β2-Microglobulin Maintains Glioblastoma Stem Cells and Induces M2-like Polarization of Tumor-Associated Macrophages.

Daqi LiQian ZhangLu LiKexin ChenJunlei YangDeobrat Dixit Ryan N GimpleShusheng CiChenfei LuLang HuJiancheng GaoDanyang ShanYangqing LiJunxia ZhangZhumei ShiDanling GuWei YuanQiulian WuKailin YangLinjie ZhaoZhixin QiuDeguang LvWei GaoHui YangFan LinQiang-Hu Wang Jianghong ManChaojun LiWeiwei TaoSameer AgnihotriXu QianYu ShiYongping YouNu Zhang Jeremy N Rich Xiuxing Wang

Published in: Cancer research (2022)

β2-microglobulin signaling in glioblastoma cells activates a PI3K/AKT/MYC/TGFβ1 axis that maintains stem cells and induces M2-like macrophage polarization, highlighting potential therapeutic strategies for targeting tumor cells and the immunosuppressive microenvironment in glioblastoma.

Keyphrases

stem cells
pi k akt
cell cycle arrest
signaling pathway
induced apoptosis
cell death
cell proliferation
cell therapy
transcription factor
transforming growth factor
oxidative stress
endoplasmic reticulum stress