Outcomes from an inpatient beta-lactam allergy guideline across a large US health system.
Kimberly G BlumenthalYu LiJoyce T HsuAnna R WolfsonDavid N BerkowitzVictoria A CarballoJesse M SchwartzKathleen A MarquisRamy ElshabouryRonak G GandhiBarbara B LamblMonique M FreeleyAlana GruszeckiPaige G WicknerErica S ShenoyPublished in: Infection control and hospital epidemiology (2019)
This antimicrobial stewardship intervention using β-lactam test-dose procedures was safe. Overall, 3.8% of patients with β-lactam allergy histories had an HSR; cephalosporin allergy histories conferred a 3-fold increased risk. Encouraging EHR documentation might improve this safe, effective, and practical acute-care antibiotic stewardship tool.