Kyriacos C Nicolaou (K C Nicolaou)

Publication Activity (10 Years)

Years Active: 2017-2022
Publications (10 Years): 27

Top Topics

Anti Inflammatory

Molecular Docking

Acinetobacter Baumannii

Top Venues

Journal of the American Chemical Society

The Journal of organic chemistry

Proceedings of the National Academy of Sciences of the United States of America

Accounts of chemical research

This page only lists publications with an associated author ORCID identifier.

Publications

Kyriacos C Nicolaou, Ruocheng Yu, Zhaoyong Lu, Fernando G Alvarez
Total Synthesis of Gukulenin B via Sequential Tropolone Functionalizations. Journal of the American Chemical Society 144 (11) (2022)
Kyriacos C Nicolaou, Saiyong Pan, Yogesh Shelke, Stephan Rigol, Ruiyang Bao, Dipendu Das, Qiuji Ye
A unified strategy for the total syntheses of eribulin and a macrolactam analogue of halichondrin B. Proceedings of the National Academy of Sciences of the United States of America 119 (32) (2022)
Kyriacos C Nicolaou, Saiyong Pan, Kiran K Pulukuri, Qiuji Ye, Stephan Rigol, Rohan D Erande, Dionisios Vourloumis, Bogusław P Nocek, Stefan Munneke, Joseph Lyssikatos, Amanda Valdiosera, Christine Gu, Baiwei Lin, Hetal Sarvaiaya, Jose Trinidad, Joseph Sandoval, Christina Lee, Mikhail Hammond, Monette Aujay, Nicole Taylor, Marybeth Pysz, James W Purcell, Julia Gavrilyuk
Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody-Drug Conjugates, Insights into Structure-Activity Relationships, and Tubulysin-Tubulin Binding Derived from X-ray Crystallographic Analysis. The Journal of organic chemistry 86 (4) (2021)
Kyriacos C Nicolaou, Saiyong Pan, Yogesh Shelke, Qiuji Ye, Dipendu Das, Stephan Rigol
A Highly Convergent Total Synthesis of Norhalichondrin B. Journal of the American Chemical Society (2021)
Kyriacos C Nicolaou, Saiyong Pan, Yogesh G Shelke, Dipendu Das, Qiuji Ye, Yong Lu, Susanta Sau, Ruiyang Bao, Stephan Rigol
A Reverse Approach to the Total Synthesis of Halichondrin B. Journal of the American Chemical Society 143 (24) (2021)
Kyriacos C Nicolaou, Santhosh Reddy Rekula, S Mothish Kumar, Ananda Rao Podilapu, Ryan P Matuszak, Paul M Jung, Lloyd T Lam, Andrew C Phillips, Joseph Lyssikatos, Stefan Munneke, Christine Gu, Hetal Sarvaiya, Joseph Sandoval, Mikhail Hammond, Monette Aujay, James W Purcell, Regina M Reilly, Julia Gavrilyuk
Design, Synthesis, and Biological Investigation of Thailanstatin A and Spliceostatin D Analogues Containing Tetrahydropyran, Tetrahydrooxazine, and Fluorinated Structural Motifs. The Journal of organic chemistry 86 (3) (2021)
Kyriacos C Nicolaou, Stephan Rigol, Emmanuel N Pitsinos, Dipendu Das, Yong Lu, Subhrajit Rout, Alexander W Schammel, Dane Holte, Baiwei Lin, Christine Gu, Hetal Sarvaiya, Jose Trinidad, Nicole Barbour, Amanda M Valdiosera, Joseph Sandoval, Christina Lee, Monette Aujay, Hanan Fernando, Anukriti Dhar, Holger Karsunky, Nicole Taylor, Marybeth Pysz, Julia Gavrilyuk
Uncialamycin-based antibody-drug conjugates: Unique enediyne ADCs exhibiting bystander killing effect. Proceedings of the National Academy of Sciences of the United States of America 118 (25) (2021)
Kyriacos C Nicolaou, Qifeng Chen, Ruofan Li, Yasuaki Anami, Kyoji Tsuchikama
Total Synthesis of the Monomeric Unit of Lomaiviticin A. Journal of the American Chemical Society 142 (47) (2020)
Kyriacos C Nicolaou, Dipendu Das, Yong Lu, Subhrajit Rout, Emmanuel N Pitsinos, Joseph Lyssikatos, Alexander Schammel, Joseph Sandoval, Mikhail Hammond, Monette Aujay, Julia Gavrilyuk
Total Synthesis and Biological Evaluation of Tiancimycins A and B, Yangpumicin A, and Related Anthraquinone-Fused Enediyne Antitumor Antibiotics. Journal of the American Chemical Society 142 (5) (2020)
Kyriacos C Nicolaou, Johannes Krieger, Ganesh M Murhade, Parthasarathi Subramanian, Balu D Dherange, Dionisios Vourloumis, Stefan Munneke, Baiwei Lin, Christine Gu, Hetal Sarvaiaya, Joseph Sandoval, Zhaomei Zhang, Monette Aujay, James W Purcell, Julia Gavrilyuk
Streamlined Symmetrical Total Synthesis of Disorazole B1 and Design, Synthesis, and Biological Investigation of Disorazole Analogues. Journal of the American Chemical Society 142 (36) (2020)
Kyriacos C Nicolaou, Yogesh G Shelke, Balu D Dherange, Aaron Kempema, Baiwei Lin, Christine Gu, Joseph Sandoval, Mikhail Hammond, Monette Aujay, Julia Gavrilyuk
Design, Synthesis, and Biological Investigation of Epothilone B Analogues Featuring Lactone, Lactam, and Carbocyclic Macrocycles, Epoxide, Aziridine, and 1,1-Difluorocyclopropane and Other Fluorine Residues. The Journal of organic chemistry 85 (5) (2020)
Kyriacos C Nicolaou, Stephan Rigol
The Role of Organic Synthesis in the Emergence and Development of Antibody-Drug Conjugates as Targeted Cancer Therapies. Angewandte Chemie (International ed. in English) 58 (33) (2019)
Hao Zhang, Ruofan Li, Sai Ba, Zhaoyong Lu, Emmanuel N Pitsinos, Tianhu Li, Kyriacos C Nicolaou
DNA Binding and Cleavage Modes of Shishijimicin A. Journal of the American Chemical Society 141 (19) (2019)
Kyriacos C Nicolaou, Kiran Kumar Pulukuri, Stephan Rigol, Zisis Peitsinis, Ruocheng Yu, Satoshi Kishigami, Nicholas Cen, Monette Aujay, Joseph Sandoval, Nancy Zepeda, Julia Gavrilyuk
Correction to "Short Total Synthesis of Δ12-Prostaglandin J2 and Related Prostaglandins. Design, Synthesis, and Biological Evaluation of Macrocyclic Δ12-Prostaglandin J2 Analogues". The Journal of organic chemistry 84 (4) (2019)
Kyriacos C Nicolaou, Rohan D Erande, Jun Yin, Dionisios Vourloumis, Monette Aujay, Joseph Sandoval, Stefan Munneke, Julia Gavrilyuk
Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody-Drug Conjugates. Journal of the American Chemical Society 140 (10) (2018)
Kyriacos C Nicolaou, Marek Buchman, Gabriel Bellavance, Johannes Krieger, Parthasarathi Subramanian, Kiran Kumar Pulukuri
Syntheses of Cyclopropyl Analogues of Disorazoles A1 and B1 and Their Thiazole Counterparts. The Journal of organic chemistry 83 (20) (2018)
Kyriacos C Nicolaou, Ruofan Li, Zhaoyong Lu, Emmanuel N Pitsinos, Lawrence B Alemany
Total Synthesis and Full Structural Assignment of Namenamicin. Journal of the American Chemical Society 140 (26) (2018)
Kyriacos C Nicolaou, Kiran Kumar Pulukuri, Stephan Rigol, Zisis Peitsinis, Ruocheng Yu, Satoshi Kishigami, Nicholas Cen, Monette Aujay, Joseph Sandoval, Nancy Zepeda, Julia Gavrilyuk
Short Total Synthesis of Δ12-Prostaglandin J2 and Related Prostaglandins. Design, Synthesis, and Biological Evaluation of Macrocyclic Δ12-Prostaglandin J2 Analogues. The Journal of organic chemistry 84 (1) (2018)
Kyriacos C Nicolaou, Derek Rhoades, S Mothish Kumar
Total Syntheses of Thailanstatins A-C, Spliceostatin D, and Analogues Thereof. Stereodivergent Synthesis of Tetrasubstituted Dihydro- and Tetrahydropyrans and Design, Synthesis, Biological Evaluation, and Discovery of Potent Antitumor Agents. Journal of the American Chemical Society 140 (26) (2018)
Kyriacos C Nicolaou, Ruofan Li, Zhaoyong Lu, Emmanuel N Pitsinos, Lawrence B Alemany, Monette Aujay, Christina Lee, Joseph Sandoval, Julia Gavrilyuk
Streamlined Total Synthesis of Shishijimicin A and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues thereof and Practical Syntheses of PhthNSSMe and Related Sulfenylating Reagents. Journal of the American Chemical Society 140 (38) (2018)
Kyriacos C Nicolaou, Stephan Rigol
Total Synthesis in Search of Potent Antibody-Drug Conjugate Payloads. From the Fundamentals to the Translational. Accounts of chemical research 52 (1) (2018)
Kyriacos C Nicolaou, Kiran Kumar Pulukuri, Stephan Rigol, Marek Buchman, Akshay A Shah, Nicholas Cen, Megan D McCurry, Kathryn Beabout, Yousif Shamoo
Enantioselective Total Synthesis of Antibiotic CJ-16,264, Synthesis and Biological Evaluation of Designed Analogues, and Discovery of Highly Potent and Simpler Antibacterial Agents. Journal of the American Chemical Society 139 (44) (2017)
Kyriacos C Nicolaou, Gabriel Bellavance, Marek Buchman, Kiran Kumar Pulukuri
Total Syntheses of Disorazoles A₁ and B₁ and Full Structural Elucidation of Disorazole B₁. Journal of the American Chemical Society 139 (44) (2017)
Kathryn Beabout, Megan D McCurry, Heer Mehta, Akshay A Shah, Kiran Kumar Pulukuri, Stephan Rigol, Yanping Wang, Kyriacos C Nicolaou, Yousif Shamoo
Experimental Evolution of Diverse Strains as a Method for the Determination of Biochemical Mechanisms of Action for Novel Pyrrolizidinone Antibiotics. ACS infectious diseases 3 (11) (2017)
Kyriacos C Nicolaou, Guodu Liu, Kathryn Beabout, Megan D McCurry, Yousif Shamoo
Asymmetric Alkylation of Anthrones, Enantioselective Total Synthesis of (-)- and (+)-Viridicatumtoxins B and Analogues Thereof: Absolute Configuration and Potent Antibacterial Agents. Journal of the American Chemical Society 139 (10) (2017)
Kyriacos C Nicolaou, Pengxi Chen, Shugao Zhu, Quan Cai, Rohan D Erande, Ruofan Li, Hongbao Sun, Kiran Kumar Pulukuri, Stephan Rigol, Monette Aujay, Joseph Sandoval, Julia Gavrilyuk
Streamlined Total Synthesis of Trioxacarcins and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues Thereof. Discovery of Simpler Designed and Potent Trioxacarcin Analogues. Journal of the American Chemical Society 139 (43) (2017)
Kyriacos C Nicolaou, Derek Rhoades, Yanping Wang, Ruoli Bai, Ernest Hamel, Monette Aujay, Joseph Sandoval, Julia Gavrilyuk
12,13-Aziridinyl Epothilones. Stereoselective Synthesis of Trisubstituted Olefinic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design, Synthesis, and Biological Evaluation of Potent Antitumor Agents. Journal of the American Chemical Society 139 (21) (2017)