Viktor Brabec (V Brabec)

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 61

Top Venues

Journal of medicinal chemistry

Chemistry (Weinheim an der Bergstrasse, Germany)

Inorganic chemistry

Dalton transactions (Cambridge, England : 2003)

Palacký University, Olomouc

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Palacký University, Olomouc Jan 01 2008

Czechia

Professor :: Department of Biophysics, Faculty of Science

Institute of Biophysics, Czech Academy of Sciences Jan 01 1973

Czechia

head of the Department :: Department of Molecular Biophysics and Pharmacology

Publications

Hualong Song, Hana Kostrhunova, Jakub Cervinka, Julie V Macpherson, Jaroslav Malina, Teena Rajan, Roger M Phillips, Miles Lewis Postings, Samantha L Shepherd, Xuejian Zhang, Viktor Brabec, Nicola J Rogers, Peter Scott
Dicobalt(ii) helices kill colon cancer cells via enantiomer-specific mechanisms; DNA damage or microtubule disruption. Chemical science 15 (28) (2024)
Hualong Song, Hana Kostrhunova, Jakub Cervinka, Julie V Macpherson, Jaroslav Malina, Teena Rajan, Roger M Phillips, Miles Lewis Postings, Samantha L Shepherd, Xuejian Zhang, Viktor Brabec, Nicola J Rogers, Peter Scott
Dicobalt(ii) helices kill colon cancer cells via enantiomer-specific mechanisms; DNA damage or microtubule disruption. Chemical science 15 (28) (2024)
Lenka Marková, Moumita Maji, Hana Kostrhunova, Vojtěch Novohradský, Jana Kasparkova, Dan Gibson, Viktor Brabec
Multiaction Pt(IV) Prodrugs Releasing Cisplatin and Dasatinib Are Potent Anticancer and Anti-Invasive Agents Displaying Synergism between the Two Drugs. Journal of medicinal chemistry (2024)
Lenka Marková, Moumita Maji, Hana Kostrhunova, Vojtěch Novohradský, Jana Kasparkova, Dan Gibson, Viktor Brabec
Multiaction Pt(IV) Prodrugs Releasing Cisplatin and Dasatinib Are Potent Anticancer and Anti-Invasive Agents Displaying Synergism between the Two Drugs. Journal of medicinal chemistry 67 (11) (2024)
Jana Kasparkova, Alba Hernández-García, Hana Kostrhunova, Marta Goicuría, Vojtěch Novohradský, Delia Bautista, Lenka Marková, María Dolores Santana, Viktor Brabec, José Ruiz
Novel 2-(5-Arylthiophen-2-yl)-benzoazole Cyclometalated Iridium(III) dppz Complexes Exhibit Selective Phototoxicity in Cancer Cells by Lysosomal Damage and Oncosis. Journal of medicinal chemistry 67 (1) (2023)
Jana Kasparkova, Alba Hernández-García, Hana Kostrhunova, Marta Goicuría, Vojtěch Novohradský, Delia Bautista, Lenka Marková, María Dolores Santana, Viktor Brabec, José Ruiz
Novel 2-(5-Arylthiophen-2-yl)-benzoazole Cyclometalated Iridium(III) dppz Complexes Exhibit Selective Phototoxicity in Cancer Cells by Lysosomal Damage and Oncosis. Journal of medicinal chemistry 67 (1) (2023)
Hana Kostrhunova, Brondwyn S McGhie, Lenka Marková, Olga Novakova, Jana Kasparkova, Janice Rae Aldrich-Wright, Viktor Brabec
Platinum(IV) Derivatives of [Pt(1 S ,2 S -diaminocyclohexane)(5,6-dimethyl-1,10-phenanthroline)] with Diclofenac Ligands in the Axial Positions: A New Class of Potent Multi-action Agents Exhibiting Selectivity to Cancer Cells. Journal of medicinal chemistry (2023)
Jana Kasparkova, Alba Hernández-García, Hana Kostrhunova, Marta Goicuría, Vojtěch Novohradský, Delia Bautista, Lenka Marková, María Dolores Santana, Viktor Brabec, José Ruiz
Novel 2-(5-Arylthiophen-2-yl)-benzoazole Cyclometalated Iridium(III) dppz Complexes Exhibit Selective Phototoxicity in Cancer Cells by Lysosomal Damage and Oncosis. Journal of medicinal chemistry 67 (1) (2023)
Jaroslav Malina, Hana Kostrhunova, Peter Scott, Viktor Brabec
Metallohelices stabilize DNA three-way junctions and induce DNA damage in cancer cells. Nucleic acids research (2023)
Jana Kasparkova, Alba Hernández-García, Hana Kostrhunova, Marta Goicuría, Vojtěch Novohradský, Delia Bautista, Lenka Marková, María Dolores Santana, Viktor Brabec, José Ruiz
Novel 2-(5-Arylthiophen-2-yl)-benzoazole Cyclometalated Iridium(III) dppz Complexes Exhibit Selective Phototoxicity in Cancer Cells by Lysosomal Damage and Oncosis. Journal of medicinal chemistry 67 (1) (2023)
Jana Kasparkova, Alba Hernández-García, Hana Kostrhunova, Marta Goicuría, Vojtěch Novohradský, Delia Bautista, Lenka Marková, María Dolores Santana, Viktor Brabec, José Ruiz
Novel 2-(5-Arylthiophen-2-yl)-benzoazole Cyclometalated Iridium(III) dppz Complexes Exhibit Selective Phototoxicity in Cancer Cells by Lysosomal Damage and Oncosis. Journal of medicinal chemistry (2023)
Jitka Prachařová, Hana Kostrhunova, Alessandra Barbanente, Nicola Margiotta, Viktor Brabec
The mechanism of antiproliferative activity of the oxaliplatin pyrophosphate derivative involves its binding to nuclear DNA in cancer cells. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry (2023)
James P C Coverdale, Hana Kostrhunova, Lenka Marková, Hualong Song, Miles Lewis Postings, Hannah E Bridgewater, Viktor Brabec, Nicola J Rogers, Peter Scott
Triplex metallohelices have enantiomer-dependent mechanisms of action in colon cancer cells. Dalton transactions (Cambridge, England : 2003) (2023)
Alba Hernández-García, Lenka Marková, María Dolores Santana, Jitka Prachařová, Delia Bautista, Hana Kostrhunová, Vojtěch Novohradský, Viktor Brabec, José Ruiz, Jana Kasparkova
Cyclometalated Benzimidazole Osmium(II) Complexes with Antiproliferative Activity in Cancer Cells Disrupt Calcium Homeostasis. Inorganic chemistry (2023)
Vojtěch Novohradský, Alicia Marco, Lenka Marková, Natalia Cutillas, José Ruiz, Viktor Brabec
Ir(III) Compounds Containing a Terdentate Ligand Are Potent Inhibitors of Proliferation and Effective Antimetastatic Agents in Aggressive Triple-Negative Breast Cancer Cells. Journal of medicinal chemistry (2023)
Sebastian W Schleser, Oleksandr Krytovych, Tim Ziegelmeier, Elisabeth Groß, Jana Kasparkova, Viktor Brabec, Thomas Weber, Rainer Schobert, Thomas Mueller
Palladium and Platinum Complexes of the Antimetabolite Fludarabine with Vastly Enhanced Selectivity for Tumour over Non-Malignant Cells. Molecules (Basel, Switzerland) 28 (13) (2023)
James P C Coverdale, Hana Kostrhunova, Lenka Marková, Hualong Song, Miles Lewis Postings, Hannah E Bridgewater, Viktor Brabec, Nicola J Rogers, Peter Scott
Triplex metallohelices have enantiomer-dependent mechanisms of action in colon cancer cells. Dalton transactions (Cambridge, England : 2003) 52 (20) (2023)
James P C Coverdale, Hana Kostrhunova, Lenka Marková, Hualong Song, Miles Lewis Postings, Hannah E Bridgewater, Viktor Brabec, Nicola J Rogers, Peter Scott
Triplex metallohelices have enantiomer-dependent mechanisms of action in colon cancer cells. Dalton transactions (Cambridge, England : 2003) 52 (20) (2023)
Jana Kasparkova, Alba Hernández-García, Hana Kostrhunova, Marta Goicuría, Vojtěch Novohradský, Delia Bautista, Lenka Marková, María Dolores Santana, Viktor Brabec, José Ruiz
Novel 2-(5-Arylthiophen-2-yl)-benzoazole Cyclometalated Iridium(III) dppz Complexes Exhibit Selective Phototoxicity in Cancer Cells by Lysosomal Damage and Oncosis. Journal of medicinal chemistry 67 (1) (2023)
Jana Kasparkova, Hana Kostrhunova, Vojtech Novohradsky, Lili Ma, Guangyu Zhu, Elena R Milaeva, Alexender A Shtill, Robin Vinck, Gilles Gasser, Viktor Brabec, Alexey A Nazarov
Is antitumor Pt(IV) complex containing two axial lonidamine ligands a true dual- or multi-action prodrug? Metallomics : integrated biometal science 14 (7) (2022)
Jakub Cervinka, Alberto Gobbo, Lorenzo Biancalana, Lenka Marková, Vojtěch Novohradský, Massimo Guelfi, Stefano Zacchini, Jana Kasparkova, Viktor Brabec, Fabio Marchetti
Ruthenium(II)-Tris-pyrazolylmethane Complexes Inhibit Cancer Cell Growth by Disrupting Mitochondrial Calcium Homeostasis. Journal of medicinal chemistry 65 (15) (2022)
Jaroslav Malina, Hana Kostrhunova, Vojtech Novohradsky, Peter Scott, Viktor Brabec
Metallohelix vectors for efficient gene delivery via cationic DNA nanoparticles. Nucleic acids research 50 (2) (2022)
Monika Hreusova, Vojtěch Novohradský, Lenka Marková, Hana Kostrhunova, Ivan Potočňák, Viktor Brabec, Jana Kasparkova
Gallium(III) Complex with Cloxyquin Ligands Induces Ferroptosis in Cancer Cells and Is a Potent Agent against Both Differentiated and Tumorigenic Cancer Stem Rhabdomyosarcoma Cells. Bioinorganic chemistry and applications 2022 (2022)
Jana Kasparkova, Hana Kostrhunova, Vojtech Novohradsky, Аlexey A Logvinov, Viktor V Temnov, Nataliya E Borisova, Tatiana A Podrugina, Lenka Markova, Pavel Starha, Alexey A Nazarov, Viktor Brabec
Novel cis-Pt(II) Complexes with Alkylpyrazole Ligands: Synthesis, Characterization, and Unusual Mode of Anticancer Action. Bioinorganic chemistry and applications 2022 (2022)
Hualong Song, Nicola J Rogers, Viktor Brabec, Guy J Clarkson, James P C Coverdale, Hana Kostrhunova, Roger M Phillips, Miles Lewis Postings, Samantha L Shepherd, Peter Scott
Triazole-based, optically-pure metallosupramolecules; highly potent and selective anticancer compounds. Chemical communications (Cambridge, England) 56 (47) (2021)
Monika Hreusova, Viktor Brabec, Olga Novakova
Processing and Bypass of a Site-Specific DNA Adduct of the Cytotoxic Platinum-Acridinylthiourea Conjugate by Polymerases Involved in DNA Repair: Biochemical and Thermodynamic Aspects. International journal of molecular sciences 22 (19) (2021)
Claudia Schmidt, Tomer Babu, Hana Kostrhunova, Annika Timm, Uttara Basu, Ingo Ott, Valentina Gandin, Viktor Brabec, Dan Gibson
Are Pt(IV) Prodrugs That Release Combretastatin A4 True Multi-action Prodrugs? Journal of medicinal chemistry 64 (15) (2021)
Lukáš Masaryk, Ivan Nemec, Jana Kasparkova, Viktor Brabec, Pavel Štarha
Unexpected solution behaviour of ester-functionalized half-sandwich Ru(II) and Ir(III) complexes. Dalton transactions (Cambridge, England : 2003) 50 (23) (2021)
Lorenzo Biancalana, Hana Kostrhunova, Lucinda K Batchelor, Mouna Hadiji, Ilaria Degano, Guido Pampaloni, Stefano Zacchini, Paul J Dyson, Viktor Brabec, Fabio Marchetti
Hetero-Bis-Conjugation of Bioactive Molecules to Half-Sandwich Ruthenium(II) and Iridium(III) Complexes Provides Synergic Effects in Cancer Cell Cytotoxicity. Inorganic chemistry 60 (13) (2021)
Huayun Shi, Jana Kasparkova, Clément Soulié, Guy J Clarkson, Cinzia Imberti, Olga Novakova, Martin J Paterson, Viktor Brabec, Peter J Sadler
DNA-Intercalative Platinum Anticancer Complexes Photoactivated by Visible Light. Chemistry (Weinheim an der Bergstrasse, Germany) 27 (41) (2021)
Vojtěch Novohradský, Lenka Marková, Hana Kostrhunova, Jana Kasparkova, José Ruiz, Vicente Marchán, Viktor Brabec
A Cyclometalated IrIII Complex Conjugated to a Coumarin Derivative Is a Potent Photodynamic Agent against Prostate Differentiated and Tumorigenic Cancer Stem Cells. Chemistry (Weinheim an der Bergstrasse, Germany) 27 (33) (2021)
Jaroslav Malina, Hana Kostrhunova, Peter Scott, Viktor Brabec
FeII Metallohelices Stabilize DNA G-Quadruplexes and Downregulate the Expression of G-Quadruplex-Regulated Oncogenes. Chemistry (Weinheim an der Bergstrasse, Germany) 27 (45) (2021)
Ondrej Hrabina, Jaroslav Malina, Peter Scott, Viktor Brabec
Cationic FeII Triplex-Forming Metallohelices as DNA Bulge Binders. Chemistry (Weinheim an der Bergstrasse, Germany) 26 (69) (2020)
D Khattib, M Ishan, Subhendu Karmakar, Hana Kostrhunova, Viktor Brabec, Dan Gibson
Oxidation of cis-Diamminediacetato PtII with Hydrogen Peroxide Can Give Rise to Two Isomeric PtIV Products. Chemistry (Weinheim an der Bergstrasse, Germany) 26 (43) (2020)
Hualong Song, Simon J Allison, Viktor Brabec, Hannah E Bridgewater, Jana Kasparkova, Hana Kostrhunova, Vojtěch Novohradský, Roger M Phillips, Jitka Prachařová, Nicola J Rogers, Samantha L Shepherd, Peter Scott
Glycoconjugated Metallohelices have Improved Nuclear Delivery and Suppress Tumour Growth In Vivo. Angewandte Chemie (International ed. in English) 59 (34) (2020)
Subhendu Karmakar, Hana Kostrhunova, Tereza Ctvrtlikova, Vojtěch Novohradský, Dan Gibson, Viktor Brabec
Platinum(IV)-Estramustine Multiaction Prodrugs Are Effective Antiproliferative Agents against Prostate Cancer Cells. Journal of medicinal chemistry 63 (22) (2020)
Ondrej Hrabina, Jaroslav Malina, Hana Kostrhunova, Vojtěch Novohradský, Jitka Prachařová, Nicola J Rogers, Daniel H Simpson, Peter Scott, Viktor Brabec
Optically Pure Metallohelices That Accumulate in Cell Nuclei, Condense/Aggregate DNA, and Inhibit Activities of DNA Processing Enzymes. Inorganic chemistry 59 (5) (2020)
Monika Hreusova, Olga Novakova, Viktor Brabec
Thermodynamic Insights by Microscale Thermophoresis into Translesion DNA Synthesis Catalyzed by DNA Polymerases Across a Lesion of Antitumor Platinum-Acridine Complex. International journal of molecular sciences 21 (20) (2020)
Jaroslav Malina, Nicholas P Farrell, Viktor Brabec
Substitution-Inert Polynuclear Platinum Complexes Inhibit Reverse Transcription Preferentially in RNA Triplex-Forming Templates. Inorganic chemistry 59 (20) (2020)
Jaroslav Malina, Peter Scott, Viktor Brabec
Shape-Selective Targeting on RNA Bulges by Peptidomimetic Metallohelices. Chemistry (Weinheim an der Bergstrasse, Germany) 26 (38) (2020)
James D Hoeschele, Jana Kasparkova, Hana Kostrhunova, Olga Novakova, Jitka Prachařová, Paul Pineau, Viktor Brabec
Synthesis, antiproliferative activity in cancer cells and DNA interaction studies of [Pt(cis-1,3-diaminocycloalkane)Cl2] analogs. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 25 (6) (2020)
Hana Kostrhunova, Juraj Zajac, Lenka Marková, Viktor Brabec, Jana Kasparkova
A Multi-action PtIV Conjugate with Oleate and Cinnamate Ligands Targets Human Epithelial Growth Factor Receptor HER2 in Aggressive Breast Cancer Cells. Angewandte Chemie (International ed. in English) 59 (47) (2020)
Juraj Zajac, Vojtěch Novohradský, Lenka Marková, Viktor Brabec, Jana Kasparkova
Platinum (IV) Derivatives with Cinnamate Axial Ligands as Potent Agents Against Both Differentiated and Tumorigenic Cancer Stem Rhabdomyosarcoma Cells. Angewandte Chemie (International ed. in English) 59 (8) (2020)
Francisco J Ballester, Enrique Ortega, Vanesa Porto, Hana Kostrhunova, Nerea Davila-Ferreira, Delia Bautista, Viktor Brabec, Fernando Domínguez, María Dolores Santana, José Ruiz
New half-sandwich ruthenium(ii) complexes as proteosynthesis inhibitors in cancer cells. Chemical communications (Cambridge, England) 55 (8) (2019)
Hana Kostrhunova, Juraj Zajac, Vojtech Novohradsky, Jana Kasparkova, Jaroslav Malina, Janice R Aldrich-Wright, Emanuele Petruzzella, Roman Sirota, Dan Gibson, Viktor Brabec
A Subset of New Platinum Antitumor Agents Kills Cells by a Multimodal Mechanism of Action Also Involving Changes in the Organization of the Microtubule Cytoskeleton. Journal of medicinal chemistry 62 (10) (2019)
Jaroslav Malina, Klára Čechová, Nicholas P Farrell, Viktor Brabec
Substitution-Inert Polynuclear Platinum Complexes with Dangling Amines: Condensation/Aggregation of Nucleic Acids and Inhibition of DNA-Related Enzymatic Activities. Inorganic chemistry 58 (10) (2019)
Ondrej Hrabina, Viktor Brabec, Olga Novakova
Translesion DNA Synthesis Across Lesions Induced by Oxidative Products of Pyrimidines: An Insight into the Mechanism by Microscale Thermophoresis. International journal of molecular sciences 20 (20) (2019)
Vojtech Novohradsky, Lenka Markova, Hana Kostrhunova, Zdeněk Trávníček, Viktor Brabec, Jana Kasparkova
An anticancer Os(II) bathophenanthroline complex as a human breast cancer stem cell-selective, mammosphere potent agent that kills cells by necroptosis. Scientific reports 9 (1) (2019)
Madeleine Gold, Yusufi Mujahid, Khursheed Ahmed, Hana Kostrhunova, Jana Kasparkova, Viktor Brabec, Bernhard Biersack, Rainer Schobert
A new 4-(pyridinyl)-4H-benzo[g]chromene-5,10-dione ruthenium(II) complex inducing senescence in 518A2 melanoma cells. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 24 (5) (2019)
Daniel H Simpson, Alexia Hapeshi, Nicola J Rogers, Viktor Brabec, Guy J Clarkson, David J Fox, Ondrej Hrabina, Gemma L Kay, Andrew K King, Jaroslav Malina, Andrew D Millard, John Moat, David I Roper, Hualong Song, Nicholas R Waterfield, Peter Scott
Metallohelices that kill Gram-negative pathogens using intracellular antimicrobial peptide pathways. Chemical science 10 (42) (2019)
Hana Kostrhunova, Emanuele Petruzzella, Dan Gibson, Jana Kasparkova, Viktor Brabec
An Anticancer PtIV Prodrug That Acts by Mechanisms Involving DNA Damage and Different Epigenetic Effects. Chemistry (Weinheim an der Bergstrasse, Germany) 25 (20) (2019)
Vojtech Novohradsky, Anna Rovira, Cormac Hally, Alex Galindo, Gloria Vigueras, Albert Gandioso, Marie Svitelova, Roger Bresolí-Obach, Hana Kostrhunova, Lenka Markova, Jana Kasparkova, Santi Nonell, José Ruiz, Viktor Brabec, Vicente Marchán
Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated IrIII Complex Conjugated to a Far-Red Emitting Coumarin. Angewandte Chemie (International ed. in English) 58 (19) (2019)
Hualong Song, Nicola J Rogers, Simon J Allison, Viktor Brabec, Hannah Bridgewater, Hana Kostrhunova, Lenka Markova, Roger M Phillips, Emma C Pinder, Samantha L Shepherd, Lawrence S Young, Juraj Zajac, Peter Scott
Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices via post-assembly modification. Chemical science 10 (37) (2019)
Jaroslav Malina, Nicholas P Farrell, Viktor Brabec
Substitution-Inert Polynuclear Platinum Complexes Act as Potent Inducers of Condensation/Aggregation of Short Single- and Double-Stranded DNA and RNA Oligonucleotides. Chemistry (Weinheim an der Bergstrasse, Germany) 25 (12) (2019)
Jitka Pracharova, Gloria Vigueras, Vojtech Novohradsky, Natalia Cutillas, Christoph Janiak, Hana Kostrhunova, Jana Kasparkova, José Ruiz, Viktor Brabec
Exploring the Effect of Polypyridyl Ligands on the Anticancer Activity of Phosphorescent Iridium(III) Complexes: From Proteosynthesis Inhibitors to Photodynamic Therapy Agents. Chemistry (Weinheim an der Bergstrasse, Germany) 24 (18) (2018)
Jaroslav Malina, Nicholas P Farrell, Viktor Brabec
Substitution-Inert Polynuclear Platinum Complexes That Inhibit the Activity of DNA Polymerase in Triplex-Forming Templates. Angewandte Chemie (International ed. in English) 57 (28) (2018)
Jan Hormann, Jaroslav Malina, Oliver Lemke, Max J Hülsey, Stefanie Wedepohl, Jan Potthoff, Claudia Schmidt, Ingo Ott, Bettina G Keller, Viktor Brabec, Nora Kulak
Multiply Intercalator-Substituted Cu(II) Cyclen Complexes as DNA Condensers and DNA/RNA Synthesis Inhibitors. Inorganic chemistry 57 (9) (2018)
Tobias Rehm, Matthias Rothemund, Alexander Bär, Thomas Dietel, Rhett Kempe, Hana Kostrhunova, Viktor Brabec, Jana Kasparkova, Rainer Schobert
N,N-Dialkylbenzimidazol-2-ylidene platinum complexes - effects of alkyl residues and ancillary cis-ligands on anticancer activity. Dalton transactions (Cambridge, England : 2003) 47 (48) (2018)
Huayun Shi, Isolda Romero-Canelon, Monika Hreusova, Olga Novakova, V Venkatesh, Abraha Habtemariam, Guy J Clarkson, Ji-Inn Song, Viktor Brabec, Peter J Sadler
Photoactivatable Cell-Selective Dinuclear trans-Diazidoplatinum(IV) Anticancer Prodrugs. Inorganic chemistry 57 (22) (2018)
Vojtech Novohradsky, Ilaria Zanellato, Cristina Marzano, Jitka Pracharova, Jana Kasparkova, Dan Gibson, Valentina Gandin, Domenico Osella, Viktor Brabec
Epigenetic and antitumor effects of platinum(IV)-octanoato conjugates. Scientific reports 7 (1) (2017)
Vojtech Novohradsky, Jyoti Yellol, Olga Stuchlikova, María Dolores Santana, Hana Kostrhunova, Gorakh Yellol, Jana Kasparkova, Delia Bautista, José Ruiz, Viktor Brabec
Organoruthenium Complexes with C^N Ligands are Highly Potent Cytotoxic Agents that Act by a New Mechanism of Action. Chemistry (Weinheim an der Bergstrasse, Germany) 23 (61) (2017)

Viktor Brabec.css-eqlu8i{font-size:small;padding-left:4px;} (V Brabec)

Publication Activity (10 Years)

Top Topics

Top Venues

Viktor Brabec (V Brabec)