Tuberculosis treatment outcomes in a rural area of Senegal: a decade of experience from 2010 to 2019 by StopTB Italia.
Niccolò RiccardiSimone VillaAndrea GiacomelliMama M DiawMamoud NdiayeLamine GningMarta RobbianoRiccardo AlagnaLaura SaderiAntonio Di BiagioMatteo BassettiDaniela M CirilloGiovanni SotgiuLuigi Ruffo CodecasaMarie SarrGiorgio BesozziPublished in: Future microbiology (2021)
Background: Tuberculosis (TB) unevenly affects individuals across the globe, especially in rural areas of low-income countries. Aim of the study was to assess the impact of social protection to increase TB awareness on treatment outcomes among TB patients in a rural area of Senegal. Materials & methods: The study, conducted in Fimela district (Senegal) from 1 January 2010 to 31 December 2019 and the intervention started from 31 January 2013, includes activities to increase awareness, active case finding, active follow-up and social protection. Results: Overall, 435 subjects - mainly male and young - were included in the analysis. Among TB cases, 94% had pulmonary involvement, 87% had no previous TB history, and 6% resulted positive HIV. Improved outcome was observed once intervention began (from 71 to 91%, p < 0.001); whereas mortality decreased (from 15 to 5%; p < 0.001), especially for those HIV co-infected for whom TB mortality rate dropped from 70 to 29%. Conclusion: After beginning the cooperation program, TB treatment success increased as a result of the decline of mortality, especially in people living with HIV.
Keyphrases
- mycobacterium tuberculosis
- south africa
- randomized controlled trial
- hiv aids
- pulmonary tuberculosis
- antiretroviral therapy
- hiv positive
- cardiovascular events
- healthcare
- human immunodeficiency virus
- hiv infected
- hepatitis c virus
- mental health
- risk factors
- hiv testing
- prognostic factors
- type diabetes
- coronary artery disease
- adverse drug