PHD :: Department of Biophysics and Biochemistry, Graduate School of Science; Center for Experimental Medicine and Systems Biology, Institute of Medical Science

Publications

Daisuke Sugiura, Il-Mi Okazaki, Takeo K Maeda, Takumi Maruhashi, Kenji Shimizu, Rieko Arakaki, Tatsuya Takemoto, Naozumi Ishimaru, Taku Okazaki
PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity. Nature immunology 23 (3) (2022)
Tomonori Kaifu, Rikio Yabe, Takumi Maruhashi, Soo-Hyun Chung, Hiroaki Tateno, Noriyuki Fujikado, Jun Hirabayashi, Yoichiro Iwakura
DCIR and its ligand asialo-biantennary N-glycan regulate DC function and osteoclastogenesis. The Journal of experimental medicine 218 (12) (2021)
Kenji Shimizu, Daisuke Sugiura, Il-Mi Okazaki, Takumi Maruhashi, Tatsuya Takemoto, Taku Okazaki
PD-1 preferentially inhibits the activation of low-affinity T cells. Proceedings of the National Academy of Sciences of the United States of America 118 (35) (2021)
Takumi Maruhashi, Daisuke Sugiura, Il-Mi Okazaki, Taku Okazaki
LAG-3: from molecular functions to clinical applications. Journal for immunotherapy of cancer 8 (2) (2021)
Rikio Yabe, Soo-Hyun Chung, Masanori A Murayama, Sachiko Kubo, Kenji Shimizu, Yukiko Akahori, Takumi Maruhashi, Akimasa Seno, Tomonori Kaifu, Shinobu Saijo, Yoichiro Iwakura
TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens. Nature communications 12 (1) (2021)
Daisuke Sugiura, Takumi Maruhashi, Il-Mi Okazaki, Kenji Shimizu, Takeo K Maeda, Tatsuya Takemoto, Taku Okazaki
Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses. Science (New York, N.Y.) 364 (6440) (2019)
Natsumi Maeda, Takumi Maruhashi, Daisuke Sugiura, Kenji Shimizu, Il-Mi Okazaki, Taku Okazaki
Glucocorticoids potentiate the inhibitory capacity of programmed cell death 1 by up-regulating its expression on T cells. The Journal of biological chemistry 294 (52) (2019)
Takumi Maruhashi, Il-Mi Okazaki, Daisuke Sugiura, Suzuka Takahashi, Takeo K Maeda, Kenji Shimizu, Taku Okazaki
LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII. Nature immunology 19 (12) (2018)

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Publication Activity (10 Years)

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Takumi Maruhashi