Michael D Aleo

Publication Activity (10 Years)

Years Active: 2017-2023
Publications (10 Years): 11

Top Topics

Estrogen Receptor

Acinetobacter Baumannii

Top Venues

Chemical research in toxicology

Journal of applied toxicology : JAT

Pharmacology research & perspectives

This page only lists publications with an associated author ORCID identifier.

Publications

Mohan Rao, Vahid Nassiri, Cristóbal Alhambra, Jan Snoeys, Freddy Van Goethem, Onyi Irrechukwu, Michael D Aleo, Helena Geys, Kaushik Mitra, Yvonne Will
AI/ML Models to Predict the Severity of Drug-Induced Liver Injury for Small Molecules. Chemical research in toxicology (2023)
Payal Rana, Stephen Kogut, Xuerong Wen, Fatemeh Akhlaghi, Michael D Aleo
Most Influential Physicochemical and In Vitro Assay Descriptors for Hepatotoxicity and Nephrotoxicity Prediction. Chemical research in toxicology 33 (7) (2020)
Michael D Aleo, Colleen M Doshna, Daniel Baltrukonis, Jay H Fortner, Cynthia A Drupa, Kimberly A Navetta, Carol A Fritz, David M Potter, Maria E Verdugo, William P Beierschmitt
Lens cholesterol biosynthesis inhibition: A common mechanism of cataract formation in laboratory animals by pharmaceutical products. Journal of applied toxicology : JAT 39 (9) (2019)
Grant Generaux, Vinal V Lakhani, Yuching Yang, Sashi Nadanaciva, Luping Qiu, Keith Riccardi, Li Di, Brett A Howell, Scott Q Siler, Paul B Watkins, Hugh A Barton, Michael D Aleo, Lisl K M Shoda
Quantitative systems toxicology (QST) reproduces species differences in PF-04895162 liver safety due to combined mitochondrial and bile acid toxicity. Pharmacology research & perspectives 7 (6) (2019)
Laura Goracci, Aurora Valeri, Simone Sciabola, Michael D Aleo, Wolfgang Moritz, Jan Lichtenberg, Gabriele Cruciani
A Novel Lipidomics-Based Approach to Evaluating the Risk of Clinical Hepatotoxicity Potential of Drugs in 3D Human Microtissues. Chemical research in toxicology 33 (1) (2019)
Michael D Aleo, Jiri Aubrecht, Paul D Bonin, Deborah A Burt, Jennifer Colangelo, Lina Luo, Shelli Schomaker, Rachel Swiss, Simon Kirby, Greg C Rigdon, Pinky Dua
Phase I study of PF‐04895162, a Kv7 channel opener, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis. Pharmacology research & perspectives 7 (1) (2019)
Michael D Aleo, Falgun Shah, Scott Allen, Hugh A Barton, Chester Costales, Sarah Lazzaro, Louis Leung, Andrea Nilson, R Scott Obach, A David Rodrigues, Yvonne Will
Moving beyond Binary Predictions of Human Drug-Induced Liver Injury (DILI) toward Contrasting Relative Risk Potential. Chemical research in toxicology 33 (1) (2019)
Michael D Aleo, Okechukwu Ukairo, Amanda Moore, Onyi Irrechukwu, David M Potter, Richard P Schneider
Liver safety evaluation of endothelin receptor antagonists using HepatoPac® : A single model impact assessment on hepatocellular health, function and bile acid disposition. Journal of applied toxicology : JAT 39 (8) (2019)
Payal Rana, Michael D Aleo, Mark Gosink, Yvonne Will
Evaluation of in Vitro Mitochondrial Toxicity Assays and Physicochemical Properties for Prediction of Organ Toxicity Using 228 Pharmaceutical Drugs. Chemical research in toxicology 32 (1) (2018)
Michael D Aleo, Falgun Shah, Kan He, Paul D Bonin, A David Rodrigues
Correction to Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals. Chemical research in toxicology 30 (6) (2017)
Michael D Aleo, Falgun Shah, Kan He, Paul D Bonin, A David Rodrigues
Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals. Chemical research in toxicology 30 (5) (2017)