinal chemistry 67 (9) (2024)
Sven Falke, Julia Lieske, Alexander Herrmann, Jure Loboda, Katarina Karničar, Sebastian Günther, Patrick Y A Reinke, Wiebke Ewert, Aleksandra Usenik, Nataša Lindič, Andreja Sekirnik, Klemen Dretnik, Hideaki Tsuge, Vito Turk, Henry N Chapman, Winfried Hinrichs, Gregor Ebert, Dušan Turk, Alke Meents
Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors. Journal of medicinal chemistry 67 (9) (2024)
Chaitra Chandrashekar, Feng Lin, Yuji Nishiuchi, Sam F Mohammed, Barbara F White, Yanni Arsenakis, Elita Yuliantie, Peishen Zhao, Sam van Dun, Anna Koijen, Yasuhiro Kajihara, Denise Wootten, Garron T Dodd, Leendert J van den Bos, John D Wade, Mohammed Akhter Hossain
Engineering of a Biologically Active Glycosylated Glucagon-Like Peptide-1 Analogue. Journal of medicinal chemistry 67 (9) (2024)