Three-dimensional histology reveals dissociable human hippocampal long axis gradients of Alzheimer's pathology.
Diana Ortega-CruzKimberly S BressHarshvardhan GazulaAlberto RabanoJuan Eugenio IglesiasBryan A StrangePublished in: bioRxiv : the preprint server for biology (2023)
Path2MR, which enables 3D histology using any brain bank dataset, revealed significant differences along the hippocampus between tau and amyloid-β.
Keyphrases
- cerebral ischemia
- endothelial cells
- induced pluripotent stem cells
- white matter
- cognitive decline
- resting state
- magnetic resonance
- pluripotent stem cells
- single cell
- blood brain barrier
- brain injury
- contrast enhanced
- magnetic resonance imaging
- computed tomography
- cognitive impairment
- prefrontal cortex
- mild cognitive impairment