Sulayman D Dib-Hajj (Sulayman Dib-Hajj, Fadia B Dib-Hajj)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 51

Top Topics

Neuropathic Pain

Spinal Cord Injury

Transcranial Direct Current Stimulation

Atopic Dermatitis

Top Venues

Journal of neurophysiology

Communications biology

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Ana Paula Nascimento de Lima, Huiran Zhang, Lubin Chen, Philip R Effraim, Carolina Gomis-Perez, Xiaoyang Cheng, Jianying Huang, Stephen G Waxman, Sulayman D Dib-Hajj
Nav1.8 in small dorsal root ganglion neurons contributes to vincristine-induced mechanical allodynia. Brain : a journal of neurology 147 (9) (2024)
Mohammad-Reza Ghovanloo, Philip R Effraim, Sidharth Tyagi, Peng Zhao, Sulayman D Dib-Hajj, Stephen G Waxman
Functionally-selective inhibition of threshold sodium currents and excitability in dorsal root ganglion neurons by cannabinol. Communications biology 7 (1) (2024)
Mohammad-Reza Ghovanloo, Philip R Effraim, Sidharth Tyagi, Peng Zhao, Sulayman D Dib-Hajj, Stephen G Waxman
Functionally-selective inhibition of threshold sodium currents and excitability in dorsal root ganglion neurons by cannabinol. Communications biology 7 (1) (2024)
Sulayman D Dib-Hajj, Stephen G Waxman
Species-specific differences and the role of Nav1.9 in pain pathophysiology. Pain (2024)
Mohammad-Reza Ghovanloo, Sulayman D Dib-Hajj, Stephen G Waxman
The evolution of patch-clamp electrophysiology: robotic, multiplex, and dynamic. Molecular pharmacology (2024)
Sidharth Tyagi, Grant P Higerd-Rusli, Elizabeth J Akin, Christopher A Baker, Shujun Liu, Fadia B Dib-Hajj, Stephen G Waxman, Sulayman D Dib-Hajj
Real-time imaging of axonal membrane protein life cycles. Nature protocols (2024)
Mohammad-Reza Ghovanloo, Philip R Effraim, Sidharth Tyagi, Peng Zhao, Sulayman D Dib-Hajj, Stephen G Waxman
Functionally-selective inhibition of threshold sodium currents and excitability in dorsal root ganglion neurons by cannabinol. Communications biology 7 (1) (2024)
Roberta Gualdani, Solène Barbeau, Jun-Hui Yuan, Deborah S Jacobs, Philippe Gailly, Sulayman D Dib-Hajj, Stephen G Waxman
TRPV1 corneal neuralgia mutation: Enhanced pH response, bradykinin sensitization, and capsaicin desensitization. Proceedings of the National Academy of Sciences of the United States of America 121 (37) (2024)
Mohammad-Reza Ghovanloo, Philip R Effraim, Sidharth Tyagi, Peng Zhao, Sulayman D Dib-Hajj, Stephen G Waxman
Functionally-selective inhibition of threshold sodium currents and excitability in dorsal root ganglion neurons by cannabinol. Communications biology 7 (1) (2024)
Sidharth Tyagi, Grant P Higerd-Rusli, Elizabeth J Akin, Christopher A Baker, Shujun Liu, Fadia B Dib-Hajj, Stephen G Waxman, Sulayman D Dib-Hajj
Real-time imaging of axonal membrane protein life cycles. Nature protocols (2024)
Mohammad-Reza Ghovanloo, Philip R Effraim, Sidharth Tyagi, Peng Zhao, Sulayman D Dib-Hajj, Stephen G Waxman
Functionally-selective inhibition of threshold sodium currents and excitability in dorsal root ganglion neurons by cannabinol. Communications biology 7 (1) (2024)
Ana Paula Nascimento de Lima, Huiran Zhang, Lubin Chen, Philip R Effraim, Carolina Gomis-Perez, Xiaoyang Cheng, Jianying Huang, Stephen G Waxman, Sulayman D Dib-Hajj
Nav1.8 in small dorsal root ganglion neurons contributes to vincristine-induced mechanical allodynia. Brain : a journal of neurology (2024)
Mohammad-Reza Ghovanloo, Philip R Effraim, Sidharth Tyagi, Peng Zhao, Sulayman D Dib-Hajj, Stephen G Waxman
Functionally-selective inhibition of threshold sodium currents and excitability in dorsal root ganglion neurons by cannabinol. Communications biology 7 (1) (2024)
Ana Paula Nascimento de Lima, Huiran Zhang, Lubin Chen, Philip R Effraim, Carolina Gomis-Perez, Xiaoyang Cheng, Jianying Huang, Stephen G Waxman, Sulayman D Dib-Hajj
Nav1.8 in small dorsal root ganglion neurons contributes to vincristine-induced mechanical allodynia. Brain : a journal of neurology (2024)
Mohammad-Reza Ghovanloo, Philip R Effraim, Jun-Hui Yuan, Betsy R Schulman, Deborah S Jacobs, Sulayman D Dib-Hajj, Stephen G Waxman
Nav1.7 P610T mutation in two siblings with persistent ocular pain after corneal axon transection: impaired slow inactivation and hyperexcitable trigeminal neurons. Journal of neurophysiology 129 (3) (2023)
Mohammad-Reza Ghovanloo, Philip R Effraim, Jun-Hui Yuan, Betsy R Schulman, Deborah S Jacobs, Sulayman D Dib-Hajj, Stephen G Waxman
Nav1.7 P610T mutation in two siblings with persistent ocular pain after corneal axon transection: impaired slow inactivation and hyperexcitable trigeminal neurons. Journal of neurophysiology 129 (3) (2023)
Mohammad-Reza Ghovanloo, Philip R Effraim, Jun-Hui Yuan, Betsy R Schulman, Deborah S Jacobs, Sulayman D Dib-Hajj, Stephen G Waxman
Nav1.7 P610T mutation in two siblings with persistent ocular pain after corneal axon transection: impaired slow inactivation and hyperexcitable trigeminal neurons. Journal of neurophysiology 129 (3) (2023)
Margherita Marchi, Erika Salvi, Mirna Andelic, Elkadia Mehmeti, Ilaria D'Amato, Daniele Cazzato, Federica Chiappori, Raffaella Lombardi, Daniele Cartelli, Grazia Devigili, Eleonora Dalla Bella, Monique M Gerrits, Rowida Almomani, Rayaz Ahmed Malik, Milena Ślęczkowska, Anna Mazzeo, Luca Gentile, Sulayman D Dib-Hajj, Stephen G Waxman, Catharina G Faber, Eleonora Vecchio, Marina de Tommaso, Giuseppe Lauria
TRPA1 rare variants in chronic neuropathic and nociplastic pain patients. Pain (2023)
Sina Jami, Jennifer R Deuis, Tabea Klasfauseweh, Xiaoyang Cheng, Sergey Kurdyukov, Felicity Chung, Andrei L Okorokov, Shengnan Li, Jiangtao Zhang, Ben Cristofori-Armstrong, Mathilde R Israel, Robert J Ju, Samuel D Robinson, Peng Zhao, Lotten Ragnarsson, Åsa Andersson, Poanna Tran, Vanessa Schendel, Kirsten L McMahon, Hue N T Tran, Yanni K-Y Chin, Yifei Zhu, Junyu Liu, Theodore Crawford, Saipriyaa Purushothamvasan, Abdella M Habib, David A Andersson, Lachlan D Rash, John N Wood, Jing Zhao, Samantha J Stehbens, Mehdi Mobli, Tabea C Fricke, Daohua Jiang, James J Cox, Stephen G Waxman, Sulayman D Dib-Hajj, G Gregory Neely, Thomas Durek, Irina Vetter
Pain-causing stinging nettle toxins target TMEM233 to modulate Na V 1.7 function. Nature communications 14 (1) (2023)
Margherita Marchi, Erika Salvi, Mirna Andelic, Elkadia Mehmeti, Ilaria D'Amato, Daniele Cazzato, Federica Chiappori, Raffaella Lombardi, Daniele Cartelli, Grazia Devigili, Eleonora Dalla Bella, Monique M Gerrits, Rowida Almomani, Rayaz Ahmed Malik, Milena Ślęczkowska, Anna Mazzeo, Luca Gentile, Sulayman D Dib-Hajj, Stephen G Waxman, Catharina G Faber, Eleonora Vecchio, Marina de Tommaso, Giuseppe Lauria
TRPA1 rare variants in chronic neuropathic and nociplastic pain patients. Pain (2023)
Mirna Andelic, Erika Salvi, Stefania Marcuzzo, Margherita Marchi, Raffaella Lombardi, Daniele Cartelli, Daniele Cazzato, Elkadia Mehmeti, Andrea Gelemanovic, Matilde Paolini, Carlotta Pardo, Ilaria D'Amato, Janneke G J Hoeijmakers, Sulayman D Dib-Hajj, Stephen G Waxman, Catharina G Faber, Giuseppe Lauria Pinter
Integrative miRNA-mRNA profiling of human epidermis: unique signature of SCN9A painful neuropathy. Brain : a journal of neurology (2023)
Grant P Higerd, Sidharth Tyagi, Christopher A Baker, Shujun Liu, Fadia B Dib-Hajj, Sulayman D Dib-Hajj, Stephen G Waxman
Inflammation differentially controls transport of depolarizing Nav versus hyperpolarizing Kv channels to drive rat nociceptor activity. Proceedings of the National Academy of Sciences of the United States of America 120 (11) (2023)
Mohammad-Reza Ghovanloo, Philip R Effraim, Jun-Hui Yuan, Betsy R Schulman, Deborah S Jacobs, Sulayman D Dib-Hajj, Stephen G Waxman
Nav1.7 P610T mutation in two siblings with persistent ocular pain after corneal axon transection: impaired slow inactivation and hyperexcitable trigeminal neurons. Journal of neurophysiology 129 (3) (2023)
Grant P Higerd, Sidharth Tyagi, Christopher A Baker, Shujun Liu, Fadia B Dib-Hajj, Sulayman D Dib-Hajj, Stephen G Waxman
Inflammation differentially controls transport of depolarizing Nav versus hyperpolarizing Kv channels to drive rat nociceptor activity. Proceedings of the National Academy of Sciences of the United States of America 120 (11) (2023)
Margherita Marchi, Erika Salvi, Mirna Andelic, Elkadia Mehmeti, Ilaria D'Amato, Daniele Cazzato, Federica Chiappori, Raffaella Lombardi, Daniele Cartelli, Grazia Devigili, Eleonora Dalla Bella, Monique M Gerrits, Rowida Almomani, Rayaz Ahmed Malik, Milena Ślęczkowska, Anna Mazzeo, Luca Gentile, Sulayman D Dib-Hajj, Stephen G Waxman, Catharina G Faber, Eleonora Vecchio, Marina de Tommaso, Giuseppe Lauria
TRPA1 rare variants in chronic neuropathic and nociplastic pain patients. Pain (2023)
Mohammad-Reza Ghovanloo, Philip R Effraim, Jun-Hui Yuan, Betsy R Schulman, Deborah S Jacobs, Sulayman D Dib-Hajj, Stephen G Waxman
Nav1.7 P610T mutation in two siblings with persistent ocular pain after corneal axon transection: impaired slow inactivation and hyperexcitable trigeminal neurons. Journal of neurophysiology 129 (3) (2023)
Sina Jami, Jennifer R Deuis, Tabea Klasfauseweh, Xiaoyang Cheng, Sergey Kurdyukov, Felicity Chung, Andrei L Okorokov, Shengnan Li, Jiangtao Zhang, Ben Cristofori-Armstrong, Mathilde R Israel, Robert J Ju, Samuel D Robinson, Peng Zhao, Lotten Ragnarsson, Åsa Andersson, Poanna Tran, Vanessa Schendel, Kirsten L McMahon, Hue N T Tran, Yanni K-Y Chin, Yifei Zhu, Junyu Liu, Theodore Crawford, Saipriyaa Purushothamvasan, Abdella M Habib, David A Andersson, Lachlan D Rash, John N Wood, Jing Zhao, Samantha J Stehbens, Mehdi Mobli, Tabea C Fricke, Daohua Jiang, James J Cox, Stephen G Waxman, Sulayman D Dib-Hajj, G Gregory Neely, Thomas Durek, Irina Vetter
Pain-causing stinging nettle toxins target TMEM233 to modulate Na V 1.7 function. Nature communications 14 (1) (2023)
Margherita Marchi, Erika Salvi, Mirna Andelic, Elkadia Mehmeti, Ilaria D'Amato, Daniele Cazzato, Federica Chiappori, Raffaella Lombardi, Daniele Cartelli, Grazia Devigili, Eleonora Dalla Bella, Monique M Gerrits, Rowida Almomani, Rayaz Ahmed Malik, Milena Ślęczkowska, Anna Mazzeo, Luca Gentile, Sulayman D Dib-Hajj, Stephen G Waxman, Catharina G Faber, Eleonora Vecchio, Marina de Tommaso, Giuseppe Lauria
TRPA1 rare variants in chronic neuropathic and nociplastic pain patients. Pain (2023)
Sina Jami, Jennifer R Deuis, Tabea Klasfauseweh, Xiaoyang Cheng, Sergey Kurdyukov, Felicity Chung, Andrei L Okorokov, Shengnan Li, Jiangtao Zhang, Ben Cristofori-Armstrong, Mathilde R Israel, Robert J Ju, Samuel D Robinson, Peng Zhao, Lotten Ragnarsson, Åsa Andersson, Poanna Tran, Vanessa Schendel, Kirsten L McMahon, Hue N T Tran, Yanni K-Y Chin, Yifei Zhu, Junyu Liu, Theodore Crawford, Saipriyaa Purushothamvasan, Abdella M Habib, David A Andersson, Lachlan D Rash, John N Wood, Jing Zhao, Samantha J Stehbens, Mehdi Mobli, Tabea C Fricke, Daohua Jiang, James J Cox, Stephen G Waxman, Sulayman D Dib-Hajj, G Gregory Neely, Thomas Durek, Irina Vetter
Pain-causing stinging nettle toxins target TMEM233 to modulate Na V 1.7 function. Nature communications 14 (1) (2023)
Mohammad-Reza Ghovanloo, Philip R Effraim, Jun-Hui Yuan, Betsy R Schulman, Deborah S Jacobs, Sulayman D Dib-Hajj, Stephen G Waxman
Nav1.7 P610T mutation in two siblings with persistent ocular pain after corneal axon transection: impaired slow inactivation and hyperexcitable trigeminal neurons. Journal of neurophysiology 129 (3) (2023)
Margherita Marchi, Erika Salvi, Mirna Andelic, Elkadia Mehmeti, Ilaria D'Amato, Daniele Cazzato, Federica Chiappori, Raffaella Lombardi, Daniele Cartelli, Grazia Devigili, Eleonora Dalla Bella, Monique M Gerrits, Rowida Almomani, Rayaz Ahmed Malik, Milena Ślęczkowska, Anna Mazzeo, Luca Gentile, Sulayman D Dib-Hajj, Stephen G Waxman, Catharina G Faber, Eleonora Vecchio, Marina de Tommaso, Giuseppe Lauria
TRPA1 rare variants in chronic neuropathic and nociplastic pain patients. Pain (2023)
Sina Jami, Jennifer R Deuis, Tabea Klasfauseweh, Xiaoyang Cheng, Sergey Kurdyukov, Felicity Chung, Andrei L Okorokov, Shengnan Li, Jiangtao Zhang, Ben Cristofori-Armstrong, Mathilde R Israel, Robert J Ju, Samuel D Robinson, Peng Zhao, Lotten Ragnarsson, Åsa Andersson, Poanna Tran, Vanessa Schendel, Kirsten L McMahon, Hue N T Tran, Yanni K-Y Chin, Yifei Zhu, Junyu Liu, Theodore Crawford, Saipriyaa Purushothamvasan, Abdella M Habib, David A Andersson, Lachlan D Rash, John N Wood, Jing Zhao, Samantha J Stehbens, Mehdi Mobli, Tabea C Fricke, Daohua Jiang, James J Cox, Stephen G Waxman, Sulayman D Dib-Hajj, G Gregory Neely, Thomas Durek, Irina Vetter
Pain-causing stinging nettle toxins target TMEM233 to modulate Na V 1.7 function. Nature communications 14 (1) (2023)
Grant P Higerd, Sidharth Tyagi, Christopher A Baker, Shujun Liu, Fadia B Dib-Hajj, Sulayman D Dib-Hajj, Stephen G Waxman
Inflammation differentially controls transport of depolarizing Nav versus hyperpolarizing Kv channels to drive rat nociceptor activity. Proceedings of the National Academy of Sciences of the United States of America 120 (11) (2023)
Mohammad-Reza Ghovanloo, Philip R Effraim, Jun-Hui Yuan, Betsy R Schulman, Deborah S Jacobs, Sulayman D Dib-Hajj, Stephen G Waxman
Nav1.7 P610T mutation in two siblings with persistent ocular pain after corneal axon transection: impaired slow inactivation and hyperexcitable trigeminal neurons. Journal of neurophysiology 129 (3) (2023)
Mohammad-Reza Ghovanloo, Sidharth Tyagi, Peng Zhao, Philip R Effraim, Sulayman D Dib-Hajj, Stephen G Waxman
Sodium currents in naïve mouse dorsal root ganglion neurons: No major differences between sexes. Channels (Austin, Tex.) 18 (1) (2023)
Sina Jami, Jennifer R Deuis, Tabea Klasfauseweh, Xiaoyang Cheng, Sergey Kurdyukov, Felicity Chung, Andrei L Okorokov, Shengnan Li, Jiangtao Zhang, Ben Cristofori-Armstrong, Mathilde R Israel, Robert J Ju, Samuel D Robinson, Peng Zhao, Lotten Ragnarsson, Åsa Andersson, Poanna Tran, Vanessa Schendel, Kirsten L McMahon, Hue N T Tran, Yanni K-Y Chin, Yifei Zhu, Junyu Liu, Theodore Crawford, Saipriyaa Purushothamvasan, Abdella M Habib, David A Andersson, Lachlan D Rash, John N Wood, Jing Zhao, Samantha J Stehbens, Mehdi Mobli, Tabea C Fricke, Daohua Jiang, James J Cox, Stephen G Waxman, Sulayman D Dib-Hajj, G Gregory Neely, Thomas Durek, Irina Vetter
Pain-causing stinging nettle toxins target TMEM233 to modulate Na V 1.7 function. Nature communications 14 (1) (2023)
Philip R Effraim, Mark Estacion, Peng Zhao, Daniel Sosniak, Stephen G Waxman, Sulayman D Dib-Hajj
Fibroblast growth factor homologous factor 2 attenuates excitability of DRG neurons. Journal of neurophysiology 128 (5) (2022)
Mohammad-Reza Ghovanloo, Mark Estacion, Grant P Higerd, Peng Zhao, Sulayman D Dib-Hajj, Stephen G Waxman
Inhibition of sodium conductance by cannabigerol contributes to a reduction of dorsal root ganglion neuron excitability. British journal of pharmacology 179 (15) (2022)
Grant P Higerd-Rusli, Matthew Alsaloum, Sidharth Tyagi, Nivedita Sarveswaran, Mark Estacion, Elizabeth J Akin, Sulayman D Dib-Hajj, Shujun Liu, Daniel Sosniak, Peng Zhao, Stephen G Waxman
Depolarizing Na V and hyperpolarizing K V channels are co-trafficked in sensory neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience (2022)
Ralf Baron, Anthony H Dickenson, Margarita Calvo, Sulayman D Dib-Hajj, David L H Bennett
Maximizing treatment efficacy through patient stratification in neuropathic pain trials. Nature reviews. Neurology (2022)
Roberta Gualdani, Philippe Gailly, Jun-Hui Yuan, Xavier Yerna, Giulia Di Stefano, Andrea Truini, Giorgio Cruccu, Sulayman D Dib-Hajj, Stephen G Waxman
A TRPM7 mutation linked to familial trigeminal neuralgia: Omega current and hyperexcitability of trigeminal ganglion neurons. Proceedings of the National Academy of Sciences of the United States of America 119 (38) (2022)
Matthew Alsaloum, Julie I R Labau, Daniel Sosniak, Peng Zhao, Rowida Almomani, Monique M Gerrits, Janneke G J Hoeijmakers, Giuseppe Lauria Pinter, Catharina G Faber, Stephen G Waxman, Sulayman D Dib-Hajj
A novel gain-of-function sodium channel β2 subunit mutation in idiopathic small fiber neuropathy. Journal of neurophysiology 126 (3) (2021)
Jun-Hui Yuan, Mark Estacion, Malgorzata A Mis, Brian S Tanaka, Betsy R Schulman, Lubin Chen, Shujun Liu, Fadia B Dib-Hajj, Sulayman D Dib-Hajj, Stephen G Waxman
KCNQ variants and pain modulation: a missense variant in Kv7.3 contributes to pain resilience. Brain communications 3 (3) (2021)
Elizabeth J Akin, Matthew Alsaloum, Grant P Higerd, Shujun Liu, Peng Zhao, Fadia B Dib-Hajj, Stephen G Waxman, Sulayman D Dib-Hajj
Paclitaxel increases axonal localization and vesicular trafficking of Nav1.7. Brain : a journal of neurology 144 (6) (2021)
Elizabeth J Akin, Grant P Higerd, Malgorzata A Mis, Brian S Tanaka, Talia Adi, Shujun Liu, Fadia B Dib-Hajj, Stephen G Waxman, Sulayman D Dib-Hajj
Building sensory axons: Delivery and distribution of NaV1.7 channels and effects of inflammatory mediators. Science advances 5 (10) (2019)
Lubin Chen, Jianying Huang, Peng Zhao, Anna-Karin Persson, Fadia B Dib-Hajj, Xiaoyang Cheng, Andrew Tan, Stephen G Waxman, Sulayman D Dib-Hajj
Conditional knockout of NaV1.6 in adult mice ameliorates neuropathic pain. Scientific reports 8 (1) (2018)
Lukas Hofmann, Dorothea Hose, Anne Grießhammer, Robert Blum, Frank Döring, Sulayman D Dib-Hajj, Stephen Waxman, Claudia Sommer, Erhard Wischmeyer, Nurcan Üçeyler
Characterization of small fiber pathology in a mouse model of Fabry disease. eLife 7 (2018)
Jianying Huang, Malgorzata A Mis, Brian Tanaka, Talia Adi, Mark Estacion, Shujun Liu, Suellen Walker, Sulayman D Dib-Hajj, Stephen G Waxman
Atypical changes in DRG neuron excitability and complex pain phenotype associated with a Nav1.7 mutation that massively hyperpolarizes activation. Scientific reports 8 (1) (2018)
Malgorzata A Mis, Yang Yang, Brian S Tanaka, Carolina Gomis-Pérez, Shujun Liu, Fadia B Dib-Hajj, Talia Adi, Rolando García Milian, Betsy R Schulman, Sulayman D Dib-Hajj, Stephen G Waxman
Resilience to Pain: A Peripheral Component Identified Using Induced Pluripotent Stem Cells and Dynamic Clamp. The Journal of neuroscience : the official journal of the Society for Neuroscience 39 (3) (2018)
Choochai Nettuwakul, Oranud Praditsap, Nunghathai Sawasdee, Nanyawan Rungroj, Katesirin Ruamyod, Wattana B Watanapa, Mutita Junking, Sittideth Sangnual, Suchai Sritippayawan, Boonyarit Cheunsuchon, Duangporn Chuawattana, Santi Rojsatapong, Wipada Chaowagul, Sulayman D Dib-Hajj, Stephen G Waxman, Pa-Thai Yenchitsomanus
Loss-of-function mutations of SCN10A encoding NaV1.8 α subunit of voltage-gated sodium channel in patients with human kidney stone disease. Scientific reports 8 (1) (2018)
Yang Yang, Jianying Huang, Malgorzata A Mis, Mark Estacion, Lawrence Macala, Palak Shah, Betsy R Schulman, Daniel B Horton, Sulayman D Dib-Hajj, Stephen G Waxman
Nav1.7-A1632G Mutation from a Family with Inherited Erythromelalgia: Enhanced Firing of Dorsal Root Ganglia Neurons Evoked by Thermal Stimuli. The Journal of neuroscience : the official journal of the Society for Neuroscience 36 (28) (2017)
Jianying Huang, Yang Yang, Sulayman D Dib-Hajj, Michael van Es, Peng Zhao, Jody Salomon, Joost P H Drenth, Stephen G Waxman
Depolarized inactivation overcomes impaired activation to produce DRG neuron hyperexcitability in a Nav1.7 mutation in a patient with distal limb pain. The Journal of neuroscience : the official journal of the Society for Neuroscience 34 (37) (2015)