Association between vertebral endplate defects and patient-reported symptoms: an immunohistochemical study investigating the COX-2/PGE-2/EP-4 axis.

Haojie ChenQingshuang ZhouXiaojiang PuNannan WangSinian WangZhenhua FengBin WangZezhang ZhuYong QiuXu Sun

Published in: The spine journal : official journal of the North American Spine Society (2024)

Patients with endplate defects had worse quality of life, more severe disc degeneration and Modic changes, and up-regulated COX-2/PGE-2/EP-4 axis expression in cartilage endplates in patients with defected endplates. Inflammatory factors may significantly contribute to the onset and progression of chronic low back pain in patients with endplate defects, consequently impacting patient-reported symptoms.

Keyphrases

patient reported
poor prognosis
sleep quality
oxidative stress
early onset
bone mineral density
physical activity
depressive symptoms
body composition
drug induced