Richard J Spears

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 10

Top Topics

Top Venues

Chemical science

Chemical communications (Cambridge, England)

Acta crystallographica. Section D, Structural biology

This page only lists publications with an associated author ORCID identifier.

Publications

Afzaal Tufail, Saeed Akkad, Natasha E Hatton, Nicholas D J Yates, Richard J Spears, Tessa Keenan, Alison Parkin, Nathalie Signoret, Martin A Fascione
Cross aldol OPAL bioconjugation outcompetes intramolecular hemiaminal cyclisation of proline adjacent N-terminal α-oxo aldehydes at acidic pH. RSC advances 14 (6) (2024)
Steven Y Yap, Tobias Butcher, Richard J Spears, Clíona McMahon, Ioanna A Thanasi, James Richard Baker, Vijay Chudasama
Chemo- and regio-selective differential modification of native cysteines on an antibody via the use of dehydroalanine forming reagents. Chemical science 15 (22) (2024)
Steven Y Yap, Tobias Butcher, Richard J Spears, Clíona McMahon, Ioanna A Thanasi, James Richard Baker, Vijay Chudasama
Chemo- and regio-selective differential modification of native cysteines on an antibody via the use of dehydroalanine forming reagents. Chemical science 15 (22) (2024)
Afzaal Tufail, Saeed Akkad, Natasha E Hatton, Nicholas D J Yates, Richard J Spears, Tessa Keenan, Alison Parkin, Nathalie Signoret, Martin A Fascione
Cross aldol OPAL bioconjugation outcompetes intramolecular hemiaminal cyclisation of proline adjacent N-terminal α-oxo aldehydes at acidic pH. RSC advances 14 (6) (2024)
Léa N C Rochet, Calise Bahou, Jonathan P Wojciechowski, Ilias Koutsopetras, Phyllida Britton, Richard J Spears, Ioanna A Thanasi, Baihao Shao, Lisha Zhong, Dejan-Krešimir Bučar, Abil E Aliev, Michael J Porter, Molly M Stevens, James Richard Baker, Vijay Chudasama
Use of pyridazinediones for tuneable and reversible covalent cysteine modification applied to peptides, proteins and hydrogels. Chemical science 14 (47) (2023)
Richard J Spears, Alina Chrzastek, Steven Y Yap, Kersti Karu, Abil E Aliev, James Richard Baker, Vijay Chudasama
Unearthing the unique stability of thiophosphonium-C-terminal cysteine adducts on peptides and proteins. Chemical communications (Cambridge, England) 58 (35) (2022)
Nehaal Ahmed, Richard J Spears, Tom D Sheppard, Vijay Chudasama
Functionalisation of ethereal-based saturated heterocycles with concomitant aerobic C-H activation and C-C bond formation. Chemical science 13 (29) (2022)
Richard J Spears, Clíona McMahon, Monika Shamsabadi, Calise Bahou, Ioanna A Thanasi, Léa N C Rochet, Nafsika Forte, Fabien Thoreau, James Richard Baker, Vijay Chudasama
A novel thiol-labile cysteine protecting group for peptide synthesis based on a pyridazinedione (PD) scaffold. Chemical communications (Cambridge, England) (2021)
Richard J Spears, Robin L Brabham, Darshita Budhadev, Tessa Keenan, Sophie McKenna, Julia Walton, James A Brannigan, Andrzej Marek Brzozowski, Anthony J Wilkinson, Michael J Plevin, Martin A Fascione
Site-selective C-C modification of proteins at neutral pH using organocatalyst-mediated cross aldol ligations. Chemical science 9 (25) (2018)
Andrew J Thompson, Richard J Spears, Yanping Zhu, Michael D L Suits, Spencer J Williams, Harry J Gilbert, Gideon J Davies
Bacteroides thetaiotaomicron generates diverse α-mannosidase activities through subtle evolution of a distal substrate-binding motif. Acta crystallographica. Section D, Structural biology 74 (Pt 5) (2018)