Roberto Jorge Botelho (Roberto J Botelho)

Scopus Author ID ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 17

Top Venues

The Journal of cell biology

Nature cell biology

PloS one

Microbiology spectrum

Ryerson University

University of Toronto (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Ryerson University Aug 01 2008

Canada

Associate Professor :: Chemistry and Biology

Education History

University of Toronto Sep 01 1998 - Nov 15 2004

Canada

PHD :: Biochemistry

Publications

Victoria Chan, Cristina Camardi, Kai Zhang, Laura A Orofiamma, Karen E Anderson, Jafarul Hoque, Leslie N Bone, Yasmin Awadeh, Daniel K C Lee, Norman J Fu, Jonathan T S Chow, Leonardo Salmena, Len R Stephens, Phillip T Hawkins, Costin N Antonescu, Roberto Jorge Botelho
The LCLAT1/LYCAT acyltransferase is required for EGF-mediated phosphatidylinositol-3,4,5-trisphosphate generation and Akt signaling. Molecular biology of the cell 35 (9) (2024)
Ruiqi Cai, Ori Scott, Gang Ye, Trieu Le, Ekambir Saran, Whijin Kwon, Subothan Inpanathan, Blayne Amir Sayed, Roberto Jorge Botelho, Amra Saric, Stefan Uderhardt, Spencer A Freeman
Pressure sensing of lysosomes enables control of TFEB responses in macrophages. Nature cell biology 26 (8) (2024)
Golam T Saffi, Lydia To, Nicholas Kleine, Ché M P Melo, Keyue Chen, Gizem Genc, K C Daniel Lee, Jonathan Tak-Sum Chow, Gun Ho Jang, Steven J Gallinger, Roberto Jorge Botelho, Leonardo Salmena
INPP4B promotes PDAC aggressiveness via PIKfyve and TRPML-1-mediated lysosomal exocytosis. The Journal of cell biology 223 (11) (2024)
Ruiqi Cai, Ori Scott, Gang Ye, Trieu Le, Ekambir Saran, Whijin Kwon, Subothan Inpanathan, Blayne Amir Sayed, Roberto Jorge Botelho, Amra Saric, Stefan Uderhardt, Spencer A Freeman
Pressure sensing of lysosomes enables control of TFEB responses in macrophages. Nature cell biology (2024)
Golam T Saffi, Lydia To, Nicholas Kleine, Ché M P Melo, Keyue Chen, Gizem Genc, K C Daniel Lee, Jonathan Tak-Sum Chow, Gun Ho Jang, Steven J Gallinger, Roberto Jorge Botelho, Leonardo Salmena
INPP4B promotes PDAC aggressiveness via PIKfyve and TRPML-1-mediated lysosomal exocytosis. The Journal of cell biology 223 (11) (2024)
Subothan Inpanathan, Erika Ospina-Escobar, Vanessa Cruz Li, Zainab Adamji, Tracy Lackraj, Youn Hee Cho, Natasha Porco, Christopher H Choy, Joseph B McPhee, Roberto Jorge Botelho
Salmonella actively modulates TFEB in murine macrophages in a growth-phase and time-dependent manner. Microbiology spectrum (2023)
Maxime Boutry, Laura F DiGiovanni, Nicholas Demers, Aaron Fountain, Sami Mamand, Roberto Jorge Botelho, Peter Kijun Kim
Arf1-PI4KIIIβ positive vesicles regulate PI(3)P signaling to facilitate lysosomal tubule fission. The Journal of cell biology 222 (9) (2023)
Rebecca Cabral-Dias, Stefanie Lucarelli, Karolina Zak, Sadia Rahmani, Gurjeet Judge, John Abousawan, Laura F DiGiovanni, Dafne Vural, Karen E Anderson, Michael G Sugiyama, Gizem Genc, Wanjin Hong, Roberto Jorge Botelho, Gregory D Fairn, Peter Kijun Kim, Costin N Antonescu
Fyn and TOM1L1 are recruited to clathrin-coated pits and regulate Akt signaling. The Journal of cell biology 221 (4) (2022)
Golam T Saffi, Evan Tang, Sami Mamand, Subothan Inpanathan, Aaron Fountain, Leonardo Salmena, Roberto Jorge Botelho
Reactive oxygen species prevent lysosome coalescence during PIKfyve inhibition. PloS one 16 (11) (2021)
Charlene E Lancaster, Aaron Fountain, Roaya M Dayam, Elliott Somerville, Javal Sheth, Vanessa Jacobelli, Alex Somerville, Mauricio R Terebiznik, Roberto Jorge Botelho
Phagosome resolution regenerates lysosomes and maintains the degradative capacity in phagocytes. The Journal of cell biology 220 (9) (2021)
Victoria E B Hipolito, Jacqueline A Diaz, Kristofferson V Tandoc, Christian Oertlin, Johannes Ristau, Neha Chauhan, Amra Saric, Shannon Mclaughlan, Ola Larsson, Ivan Topisirovic, Roberto Jorge Botelho
Enhanced translation expands the endo-lysosome size and promotes antigen presentation during phagocyte activation. PLoS biology 17 (12) (2019)
James Won Suk Jahng, Reham Musaibeh Alsaadi, Rengasamy Palanivel, Erfei Song, Victoria Emily Barbosa Hipolito, Hye Kyoung Sung, Roberto Jorge Botelho, Ryan Charles Russell, Gary Sweeney
Iron overload inhibits late stage autophagic flux leading to insulin resistance. EMBO reports 20 (10) (2019)
Christopher H Choy, Golam Saffi, Matthew A Gray, Callen Wallace, Roya M Dayam, Zhen-Yi A Ou, Guy Lenk, Rosa Puertollano, Simon C Watkins, Roberto Jorge Botelho
Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence. Journal of cell science 131 (10) (2018)
Krishna Chintaluri, Brady D Goulden, Camilyn Clemenza, Golam Saffi, Emily Miraglia, Gerald R V Hammond, Roberto Jorge Botelho
The PH domain from the Toxoplasma gondii PH-containing protein-1 (TgPH1) serves as an ectopic reporter of phosphatidylinositol 3-phosphate in mammalian cells. PloS one 13 (6) (2018)
Victoria E B Hipolito, Erika Ospina-Escobar, Roberto Jorge Botelho
Lysosome remodelling and adaptation during phagocyte activation. Cellular microbiology 20 (4) (2018)
Roya M Dayam, Chun X Sun, Christopher H Choy, Gemma Mancuso, Michael Glogauer, Roberto Jorge Botelho
The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase. Journal of immunology (Baltimore, Md. : 1950) 199 (6) (2017)
Amriya Naufer, Victoria E B Hipolito, Suriakarthiga Ganesan, Akriti Prashar, Vanina Zaremberg, Roberto Jorge Botelho, Mauricio R Terebiznik
pH of endophagosomes controls association of their membranes with Vps34 and PtdIns(3)P levels. The Journal of cell biology 217 (1) (2017)

Roberto Jorge Botelho.css-eqlu8i{font-size:small;padding-left:4px;} (Roberto J Botelho)

Publication Activity (10 Years)

Top Topics

Top Venues

Roberto Jorge Botelho (Roberto J Botelho)