Axonal Excitability Does Not Differ between Painful and Painless Diabetic or Chemotherapy-Induced Distal Symmetrical Polyneuropathy in a Multicenter Observational Study.
Andreas C ThemistocleousAlexander G KristensenRoma SolaSandra S GylfadottirKristine BennedsgaardMustapha ItaniThomas KrøigårdLise VentzelSøren H SindrupTroels S JensenHugh BostockJordi SerraNanna B FinnerupHatice TankisiDavid L H BennettPublished in: Annals of neurology (2022)
Axonal excitability did not significantly differ between painful and painless diabetic or chemotherapy-induced polyneuropathy in a multicenter observational study. Threshold tracking assesses the excitability of myelinated axons; the majority of nociceptors are unmyelinated, and although there is some overlap of the "channelome" between these axonal populations, our results suggest that alternative measures such as microneurography are required to understand the relationship between sensory neuron excitability and neuropathic pain. ANN NEUROL 2022;91:506-520.