CHSY1 promotes CD8 + T cell exhaustion through activation of succinate metabolism pathway leading to colorectal cancer liver metastasis based on CRISPR/Cas9 screening.
Guangshun SunSiqi ZhaoZhongguo FanYuliang WangHanyuan LiuHengsong CaoGuoqiang SunTian HuangHongzhou CaiHong PanDawei RongYun GaoWeiwei TangPublished in: Journal of experimental & clinical cancer research : CR (2023)
T cell exhaustion through activation of the succinate metabolic and PI3K/AKT/HIF1A pathway, leading to CRC liver metastasis. The combination of CHSY1 knockdown and anti-PD1 contributes to synergistic resistance to CRC liver metastasis. Artemisinin significantly inhibits CHSY1 activity and in combination with anti-PD1 could synergistically treat CRC liver metastases. This study provides new targets and specific strategies for the treatment of CRC liver metastases, bringing new hope and benefits to patients.
Keyphrases
- liver metastases
- pi k akt
- crispr cas
- signaling pathway
- end stage renal disease
- cell proliferation
- newly diagnosed
- ejection fraction
- chronic kidney disease
- genome editing
- cell cycle arrest
- prognostic factors
- patient reported outcomes
- cell death
- drug delivery
- plasmodium falciparum
- replacement therapy
- smoking cessation