Luke S Alphey (Luke Alphey)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 30

Top Venues

Nature communications

BMC biology

Proceedings of the National Academy of Sciences of the United States of America

PLoS neglected tropical diseases

The Pirbright Institute

University of Dundee (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

The Pirbright Institute

United Kingdom

Group Leader :: Vector-borne Viral Diseases

University of Oxford

United Kingdom

Visiting Professor of Genetics :: Zoology

Oxitec Ltd Feb 01 2014 - Sep 04 2015

United Kingdom

Non-executive director

Oxitec Ltd

United Kingdom

Co-founder and Chief Scientist

University of Oxford

United Kingdom

Reader in Genetics :: Zoology

University of Oxford

United Kingdom

MRC Senior Research Fellow :: Zoology

University of Manchester

United Kingdom

Lecturer :: Biological Sciences

University of Dundee

United Kingdom

Post-doc (supervisor: Prof David Glover) :: Biochemistry

Imperial College London

United Kingdom

Post-doc (supervisor: Prof David Glover) :: Biochemistry

Education History

University of Dundee

United Kingdom

PHD :: Biochemistry

Publications

Philip Thomas Leftwich, Jessica C Purcell, Michelle A E Anderson, Rennos Fragkoudis, Sanjay Basu, Gareth J Lycett, Luke S Alphey
A Synthetic Biology Approach to Transgene Expression in Insects. ACS synthetic biology (2024)
Cameron J McNamara, Thomas H Ant, Tim Harvey-Samuel, Helen White-Cooper, Julien Martinez, Luke S Alphey, Steven P Sinkins
Transgenic expression of cif genes from Wolbachia strain wAlbB recapitulates cytoplasmic incompatibility in Aedes aegypti. Nature communications 15 (1) (2024)
Michelle A E Anderson, Estela González, Matthew P Edgington, Joshua X D Ang, Deepak-Kumar Purusothaman, Lewis Shackleford, Katherine Nevard, Sebald A N Verkuijl, Timothy Harvey-Samuel, Philip Thomas Leftwich, Kevin Esvelt, Luke S Alphey
A multiplexed, confinable CRISPR/Cas9 gene drive can propagate in caged Aedes aegypti populations. Nature communications 15 (1) (2024)
Cameron J McNamara, Thomas H Ant, Tim Harvey-Samuel, Helen White-Cooper, Julien Martinez, Luke S Alphey, Steven P Sinkins
Transgenic expression of cif genes from Wolbachia strain wAlbB recapitulates cytoplasmic incompatibility in Aedes aegypti. Nature communications 15 (1) (2024)
Michelle A E Anderson, Estela González, Matthew P Edgington, Joshua X D Ang, Deepak-Kumar Purusothaman, Lewis Shackleford, Katherine Nevard, Sebald A N Verkuijl, Timothy Harvey-Samuel, Philip Thomas Leftwich, Kevin Esvelt, Luke S Alphey
A multiplexed, confinable CRISPR/Cas9 gene drive can propagate in caged Aedes aegypti populations. Nature communications 15 (1) (2024)
Michelle A E Anderson, Estela González, Matthew P Edgington, Joshua X D Ang, Deepak-Kumar Purusothaman, Lewis Shackleford, Katherine Nevard, Sebald A N Verkuijl, Timothy Harvey-Samuel, Philip Thomas Leftwich, Kevin Esvelt, Luke S Alphey
A multiplexed, confinable CRISPR/Cas9 gene drive can propagate in caged Aedes aegypti populations. Nature communications 15 (1) (2024)
Cameron J McNamara, Thomas H Ant, Tim Harvey-Samuel, Helen White-Cooper, Julien Martinez, Luke S Alphey, Steven P Sinkins
Transgenic expression of cif genes from Wolbachia strain wAlbB recapitulates cytoplasmic incompatibility in Aedes aegypti. Nature communications 15 (1) (2024)
Cameron J McNamara, Thomas H Ant, Tim Harvey-Samuel, Helen White-Cooper, Julien Martinez, Luke S Alphey, Steven P Sinkins
Transgenic expression of cif genes from Wolbachia strain wAlbB recapitulates cytoplasmic incompatibility in Aedes aegypti. Nature communications 15 (1) (2024)
Cameron J McNamara, Thomas H Ant, Tim Harvey-Samuel, Helen White-Cooper, Julien Martinez, Luke S Alphey, Steven P Sinkins
Transgenic expression of cif genes from Wolbachia strain wAlbB recapitulates cytoplasmic incompatibility in Aedes aegypti. Nature communications 15 (1) (2024)
Michelle A E Anderson, Estela González, Matthew P Edgington, Joshua X D Ang, Deepak-Kumar Purusothaman, Lewis Shackleford, Katherine Nevard, Sebald A N Verkuijl, Timothy Harvey-Samuel, Philip Thomas Leftwich, Kevin Esvelt, Luke S Alphey
A multiplexed, confinable CRISPR/Cas9 gene drive can propagate in caged Aedes aegypti populations. Nature communications 15 (1) (2024)
Tim Harvey-Samuel, Xuechun Feng, Emily M Okamoto, Deepak-Kumar Purusothaman, Philip Thomas Leftwich, Luke S Alphey, Valentino Matteo Gantz
CRISPR-based gene drives generate super-Mendelian inheritance in the disease vector Culex quinquefasciatus. Nature communications 14 (1) (2023)
Luke S Alphey
Sex or poison? Genetic pest management in the 21st century. BMC biology 21 (1) (2023)
Christine M Reitmayer, Emily Levitt, Sanjay Basu, Barry Atkinson, Rennos Fragkoudis, Andres Merits, Sarah Lumley, Will Larner, Adriana V Díaz, Sara Rooney, Callum J E Thomas, Katharina von Wyschetzki, Kai Rausalu, Luke S Alphey
Mimicking superinfection exclusion disrupts alphavirus infection and transmission in the yellow fever mosquito Aedes aegypti . Proceedings of the National Academy of Sciences of the United States of America 120 (37) (2023)
Luke S Alphey
Sex or poison? Genetic pest management in the 21st century. BMC biology 21 (1) (2023)
Luke S Alphey
Sex or poison? Genetic pest management in the 21st century. BMC biology 21 (1) (2023)
Tim Harvey-Samuel, Xuechun Feng, Emily M Okamoto, Deepak-Kumar Purusothaman, Philip Thomas Leftwich, Luke S Alphey, Valentino Matteo Gantz
CRISPR-based gene drives generate super-Mendelian inheritance in the disease vector Culex quinquefasciatus . bioRxiv : the preprint server for biology (2023)
Luke S Alphey
Sex or poison? Genetic pest management in the 21st century. BMC biology 21 (1) (2023)
Luke S Alphey
Sex or poison? Genetic pest management in the 21st century. BMC biology 21 (1) (2023)
Luke S Alphey
Sex or poison? Genetic pest management in the 21st century. BMC biology 21 (1) (2023)
Tim Harvey-Samuel, Xuejiao Xu, Michelle A E Anderson, Leonela Z Carabajal Paladino, Deepak-Kumar Purusothaman, Victoria C Norman, Christine M Reitmayer, Minsheng You, Luke S Alphey
Silencing RNAs expressed from W-linked <i>PxyMasc</i> "retrocopies" target that gene during female sex determination in <i>Plutella xylostella</i>. Proceedings of the National Academy of Sciences of the United States of America 119 (46) (2022)
Liubov Cherkashchenko, Kai Rausalu, Sanjay Basu, Luke S Alphey, Andres Merits
Expression of Alphavirus Nonstructural Protein 2 (nsP2) in Mosquito Cells Inhibits Viral RNA Replication in Both a Protease Activity-Dependent and -Independent Manner. Viruses 14 (6) (2022)
Priscilla Y L Tng, Leonela Z Carabajal Paladino, Michelle A E Anderson, Zach N Adelman, Rennos Fragkoudis, Rob Noad, Luke S Alphey
Intron-derived small RNAs for silencing viral RNAs in mosquito cells. PLoS neglected tropical diseases 16 (6) (2022)
Joshua Xin De Ang, Katherine Nevard, Rebekah Ireland, Deepak-Kumar Purusothaman, Sebald A N Verkuijl, Lewis Shackleford, Estela González, Michelle A E Anderson, Luke S Alphey
Considerations for homology-based DNA repair in mosquitoes: Impact of sequence heterology and donor template source. PLoS genetics 18 (2) (2022)
Deepak-Kumar Purusothaman, Lewis Shackleford, Michelle A E Anderson, Tim Harvey-Samuel, Luke S Alphey
CRISPR/Cas-9 mediated knock-in by homology dependent repair in the West Nile Virus vector Culex quinquefasciatus Say. Scientific reports 11 (1) (2021)
Luke S Alphey, Andrea Crisanti, Filippo Fil Randazzo, Omar S Akbari
Opinion: Standardizing the definition of gene drive. Proceedings of the National Academy of Sciences of the United States of America 117 (49) (2020)
Priscilla Ying Lei Tng, Leonela Carabajal Paladino, Sebald Alexander Nkosana Verkuijl, Jessica Purcell, Andres Merits, Philip Thomas Leftwich, Rennos Fragkoudis, Rob Noad, Luke S Alphey
Cas13b-dependent and Cas13b-independent RNA knockdown of viral sequences in mosquito cells following guide RNA expression. Communications biology 3 (1) (2020)
Laura Sandra Lello, Age Utt, Koen Bartholomeeusen, Sainan Wang, Kai Rausalu, Catherine Kendall, Sandra Coppens, Rennos Fragkoudis, Andrew Tuplin, Luke S Alphey, Kevin K Ariën, Andres Merits
Cross-utilisation of template RNAs by alphavirus replicases. PLoS pathogens 16 (9) (2020)
Roya Elaine Haghighat-Khah, Tim Harvey-Samuel, Sanjay Basu, Sebald A N Verkuijl, Sarah Scaife, Sebald Verkuijl, Erica Lovett, Luke S Alphey
Engineered action at a distance: Blood-meal-inducible paralysis in Aedes aegypti. PLoS neglected tropical diseases 13 (9) (2019)
Michelle A E Anderson, Jessica Mavica, Lewis Shackleford, Ilona Flis, Sophia Fochler, Sanjay Basu, Luke S Alphey
CRISPR/Cas9 gene editing in the West Nile Virus vector, Culex quinquefasciatus Say. PloS one 14 (11) (2019)
Luke S Alphey
Can CRISPR-Cas9 gene drives curb malaria? Nature biotechnology 34 (2) (2016)

Luke S Alphey.css-eqlu8i{font-size:small;padding-left:4px;} (Luke Alphey)

Publication Activity (10 Years)

Top Topics

Top Venues

Luke S Alphey (Luke Alphey)