Zhuo Huang

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 47

Top Topics

Molecular Dynamics Simulations

Transcranial Direct Current Stimulation

Structural Basis

Temporal Lobe Epilepsy

Top Venues

Nature communications

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Journal of medicinal chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Hui Yang, Mengqin Jing, Chao Tian, Bingxun Li, Weiming Liao, Wei Wang, Yunzhe Li, Xiaowei Wang, Guifang Duan, Qi Sun, Zhuo Huang, Lin Wu
1,4-Disubstituted Piperazin-2-Ones as Selective Late Sodium Current Inhibitors with QT Interval Shortening Properties in Isolated Rabbit Hearts. Journal of medicinal chemistry 67 (15) (2024)
Yifan Wang, Hui Yang, Na Li, Lili Wang, Chang Guo, Weining Ma, Shiqi Liu, Chao Peng, Jiexin Chen, Huifang Song, Hedan Chen, Xinyue Ma, Jingyun Yi, Jingjing Lian, Weikaixin Kong, Jie Dong, Xinyu Tu, Mala Shah, Xin Tian, Zhuo Huang
A Novel Ubiquitin Ligase Adaptor PTPRN Suppresses Seizure Susceptibility through Endocytosis of Na V 1.2 Sodium Channels. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11 (29) (2024)
Hui Yang, Mengqin Jing, Chao Tian, Bingxun Li, Weiming Liao, Wei Wang, Yunzhe Li, Xiaowei Wang, Guifang Duan, Qi Sun, Zhuo Huang, Lin Wu
1,4-Disubstituted Piperazin-2-Ones as Selective Late Sodium Current Inhibitors with QT Interval Shortening Properties in Isolated Rabbit Hearts. Journal of medicinal chemistry (2024)
Yiqing Wei, Zhuoya Yu, Lili Wang, Xiaojing Li, Na Li, Qinru Bai, Yuhang Wang, Renjie Li, Yufei Meng, Hao Xu, Xianping Wang, Yanli Dong, Zhuo Huang, Xuejun Cai Zhang, Yan Zhao
Structural bases of inhibitory mechanism of Ca V 1.2 channel inhibitors. Nature communications 15 (1) (2024)
Tian Yuan, Yifan Wang, Yuchen Jin, Hui Yang, Shuai Xu, Heng Zhang, Qian Chen, Na Li, Xinyue Ma, Huifang Song, Chao Peng, Ze Geng, Jie Dong, Guifang Duan, Qi Sun, Yang Yang, Fan Yang, Zhuo Huang
Coupling of Slack and Na V 1.6 sensitizes Slack to quinidine blockade and guides anti-seizure strategy development. eLife 12 (2024)
Tian Yuan, Yifan Wang, Yuchen Jin, Hui Yang, Shuai Xu, Heng Zhang, Qian Chen, Na Li, Xinyue Ma, Huifang Song, Chao Peng, Ze Geng, Jie Dong, Guifang Duan, Qi Sun, Yang Yang, Fan Yang, Zhuo Huang
Coupling of Slack and Na V 1.6 sensitizes Slack to quinidine blockade and guides anti-seizure strategy development. eLife 12 (2024)
Shirong Lai, Libo Zhang, Xinyu Tu, Xinyue Ma, Yujing Song, Kexin Cao, Miaomiao Li, Jihong Meng, Yiqiang Shi, Qing Wu, Chen Yang, Zifan Lan, Chun-Yue Geoffrey Lau, Jie Shi, Weining Ma, Shaoyi Li, Yan-Xue Xue, Zhuo Huang
Termination of convulsion seizures by destabilizing and perturbing seizure memory engrams. Science advances 10 (12) (2024)
Tian Yuan, Yifan Wang, Yuchen Jin, Hui Yang, Shuai Xu, Heng Zhang, Qian Chen, Na Li, Xinyue Ma, Huifang Song, Chao Peng, Ze Geng, Jie Dong, Guifang Duan, Qi Sun, Yang Yang, Fan Yang, Zhuo Huang
Coupling of Slack and Na V 1.6 sensitizes Slack to quinidine blockade and guides anti-seizure strategy development. eLife 12 (2024)
Yifan Wang, Hui Yang, Na Li, Lili Wang, Chang Guo, Weining Ma, Shiqi Liu, Chao Peng, Jiexin Chen, Huifang Song, Hedan Chen, Xinyue Ma, Jingyun Yi, Jingjing Lian, Weikaixin Kong, Jie Dong, Xinyu Tu, Mala Shah, Xin Tian, Zhuo Huang
A Novel Ubiquitin Ligase Adaptor PTPRN Suppresses Seizure Susceptibility through Endocytosis of Na V 1.2 Sodium Channels. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11 (29) (2024)
Tian Yuan, Yifan Wang, Yuchen Jin, Hui Yang, Shuai Xu, Heng Zhang, Qian Chen, Na Li, Xinyue Ma, Huifang Song, Chao Peng, Ze Geng, Jie Dong, Guifang Duan, Qi Sun, Yang Yang, Fan Yang, Zhuo Huang
Coupling of Slack and Na V 1.6 sensitizes Slack to quinidine blockade and guides anti-seizure strategy development. eLife 12 (2024)
Junping Fan, Chang Guo, Daohong Liao, Han Ke, Jing Lei, Wenjun Xie, Yuliang Tang, Makoto Tominaga, Zhuo Huang, Xiaoguang Lei
Structural Pharmacology of TRPV4 Antagonists. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11 (25) (2024)
Huiwen Chen, Zhanyi Xia, Jie Dong, Bo Huang, Jiangtao Zhang, Feng Zhou, Rui Yan, Yiqiang Shi, Jianke Gong, Juquan Jiang, Zhuo Huang, Daohua Jiang
Structural mechanism of voltage-gated sodium channel slow inactivation. Nature communications 15 (1) (2024)
Tian Yuan, Yifan Wang, Yuchen Jin, Hui Yang, Shuai Xu, Heng Zhang, Qian Chen, Na Li, Xinyue Ma, Huifang Song, Chao Peng, Ze Geng, Jie Dong, Guifang Duan, Qi Sun, Yang Yang, Fan Yang, Zhuo Huang
Coupling of Slack and Na V 1.6 sensitizes Slack to quinidine blockade and guides anti-seizure strategy development. eLife 12 (2024)
Huiwen Chen, Zhanyi Xia, Jie Dong, Bo Huang, Jiangtao Zhang, Feng Zhou, Rui Yan, Yiqiang Shi, Jianke Gong, Juquan Jiang, Zhuo Huang, Daohua Jiang
Structural mechanism of voltage-gated sodium channel slow inactivation. Nature communications 15 (1) (2024)
Yiqing Wei, Zhuoya Yu, Lili Wang, Xiaojing Li, Na Li, Qinru Bai, Yuhang Wang, Renjie Li, Yufei Meng, Hao Xu, Xianping Wang, Yanli Dong, Zhuo Huang, Xuejun Cai Zhang, Yan Zhao
Structural bases of inhibitory mechanism of Ca V 1.2 channel inhibitors. Nature communications 15 (1) (2024)
Junping Fan, Chang Guo, Daohong Liao, Han Ke, Jing Lei, Wenjun Xie, Yuliang Tang, Makoto Tominaga, Zhuo Huang, Xiaoguang Lei
Structural Pharmacology of TRPV4 Antagonists. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11 (25) (2024)
Yiqing Wei, Zhuoya Yu, Lili Wang, Xiaojing Li, Na Li, Qinru Bai, Yuhang Wang, Renjie Li, Yufei Meng, Hao Xu, Xianping Wang, Yanli Dong, Zhuo Huang, Xuejun Cai Zhang, Yan Zhao
Structural bases of inhibitory mechanism of Ca V 1.2 channel inhibitors. Nature communications 15 (1) (2024)
Pengliang Chi, Xiang Wang, Jialu Li, Hui Yang, Kaiju Li, Yuqi Zhang, Shiyi Lin, Leiye Yu, Shiqi Liu, Mei Chen, Ruobing Ren, Jianping Wu, Zhuo Huang, Jia Geng, Dong Deng
Molecular insights into the inhibition of proton-activated chloride channel by transfer RNA. Cell research (2024)
Shirong Lai, Libo Zhang, Xinyu Tu, Xinyue Ma, Yujing Song, Kexin Cao, Miaomiao Li, Jihong Meng, Yiqiang Shi, Qing Wu, Chen Yang, Zifan Lan, Chun-Yue Geoffrey Lau, Jie Shi, Weining Ma, Shaoyi Li, Yan-Xue Xue, Zhuo Huang
Termination of convulsion seizures by destabilizing and perturbing seizure memory engrams. Science advances 10 (12) (2024)
Yifan Wang, Hui Yang, Na Li, Lili Wang, Chang Guo, Weining Ma, Shiqi Liu, Chao Peng, Jiexin Chen, Huifang Song, Hedan Chen, Xinyue Ma, Jingyun Yi, Jingjing Lian, Weikaixin Kong, Jie Dong, Xinyu Tu, Mala Shah, Xin Tian, Zhuo Huang
A Novel Ubiquitin Ligase Adaptor PTPRN Suppresses Seizure Susceptibility through Endocytosis of Na V 1.2 Sodium Channels. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2024)
Huiwen Chen, Zhanyi Xia, Jie Dong, Bo Huang, Jiangtao Zhang, Feng Zhou, Rui Yan, Yiqiang Shi, Jianke Gong, Juquan Jiang, Zhuo Huang, Daohua Jiang
Structural mechanism of voltage-gated sodium channel slow inactivation. Nature communications 15 (1) (2024)
Hui Yang, Mengqin Jing, Chao Tian, Bingxun Li, Weiming Liao, Wei Wang, Yunzhe Li, Xiaowei Wang, Guifang Duan, Qi Sun, Zhuo Huang, Lin Wu
1,4-Disubstituted Piperazin-2-Ones as Selective Late Sodium Current Inhibitors with QT Interval Shortening Properties in Isolated Rabbit Hearts. Journal of medicinal chemistry 67 (15) (2024)
Yifan Wang, Hui Yang, Na Li, Lili Wang, Chang Guo, Weining Ma, Shiqi Liu, Chao Peng, Jiexin Chen, Huifang Song, Hedan Chen, Xinyue Ma, Jingyun Yi, Jingjing Lian, Weikaixin Kong, Jie Dong, Xinyu Tu, Mala Shah, Xin Tian, Zhuo Huang
A Novel Ubiquitin Ligase Adaptor PTPRN Suppresses Seizure Susceptibility through Endocytosis of Na V 1.2 Sodium Channels. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11 (29) (2024)
Tian Yuan, Yifan Wang, Yuchen Jin, Hui Yang, Shuai Xu, Heng Zhang, Qian Chen, Na Li, Xinyue Ma, Huifang Song, Chao Peng, Ze Geng, Jie Dong, Guifang Duan, Qi Sun, Yang Yang, Fan Yang, Zhuo Huang
Coupling of Slack and Na V 1.6 sensitizes Slack to quinidine blockade and guides anti-seizure strategy development. eLife 12 (2024)
Shirong Lai, Libo Zhang, Xinyu Tu, Xinyue Ma, Yujing Song, Kexin Cao, Miaomiao Li, Jihong Meng, Yiqiang Shi, Qing Wu, Chen Yang, Zifan Lan, Chun-Yue Geoffrey Lau, Jie Shi, Weining Ma, Shaoyi Li, Yan-Xue Xue, Zhuo Huang
Termination of convulsion seizures by destabilizing and perturbing seizure memory engrams. Science advances 10 (12) (2024)
Junping Fan, Chang Guo, Daohong Liao, Han Ke, Jing Lei, Wenjun Xie, Yuliang Tang, Makoto Tominaga, Zhuo Huang, Xiaoguang Lei
Structural Pharmacology of TRPV4 Antagonists. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11 (25) (2024)
Junping Fan, Chang Guo, Daohong Liao, Han Ke, Jing Lei, Wenjun Xie, Yuliang Tang, Makoto Tominaga, Zhuo Huang, Xiaoguang Lei
Structural Pharmacology of TRPV4 Antagonists. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2024)
Yue Li, Tian Yuan, Bo Huang, Feng Zhou, Chao Peng, Xiaojing Li, Yunlong Qiu, Bei Yang, Yan Zhao, Zhuo Huang, Daohua Jiang
Structure of human Na V 1.6 channel reveals Na + selectivity and pore blockade by 4,9-anhydro-tetrodotoxin. Nature communications 14 (1) (2023)
Yiwei Gao, Shuai Xu, Xiaoli Cui, Hao Xu, Yunlong Qiu, Yiqing Wei, Yanli Dong, Boling Zhu, Chao Peng, Shiqi Liu, Xuejun Cai Zhang, Jianyuan Sun, Zhuo Huang, Yan Zhao
Molecular insights into the gating mechanisms of voltage-gated calcium channel Ca V 2.3. Nature communications 14 (1) (2023)
Yiwei Gao, Shuai Xu, Xiaoli Cui, Hao Xu, Yunlong Qiu, Yiqing Wei, Yanli Dong, Boling Zhu, Chao Peng, Shiqi Liu, Xuejun Cai Zhang, Jianyuan Sun, Zhuo Huang, Yan Zhao
Molecular insights into the gating mechanisms of voltage-gated calcium channel Ca V 2.3. Nature communications 14 (1) (2023)
Yiwei Gao, Shuai Xu, Xiaoli Cui, Hao Xu, Yunlong Qiu, Yiqing Wei, Yanli Dong, Boling Zhu, Chao Peng, Shiqi Liu, Xuejun Cai Zhang, Jianyuan Sun, Zhuo Huang, Yan Zhao
Molecular insights into the gating mechanisms of voltage-gated calcium channel Ca V 2.3. Nature communications 14 (1) (2023)
Yue Li, Tian Yuan, Bo Huang, Feng Zhou, Chao Peng, Xiaojing Li, Yunlong Qiu, Bei Yang, Yan Zhao, Zhuo Huang, Daohua Jiang
Structure of human Na V 1.6 channel reveals Na + selectivity and pore blockade by 4,9-anhydro-tetrodotoxin. Nature communications 14 (1) (2023)
Yiwei Gao, Shuai Xu, Xiaoli Cui, Hao Xu, Yunlong Qiu, Yiqing Wei, Yanli Dong, Boling Zhu, Chao Peng, Shiqi Liu, Xuejun Cai Zhang, Jianyuan Sun, Zhuo Huang, Yan Zhao
Molecular insights into the gating mechanisms of voltage-gated calcium channel Ca V 2.3. Nature communications 14 (1) (2023)
Yiwei Gao, Shuai Xu, Xiaoli Cui, Hao Xu, Yunlong Qiu, Yiqing Wei, Yanli Dong, Boling Zhu, Chao Peng, Shiqi Liu, Xuejun Cai Zhang, Jianyuan Sun, Zhuo Huang, Yan Zhao
Molecular insights into the gating mechanisms of voltage-gated calcium channel Ca V 2.3. Nature communications 14 (1) (2023)
Yue Li, Tian Yuan, Bo Huang, Feng Zhou, Chao Peng, Xiaojing Li, Yunlong Qiu, Bei Yang, Yan Zhao, Zhuo Huang, Daohua Jiang
Structure of human Na V 1.6 channel reveals Na + selectivity and pore blockade by 4,9-anhydro-tetrodotoxin. Nature communications 14 (1) (2023)
Yue Li, Tian Yuan, Bo Huang, Feng Zhou, Chao Peng, Xiaojing Li, Yunlong Qiu, Bei Yang, Yan Zhao, Zhuo Huang, Daohua Jiang
Structure of human Na V 1.6 channel reveals Na + selectivity and pore blockade by 4,9-anhydro-tetrodotoxin. Nature communications 14 (1) (2023)
Yue Li, Tian Yuan, Bo Huang, Feng Zhou, Chao Peng, Xiaojing Li, Yunlong Qiu, Bei Yang, Yan Zhao, Zhuo Huang, Daohua Jiang
Structure of human Na V 1.6 channel reveals Na + selectivity and pore blockade by 4,9-anhydro-tetrodotoxin. Nature communications 14 (1) (2023)
Yue Li, Tian Yuan, Bo Huang, Feng Zhou, Chao Peng, Xiaojing Li, Yunlong Qiu, Bei Yang, Yan Zhao, Zhuo Huang, Daohua Jiang
Structure of human Na V 1.6 channel reveals Na + selectivity and pore blockade by 4,9-anhydro-tetrodotoxin. Nature communications 14 (1) (2023)
Lingli He, Zhuoya Yu, Ze Geng, Zhuo Huang, Changjiang Zhang, Yanli Dong, Yiwei Gao, Yuhang Wang, Qihao Chen, Le Sun, Xinyue Ma, Bo Huang, Xiaoqun Wang, Yan Zhao
Structure, gating, and pharmacology of human Ca V 3.3 channel. Nature communications 13 (1) (2022)
Zhenglai Zhang, Huiwen Chen, Ze Geng, Zhuoya Yu, Hang Li, Yanli Dong, Hongwei Zhang, Zhuo Huang, Juquan Jiang, Yan Zhao
Structural basis of ligand binding modes of human EAAT2. Nature communications 13 (1) (2022)
Jiangtao Zhang, Yiqiang Shi, Junping Fan, Huiwen Chen, Zhanyi Xia, Bo Huang, Juquan Jiang, Jianke Gong, Zhuo Huang, Daohua Jiang
N-type fast inactivation of a eukaryotic voltage-gated sodium channel. Nature communications 13 (1) (2022)
Jiangtao Zhang, Yiqiang Shi, Zhuo Huang, Yue Li, Bei Yang, Jianke Gong, Daohua Jiang
Structural basis for Na V 1.7 inhibition by pore blockers. Nature structural & molecular biology (2022)
Jie Zhu, Jingxiang Wang, Xin Wang, Mingjing Gao, Bingbing Guo, Miaomiao Gao, Jiarui Liu, Yanqiu Yu, Liang Wang, Weikaixin Kong, Yongpan An, Zurui Liu, Xinpei Sun, Zhuo Huang, Hong Zhou, Ning Zhang, Ruimao Zheng, Zhengwei Xie
Prediction of drug efficacy from transcriptional profiles with deep learning. Nature biotechnology 39 (11) (2021)
Zhongtang Li, Guanxing Cai, Fan Fang, Wenchao Li, Minghua Fan, Jingjing Lian, Yinli Qiu, Xiangqing Xu, Xuehui Lv, Yiyan Li, Ruqiu Zheng, Yuxi Wang, Zhong-Jun Li, Guisen Zhang, Zhen-Ming Liu, Zhuo Huang, Liangren Zhang
Discovery of Novel and Potent N-Methyl-d-aspartate Receptor Positive Allosteric Modulators with Antidepressant-like Activity in Rodent Models. Journal of medicinal chemistry 64 (9) (2021)
Weikaixin Kong, Xinyu Tu, Weiran Huang, Yang Yang, Zhengwei Xie, Zhuo Huang
Prediction and Optimization of NaV1.7 Sodium Channel Inhibitors Based on Machine Learning and Simulated Annealing. Journal of chemical information and modeling 60 (6) (2020)
Xueqin Jin, Qian Chen, Yan Song, Jie Zheng, Kuo Xiao, Shan Shao, Zibing Fu, Ming Yi, Yang Yang, Zhuo Huang
Dopamine D2 receptors regulate the action potential threshold by modulating T-type calcium channels in stellate cells of the medial entorhinal cortex. The Journal of physiology 597 (13) (2019)
Kuo Xiao, Zhiming Sun, Xueqin Jin, Weining Ma, Yan Song, Shirong Lai, Qian Chen, Minghua Fan, Jingliang Zhang, Weihua Yue, Zhuo Huang
ERG3 potassium channel-mediated suppression of neuronal intrinsic excitability and prevention of seizure generation in mice. The Journal of physiology 596 (19) (2018)