Postexposure Prophylaxis and Treatment of Bacillus anthracis Infections: A Systematic Review and Meta-analyses of Animal Models, 1947-2019.

Jordan L KennedyJürgen B BulittaKevin Chatham-StephensMarissa K PersonRachel CookThitipong MongkolrattanothaiEunjeong ShinPatricia YuMaria E NegronWilliam A BowerKatherine Hendricks

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)

These animal studies show many reviewed antimicrobials are good choices for PEPAbx or treatment of susceptible B. anthracis strains, and some are also promising options for combating resistant strains. Monte Carlo simulations suggest that oral ciprofloxacin, levofloxacin, and doxycycline are particularly robust choices for PEPAbx or treatment.

Keyphrases

escherichia coli
systematic review
randomized controlled trial
meta analyses
combination therapy
cystic fibrosis
molecular dynamics
bacillus subtilis