A phase 2 study of valproic acid and radiation, followed by maintenance valproic acid and bevacizumab in children with newly diagnosed diffuse intrinsic pontine glioma or high-grade glioma.

Jack Meng-Fen SuJeffrey C MurrayRene Y McNall-KnappDaniel C BowersShafqat ShahAdekunle M AdesinaArnold C PaulinoEunji JoQianxing MoPatricia A BaxterSusan M Blaney

Published in: Pediatric blood & cancer (2020)

Addition of VPA and bevacizumab to radiation was well tolerated but did not appear to improve EFS or OS in children with DIPG or HGG.

Keyphrases

high grade
newly diagnosed
young adults
low grade
metastatic colorectal cancer
radiation induced
randomized controlled trial
radiation therapy
double blind
placebo controlled