Sophie E Legge (Sophie Legge, S E Legge)

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 22

Top Topics

Embryonic Stem Cells

Spectrum Disorder

Genome Wide Association Study

Top Venues

Translational psychiatry

The British journal of psychiatry : the journal of mental science

medRxiv : the preprint server for health sciences

Molecular psychiatry

This page only lists publications with an associated author ORCID identifier.

Publications

Xavier Caseras, Emily Simmonds, Antonio F Pardinas, Richard J L Anney, Sophie E Legge, James T R Walters, Neil A Harrison, Michael C O'Donovan, Valentina Escott-Price
Common risk alleles for schizophrenia within the major histocompatibility complex predict white matter microstructure. Translational psychiatry 14 (1) (2024)
Edward Silva, Sophie E Legge, Cecilia Casetta, Eromona Whiskey, Ebenezer Oloyede, Siobhan Gee
Understanding clozapine-related blood dyscrasias. Developments, genetics, ethnicity and disparity: it's a CIN. BJPsych bulletin (2024)
Xavier Caseras, Emily Simmonds, Antonio F Pardinas, Richard J L Anney, Sophie E Legge, James T R Walters, Neil A Harrison, Michael C O'Donovan, Valentina Escott-Price
Common risk alleles for schizophrenia within the major histocompatibility complex predict white matter microstructure. Translational psychiatry 14 (1) (2024)
Xavier Caseras, Emily Simmonds, Antonio F Pardinas, Richard J L Anney, Sophie E Legge, James T R Walters, Neil A Harrison, Michael C O'Donovan, Valentina Escott-Price
Common risk alleles for schizophrenia within the major histocompatibility complex predict white matter microstructure. Translational psychiatry 14 (1) (2024)
Xavier Caseras, Emily Simmonds, Antonio F Pardinas, Richard J L Anney, Sophie E Legge, James T R Walters, Neil A Harrison, Michael C O'Donovan, Valentina Escott-Price
Common risk alleles for schizophrenia within the major histocompatibility complex predict white matter microstructure. Translational psychiatry 14 (1) (2024)
Xavier Caseras, Emily Simmonds, Antonio F Pardinas, Richard J L Anney, Sophie E Legge, James T R Walters, Neil A Harrison, Michael C O'Donovan, Valentina Escott-Price
Common risk alleles for schizophrenia within the major histocompatibility complex predict white matter microstructure. Translational psychiatry 14 (1) (2024)
Grace E Woolway, Sophie E Legge, Amy Lynham, Sophie E Smart, Leon Hubbard, Ellie R Daniel, Antonio F Pardiñas, Valentina Escott-Price, Michael C O'Donovan, Michael J Owen, Ian R Jones, James Tr Walters
Assessing the validity of a self-reported clinical diagnosis of schizophrenia. medRxiv : the preprint server for health sciences (2023)
Michael J Owen, Sophie E Legge, Elliott Rees, James T R Walters, Michael C O'Donovan
Genomic findings in schizophrenia and their implications. Molecular psychiatry (2023)
Grace E Woolway, Sophie E Legge, Amy Lynham, Sophie E Smart, Leon Hubbard, Ellie R Daniel, Antonio F Pardiñas, Valentina Escott-Price, Michael C O'Donovan, Michael J Owen, Ian R Jones, James Tr Walters
Assessing the validity of a self-reported clinical diagnosis of schizophrenia. medRxiv : the preprint server for health sciences (2023)
Grace E Woolway, Sophie E Legge, Amy Lynham, Sophie E Smart, Leon Hubbard, Ellie R Daniel, Antonio F Pardiñas, Valentina Escott-Price, Michael C O'Donovan, Michael J Owen, Ian R Jones, James Tr Walters
Assessing the validity of a self-reported clinical diagnosis of schizophrenia. medRxiv : the preprint server for health sciences (2023)
Bret Sanders, Daniel D'Andrea, Mark O Collins, Elliott Rees, Tom G J Steward, Ying Zhu, Gareth Chapman, Sophie E Legge, Antonio F Pardinas, Adrian J Harwood, William Peter Gray, Michael C O'Donovan, Michael J Owen, Adam C Errington, Derek J Blake, Daniel J Whitcomb, Andrew J Pocklington, Eunju Shin
Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants. Nature communications 13 (1) (2022)
Tom Chambers, Valentina Escott-Price, Sophie E Legge, Emily Baker, Krish D Singh, James T R Walters, Xavier Caseras, Richard J L Anney
Genetic common variants associated with cerebellar volume and their overlap with mental disorders: a study on 33,265 individuals from the UK-Biobank. Molecular psychiatry 27 (4) (2022)
Cynthia Okhuijsen-Pfeifer, Marte van der Horst, Chad A Bousman, B Lin, K R van Eijk, S Ripke, Y Ayhan, M O Babaoglu, M Bak, W Alink, H van Beek, E Beld, A Bouhuis, M Edlinger, I M Erdogan, A Ertuğrul, G Yoca, I P Everall, T Görlitz, null null, K P Grootens, S Gutwinski, T Hallikainen, E Jeger-Land, M de Koning, Markku Lähteenvuo, Sophie E Legge, S Leucht, C Morgenroth, A Müderrisoğlu, A Narang, Christos Pantelis, Antonio F Pardinas, T Oviedo-Salcedo, J Schneider-Thoma, S Schreiter, E Repo-Tiihonen, H Tuppurainen, M Veereschild, S Veerman, M de Vos, Elias Wagner, D Cohen, Jan P A M Bogers, J T R Walters, A E Anil Yağcıoğlu, Jari Tiihonen, A Hasan, Jurjen J Luykx
Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorders. Translational psychiatry 12 (1) (2022)
Cecilia Casetta, Ebenezer Oloyede, Eromona Whiskey, David Michael Taylor, Fiona Gaughran, Sukhi S Shergill, Juliana Onwumere, Aviv Segev, Olubanke Dzahini, Sophie E Legge, James Hunter MacCabe
A retrospective study of intramuscular clozapine prescription for treatment initiation and maintenance in treatment-resistant psychosis. The British journal of psychiatry : the journal of mental science 217 (3) (2021)
Sophie E Legge, Charlotte A Dennison, Antonio F Pardiñas, Elliott Rees, Amy J Lynham, Lucinda Hopkins, Lesley Bates, George Kirov, Michael J Owen, Michael C O'Donovan, James T R Walters
Clinical indicators of treatment-resistant psychosis. The British journal of psychiatry : the journal of mental science 216 (5) (2021)
Bettina Konte, James T R Walters, Dan Rujescu, Sophie E Legge, Antonio F Pardinas, Dan Cohen, Munir Pirmohamed, Jari Tiihonen, Annette M Hartmann, Jan P A M Bogers, Jan van der Weide, Karen van der Weide, Anu Putkonen, Eila Repo-Tiihonen, Tero Hallikainen, Edward Silva, Oddur Ingimarsson, Engilbert Sigurdsson, Ayeshah G Mohiuddin, Patrick F Sullivan, Marcella D C Rietschel, Gerome Breen, Hreinn Stefánsson, Kari Stefansson, David A Collier, Michael C O'Donovan, Ina Giegling
HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry. Translational psychiatry 11 (1) (2021)
Sophie E Legge, Marcos Leite Santoro, Sathish Periyasamy, Adeniran Okewole, Arsalan Arsalan, Kaarina Kowalec
Genetic architecture of schizophrenia: a review of major advancements. Psychological medicine 51 (13) (2021)
Xavier Caseras, George Kirov, Kimberley M Kendall, Elliott Rees, Sophie E Legge, Matthew Bracher-Smith, Valentina Escott-Price, Kevin Murphy
Effects of genomic copy number variants penetrant for schizophrenia on cortical thickness and surface area in healthy individuals: analysis of the UK Biobank. The British journal of psychiatry : the journal of mental science 218 (2) (2021)
Kimberley M Kendall, Ann John, Sze Chim Lee, Elliott Rees, Antonio F Pardiñas, Marcos Del Pozo Banos, Michael J Owen, Michael C O'Donovan, George Kirov, Keith Lloyd, Ian Jones, Sophie E Legge, James T R Walters
Impact of schizophrenia genetic liability on the association between schizophrenia and physical illness: data-linkage study. BJPsych open 6 (6) (2020)
Steluta Grama, Isabella Willcocks, John J Hubert, Antonio F Pardinas, Sophie E Legge, Matthew Bracher-Smith, Georgina E Menzies, Lynsey S Hall, Andrew J Pocklington, Richard J L Anney, Nicholas J Bray, Valentina Escott-Price, Xavier Caseras
Polygenic risk for schizophrenia and subcortical brain anatomy in the UK Biobank cohort. Translational psychiatry 10 (1) (2020)
Sophie E Legge, Antonio F Pardinas, Marinka Helthuis, John A Jansen, Karel Jollie, Steven Knapper, James Hunter MacCabe, Dan Rujescu, David A Collier, Michael C O'Donovan, Michael J Owen, James T R Walters
A genome-wide association study in individuals of African ancestry reveals the importance of the Duffy-null genotype in the assessment of clozapine-related neutropenia. Molecular psychiatry 24 (3) (2019)
Antonio F Pardinas, Peter Holmans, Andrew J Pocklington, Valentina Escott-Price, Stephan Ripke, Noa Carrera, Sophie E Legge, Sophie Bishop, Darren Cameron, Marian L Hamshere, Jun Han, Leon Hubbard, Amy Joanne Lynham, Kiran Mantripragada, Elliott Rees, James Hunter MacCabe, Steven A McCarroll, Bernhard T Baune, Gerome D Breen, Enda M Byrne, Udo Dannlowski, Thalia C Eley, Caroline Hayward, Nicholas G Martin, Andrew M McIntosh, Robert Plomin, David J Porteous, Naomi R Wray, Armando Caballero, Daniel H Geschwind, Laura M Huckins, Douglas M Ruderfer, Enrique Santiago, Pamela Sklar, Eli A Stahl, Hyejung Won, Esben Agerbo, Thomas Damm Als, Ole A Andreassen, Marie Bækvad-Hansen, Preben Bo Mortensen, Carsten Bøcker Pedersen, Anders D Børglum, Jonas Byberg-Grauholm, Srdjan Djurovic, Naser Durmishi, Marianne Giørtz Pedersen, Vera Golimbet, Jakob Grove, David Michael Hougaard, Manuel Mattheisen, Espen Molden, Ole Mors, Merete Nordentoft, Milica Pejovic-Milovancevic, Engilbert Sigurdsson, Teimuraz Silagadze, Christine Søholm Hansen, Kari Stefansson, Hreinn Stefansson, Stacy Steinberg, Sarah Tosato, Thomas Werge, null null, null null, David A Collier, Dan Rujescu, George Kirov, Michael J Owen, Michael C O'Donovan, James T R Walters
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nature genetics 50 (3) (2018)