Longitudinal changes of spinal cord grey and white matter following spinal cord injury.
Gergely DavidDario PfyfferKevin VallottonNikolai PfenderAlan ThompsonNikolaus WeiskopfSiawoosh MohammadiArmin CurtPatrick FreundPublished in: Journal of neurology, neurosurgery, and psychiatry (2021)
This study describes the spatiotemporal dynamics of tissue-specific spinal cord neurodegeneration above and below a spinal cord injury. While above the injury, grey matter atrophy lagged initially behind white matter neurodegeneration, in the lumbar enlargement these processes progressed in parallel. Tracking trajectories of tissue-specific neurodegeneration provides valuable assessment tools for monitoring recovery and treatment effects.