Analysis of single nuclear chromatin accessibility reveals unique myeloid populations in human pancreatic ductal adenocarcinoma.

Hillary G PrattLi MaSebastian A DziadowiczSascha OttThomas WhalleyBarbara SzomolayTimothy D EubankGangqing HuBrian A Boone

Published in: Clinical and translational medicine (2024)

These data suggest snATAC-Seq as a method for analysis of frozen human pancreatic tissues to distinguish myeloid populations. An improved understanding of myeloid cell heterogeneity and function is important for developing new treatment targets in PDAC.

Keyphrases

endothelial cells
single cell
dendritic cells
bone marrow
acute myeloid leukemia
gene expression
induced pluripotent stem cells
genome wide
pluripotent stem cells
rna seq
dna damage
transcription factor
immune response
electronic health record
mesenchymal stem cells
cell therapy