Nick E Le Brun

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 32

Top Venues

Angewandte Chemie (International ed. in English)

Chemical science

Microbiology spectrum

Journal of the American Chemical Society

University of East Anglia

University of East Anglia (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of East Anglia Aug 01 2011

United Kingdom

Professor of Biological Chemistry :: School of Chemistry

University of East Anglia Aug 01 2009 - Jul 31 2011

United Kingdom

Reader in Biological Chemistry :: School of Chemistry

University of East Anglia Aug 01 2006 - Jul 31 2009

United Kingdom

Senior Lecturer in Biological Chemistry :: School of Chemistry

University of East Anglia Oct 01 1999 - Jul 31 2006

United Kingdom

Lecturer in Biological Chemistry :: School of Chemistry

University of East Anglia Sep 01 1998 - Sep 30 1999

United Kingdom

PDRA :: School of Chemical Sciences

Lunds Universitet Aug 01 1996 - Jul 31 1998

Sweden

EMBO Long Term Fellowship :: Department of Microbiology

University of East Anglia Nov 01 1995 - Jul 31 1996

United Kingdom

PDRA :: School of Chemical Sciences

University of East Anglia Nov 01 1993 - Oct 31 1995

United Kingdom

Wellcome Trust Prize Fellowship :: School of Chemical Sciences

Education History

University of East Anglia Oct 01 1990 - Jul 16 1994

United Kingdom

PHD :: School of Chemical Sciences

University of East Anglia Oct 05 1987 - Jul 15 1990

United Kingdom

BSC :: School of Chemical Sciences

Publications

Paolo Olivieri, Moritz Klabes, Jason C Crack, Angelika Lehmann, Sophie P Bennett, Nick E Le Brun, Silke Leimkühler
Binding of IscU and TusA to different but competing sites of IscS influences the activity of IscS and directs sulfur to the respective biomolecular synthesis pathway. Microbiology spectrum (2024)
Paolo Olivieri, Moritz Klabes, Jason C Crack, Angelika Lehmann, Sophie P Bennett, Nick E Le Brun, Silke Leimkühler
Binding of IscU and TusA to different but competing sites of IscS influences the activity of IscS and directs sulfur to the respective biomolecular synthesis pathway. Microbiology spectrum (2024)
Justin M Bradley, Zinnia Bugg, Aaren Sackey, Simon C Andrews, Michael T Wilson, Dimitri A Svistunenko, Geoffrey R Moore, Nick E Le Brun
The Ferroxidase Centre of Escherichia coli Bacterioferritin Plays a Key Role in the Reductive Mobilisation of the Mineral Iron Core. Angewandte Chemie (International ed. in English) 63 (16) (2024)
Paolo Olivieri, Moritz Klabes, Jason C Crack, Angelika Lehmann, Sophie P Bennett, Nick E Le Brun, Silke Leimkühler
Binding of IscU and TusA to different but competing sites of IscS influences the activity of IscS and directs sulfur to the respective biomolecular synthesis pathway. Microbiology spectrum (2024)
Justin M Bradley, Zinnia Bugg, Aaren Sackey, Simon C Andrews, Michael T Wilson, Dimitri A Svistunenko, Geoffrey R Moore, Nick E Le Brun
The Ferroxidase Centre of Escherichia coli Bacterioferritin Plays a Key Role in the Reductive Mobilisation of the Mineral Iron Core. Angewandte Chemie (International ed. in English) 63 (16) (2024)
Justin M Bradley, Zinnia Bugg, Aaren Sackey, Simon C Andrews, Michael T Wilson, Dimitri A Svistunenko, Geoffrey R Moore, Nick E Le Brun
The Ferroxidase Centre of Escherichia coli Bacterioferritin Plays a Key Role in the Reductive Mobilisation of the Mineral Iron Core. Angewandte Chemie (International ed. in English) 63 (16) (2024)
Justin M Bradley, Zinnia Bugg, Aaren Sackey, Simon C Andrews, Michael T Wilson, Dimitri A Svistunenko, Geoffrey R Moore, Nick E Le Brun
The Ferroxidase Centre of Escherichia coli Bacterioferritin Plays a Key Role in the Reductive Mobilisation of the Mineral Iron Core. Angewandte Chemie (International ed. in English) (2024)
Elizabeth Gray, Melissa Y Y Stewart, Libby Hanwell, Jason C Crack, Rebecca Devine, Clare E M Stevenson, Anne Volbeda, Andrew W B Johnston, Juan C Fontecilla-Camps, Matthew I Hutchings, Jonathan D Todd, Nick E Le Brun
Stabilisation of the RirA [4Fe-4S] cluster results in loss of iron-sensing function. Chemical science 14 (36) (2023)
Ming Peng, Chun-Yang Li, Xiu-Lan Chen, Beth T Williams, Kang Li, Ya-Nan Gao, Peng Wang, Ning Wang, Chao Gao, Shan Zhang, Marie C Schoelmerich, Jillian F Banfield, J Benjamin Miller, Nick E Le Brun, Jonathan D Todd, Yu-Zhong Zhang
Insights into methionine S-methylation in diverse organisms. Nature communications 13 (1) (2022)
Jason C Crack, Basema K Balasiny, Sophie P Bennett, Matthew D Rolfe, Afonso Froes, Fraser MacMillan, Jeffrey Green, Jeffrey A Cole, Nick E Le Brun
The Di-Iron Protein YtfE Is a Nitric Oxide-Generating Nitrite Reductase Involved in the Management of Nitrosative Stress. Journal of the American Chemical Society 144 (16) (2022)
Chieh-Chih George Yeh, Thirakorn Mokkawes, Justin M Bradley, Nick E Le Brun, Sam P De Visser
Second Coordination Sphere Effects on the Mechanistic Pathways for Dioxygen Activation by a Ferritin: Involvement of a Tyr Radical and the Identification of a Cation Binding Site. Chembiochem : a European journal of chemical biology 23 (13) (2022)
Sophie P Bennett, Jason C Crack, Rita Puglisi, Annalisa Pastore, Nick E Le Brun
Native mass spectrometric studies of IscSU reveal a concerted, sulfur-initiated mechanism of iron-sulfur cluster assembly. Chemical science 14 (1) (2022)
Roman Rohac, Jason C Crack, Eve de Rosny, Océane Gigarel, Nick E Le Brun, Juan C Fontecilla-Camps, Anne Volbeda
Structural determinants of DNA recognition by the NO sensor NsrR and related Rrf2-type [FeS]-transcription factors. Communications biology 5 (1) (2022)
Justin M Bradley, Elizabeth Gray, Jake Richardson, Geoffrey R Moore, Nick E Le Brun
Protein encapsulation within the internal cavity of a bacterioferritin. Nanoscale 14 (34) (2022)
Jacob Pullin, Michael T Wilson, Martin Clémancey, Geneviève Blondin, Justin M Bradley, Geoffrey R Moore, Nick E Le Brun, Marina Lučić, Jonathan A R Worrall, Dimitri A Svistunenko
Iron Oxidation in Escherichia coli Bacterioferritin Ferroxidase Centre, a Site Designed to React Rapidly with H 2 O 2 but Slowly with O 2 . Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 133 (15) (2021)
Jacob Pullin, Michael T Wilson, Martin Clémancey, Geneviève Blondin, Justin M Bradley, Geoffrey R Moore, Nick E Le Brun, Marina Lučić, Jonathan A R Worrall, Dimitri A Svistunenko
Iron Oxidation in Escherichia coli Bacterioferritin Ferroxidase Centre, a Site Designed to React Rapidly with H2 O2 but Slowly with O2. Angewandte Chemie (International ed. in English) 60 (15) (2021)
Jacob Pullin, Michael T Wilson, Martin Clémancey, Geneviève Blondin, Justin M Bradley, Geoffrey R Moore, Nick E Le Brun, Marina Lučić, Jonathan A R Worrall, Dimitri A Svistunenko
Iron Oxidation in Escherichia coli Bacterioferritin Ferroxidase Centre, a Site Designed to React Rapidly with H 2 O 2 but Slowly with O 2 . Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 133 (15) (2021)
Melissa Y Y Stewart, Matthew J Bush, Jason C Crack, Mark J Buttner, Nick E Le Brun
Interaction of the Streptomyces Wbl protein WhiD with the principal sigma factor σHrdB depends on the WhiD [4Fe-4S] cluster. The Journal of biological chemistry 295 (28) (2020)
Jason C Crack, Patricia Amara, Anne Volbeda, Jean-Marie Mouesca, Roman Rohac, Ma Teresa Pellicer Martinez, Chia Yiang Huang, Océane Gigarel, Clara Rinaldi, Nick E Le Brun, Juan C Fontecilla-Camps
Electron and Proton Transfers Modulate DNA Binding by the Transcription Regulator RsrR. Journal of the American Chemical Society 142 (11) (2020)
Justin M Bradley, Dimitri A Svistunenko, Michael T Wilson, Andrew M Hemmings, Geoffrey R Moore, Nick E Le Brun
Bacterial iron detoxification at the molecular level. The Journal of biological chemistry (2020)
Sophie P Bennett, Manuel J Soriano-Laguna, Justin M Bradley, Dimitri A Svistunenko, David J Richardson, Andrew J Gates, Nick E Le Brun
NosL is a dedicated copper chaperone for assembly of the CuZ center of nitrous oxide reductase. Chemical science 10 (19) (2019)
Ma Teresa Pellicer Martinez, Jason C Crack, Melissa Yy Stewart, Justin M Bradley, Dimitri A Svistunenko, Andrew Wb Johnston, Myles R Cheesman, Jonathan D Todd, Nick E Le Brun
Mechanisms of iron- and O2-sensing by the [4Fe-4S] cluster of the global iron regulator RirA. eLife 8 (2019)
Justin M Bradley, Dimitri A Svistunenko, Jacob Pullin, Natalie Hill, Rhona K Stuart, Brian Palenik, Michael T Wilson, Andrew M Hemmings, Geoffrey R Moore, Nick E Le Brun
Reaction of O2 with a diiron protein generates a mixed-valent Fe2+/Fe3+ center and peroxide. Proceedings of the National Academy of Sciences of the United States of America 116 (6) (2019)
Anne Volbeda, Ma Teresa Pellicer Martinez, Jason C Crack, Patricia Amara, Océane Gigarel, John T Munnoch, Matthew I Hutchings, Claudine Darnault, Nick E Le Brun, Juan C Fontecilla-Camps
Crystal Structure of the Transcription Regulator RsrR Reveals a [2Fe-2S] Cluster Coordinated by Cys, Glu, and His Residues. Journal of the American Chemical Society 141 (6) (2019)
Jason C Crack, Nick E Le Brun
Mass Spectrometric Identification of [4Fe-4S](NO)x Intermediates of Nitric Oxide Sensing by Regulatory Iron-Sulfur Cluster Proteins. Chemistry (Weinheim an der Bergstrasse, Germany) 25 (14) (2019)
Jason C Crack, Melissa Y Y Stewart, Nick E Le Brun
Generation of 34S-substituted protein-bound [4Fe-4S] clusters using 34S-L-cysteine. Biology methods & protocols 4 (1) (2019)
Stella A Child, Justin M Bradley, Tara Louise Pukala, Dimitri A Svistunenko, Nick E Le Brun, Stephen G Bell
Electron transfer ferredoxins with unusual cluster binding motifs support secondary metabolism in many bacteria. Chemical science 9 (41) (2018)
Justin M Bradley, Dimitri A Svistunenko, Geoffrey R Moore, Nick E Le Brun
Tyr25, Tyr58 and Trp133 of Escherichia coli bacterioferritin transfer electrons between iron in the central cavity and the ferroxidase centre. Metallomics : integrated biometal science 9 (10) (2018)
Kristine L Kay, Liang Zhou, Leonardo Tenori, Justin M Bradley, Chloe Singleton, Margaret A Kihlken, Simone Ciofi-Baffoni, Nick E Le Brun
Kinetic analysis of copper transfer from a chaperone to its target protein mediated by complex formation. Chemical communications (Cambridge, England) 53 (8) (2018)
Bassam K Kudhair, Andrea M Hounslow, Matthew D Rolfe, Jason C Crack, Debbie M Hunt, Roger S Buxton, Laura J Smith, Nick E Le Brun, Michael P Williamson, Jeffrey Green
Structure of a Wbl protein and implications for NO sensing by M. tuberculosis. Nature communications 8 (1) (2017)
Jason C Crack, Andrew J Thomson, Nick E Le Brun
Mass spectrometric identification of intermediates in the O2-driven [4Fe-4S] to [2Fe-2S] cluster conversion in FNR. Proceedings of the National Academy of Sciences of the United States of America 114 (16) (2017)
Ma Teresa Pellicer Martinez, Ana Bermejo Martinez, Jason C Crack, John D Holmes, Dimitri A Svistunenko, Andrew W B Johnston, Myles R Cheesman, Jonathan D Todd, Nick E Le Brun
Sensing iron availability via the fragile [4Fe-4S] cluster of the bacterial transcriptional repressor RirA. Chemical science 8 (12) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Nick E Le Brun