The optimal management of brain metastases from gestational trophoblastic neoplasia.
Joseph TsaiBalamurugan A VellayappanVyshak VenurTresa McGranahanHeidi GrayRenata R UrbanYolanda D TsengJoshua PalmerMatthew FooteNina A MayrStephanie Elisabeth CombsArjun SahgalEric L ChangSimon S LoPublished in: Expert review of anticancer therapy (2022)
Systemic therapy is the frontline treatment for GTN with brain metastases, and radiotherapy should only be considered in the context of a clinical trial or for resistant/recurrent disease. Surgery has a limited role in palliating symptoms or relieving intracranial pressure/bleeding. Given the highly specialized care these patients require, treatment at a high-volume referral center with multidisciplinary collaboration likely leads to better outcomes. Randomized trials should be conducted to determine the best systemic therapy option for GTN.
Keyphrases
- brain metastases
- small cell lung cancer
- clinical trial
- healthcare
- end stage renal disease
- palliative care
- newly diagnosed
- minimally invasive
- radiation therapy
- high grade
- chronic kidney disease
- pregnant women
- weight gain
- randomized controlled trial
- prognostic factors
- body mass index
- atrial fibrillation
- coronary artery disease
- skeletal muscle
- radiation induced
- acute coronary syndrome
- bone marrow
- patient reported outcomes
- drug induced
- weight loss
- replacement therapy
- rectal cancer
- birth weight
- phase iii