Ryan N Gimple (Ryan C Gimple)

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 22

Top Topics

Histone Deacetylase

Vascular Endothelial Growth Factor

Top Venues

Cancer discovery

Cancer research

Science translational medicine

This page only lists publications with an associated author ORCID identifier.

Publications

Linjie Zhao, Zhixin Qiu, Zhengnan Yang, Lian Xu, Thomas M Pearce, Qiulian Wu, Kailin Yang, FuLong Li, Olivier Saulnier, Fan Fei, Huaxu Yu, Ryan N Gimple, Venkateshwari Varadharajan, Juxiu Liu, Liam D Hendrikse, Vernon Fong, Wei Wang, Jiao Zhang, Deguan Lv, Derrick Lee, Brandon M Lehrich, Chunyu Jin, Liang Ouyang, Deobrat Dixit, Haoxing Wu, Xiang Wang, Andrew E Sloan, Xiuxing Wang, Tao Huan, Jonathan Mark Brown, Steven A Goldman, Michael D Taylor, Shengtao Zhou, Jeremy N Rich
Lymphatic endothelial-like cells promote glioblastoma stem cell growth through cytokine-driven cholesterol metabolism. Nature cancer 5 (1) (2024)
Linjie Zhao, Zhixin Qiu, Zhengnan Yang, Lian Xu, Thomas M Pearce, Qiulian Wu, Kailin Yang, FuLong Li, Olivier Saulnier, Fan Fei, Huaxu Yu, Ryan N Gimple, Venkateshwari Varadharajan, Juxiu Liu, Liam D Hendrikse, Vernon Fong, Wei Wang, Jiao Zhang, Deguan Lv, Derrick Lee, Brandon M Lehrich, Chunyu Jin, Liang Ouyang, Deobrat Dixit, Haoxing Wu, Xiang Wang, Andrew E Sloan, Xiuxing Wang, Tao Huan, Jonathan Mark Brown, Steven A Goldman, Michael D Taylor, Shengtao Zhou, Jeremy N Rich
Lymphatic endothelial-like cells promote glioblastoma stem cell growth through cytokine-driven cholesterol metabolism. Nature cancer 5 (1) (2024)
Linjie Zhao, Zhixin Qiu, Zhengnan Yang, Lian Xu, Thomas M Pearce, Qiulian Wu, Kailin Yang, FuLong Li, Olivier Saulnier, Fan Fei, Huaxu Yu, Ryan N Gimple, Venkateshwari Varadharajan, Juxiu Liu, Liam D Hendrikse, Vernon Fong, Wei Wang, Jiao Zhang, Deguan Lv, Derrick Lee, Brandon M Lehrich, Chunyu Jin, Liang Ouyang, Deobrat Dixit, Haoxing Wu, Xiang Wang, Andrew E Sloan, Xiuxing Wang, Tao Huan, Jonathan Mark Brown, Steven A Goldman, Michael D Taylor, Shengtao Zhou, Jeremy N Rich
Lymphatic endothelial-like cells promote glioblastoma stem cell growth through cytokine-driven cholesterol metabolism. Nature cancer 5 (1) (2024)
Linjie Zhao, Zhixin Qiu, Zhengnan Yang, Lian Xu, Thomas M Pearce, Qiulian Wu, Kailin Yang, FuLong Li, Olivier Saulnier, Fan Fei, Huaxu Yu, Ryan N Gimple, Venkateshwari Varadharajan, Juxiu Liu, Liam D Hendrikse, Vernon Fong, Wei Wang, Jiao Zhang, Deguan Lv, Derrick Lee, Brandon M Lehrich, Chunyu Jin, Liang Ouyang, Deobrat Dixit, Haoxing Wu, Xiang Wang, Andrew E Sloan, Xiuxing Wang, Tao Huan, Jonathan Mark Brown, Steven A Goldman, Michael D Taylor, Shengtao Zhou, Jeremy N Rich
Lymphatic endothelial-like cells promote glioblastoma stem cell growth through cytokine-driven cholesterol metabolism. Nature cancer 5 (1) (2024)
Linjie Zhao, Zhixin Qiu, Zhengnan Yang, Lian Xu, Thomas M Pearce, Qiulian Wu, Kailin Yang, FuLong Li, Olivier Saulnier, Fan Fei, Huaxu Yu, Ryan N Gimple, Venkateshwari Varadharajan, Juxiu Liu, Liam D Hendrikse, Vernon Fong, Wei Wang, Jiao Zhang, Deguan Lv, Derrick Lee, Brandon M Lehrich, Chunyu Jin, Liang Ouyang, Deobrat Dixit, Haoxing Wu, Xiang Wang, Andrew E Sloan, Xiuxing Wang, Tao Huan, Jonathan Mark Brown, Steven A Goldman, Michael D Taylor, Shengtao Zhou, Jeremy N Rich
Lymphatic endothelial-like cells promote glioblastoma stem cell growth through cytokine-driven cholesterol metabolism. Nature cancer (2024)
Zengpanpan Ye, Xiaolin Ai, Kailin Yang, Zhengnan Yang, Fan Fei, Xiaoling Liao, Zhixin Qiu, Ryan N Gimple, Huairui Yuan, Hao Huang, Yanqiu Gong, Chaoxin Xiao, Jing Yue, Liang Huang, Olivier Saulnier, Wei Wang, Peidong Zhang, Lunzhi Dai, Xin Wang, Xiuxing Wang, Young Ha Ahn, Chao You, Jian-Guo Xu, Xiaoxiao Wan, Michael D Taylor, Linjie Zhao, Jeremy N Rich, Shengtao Zhou
Targeting Microglial Metabolic Rewiring Synergizes with Immune Checkpoint Blockade Therapy for Glioblastoma. Cancer discovery (2023)
Lihui Liu, Ziyang Liu, Qinghua Liu, Wei Wu, Peng Lin, Xing Liu, Yuechuan Zhang, Dongpeng Wang, Briana C Prager, Ryan N Gimple, Jichuan Yu, Weixi Zhao, Qiulian Wu, Wei Zhang, Erzhong Wu, Xiaomin Chen, Jianjun Luo, Jeremy N Rich, Qi Xie, Tao Jiang, Runsheng Chen
LncRNA INHEG promotes glioma stem cell maintenance and tumorigenicity through regulating rRNA 2'-O-methylation. Nature communications 14 (1) (2023)
Zengpanpan Ye, Xiaolin Ai, Kailin Yang, Zhengnan Yang, Fan Fei, Xiaoling Liao, Zhixin Qiu, Ryan N Gimple, Huairui Yuan, Hao Huang, Yanqiu Gong, Chaoxin Xiao, Jing Yue, Liang Huang, Olivier Saulnier, Wei Wang, Peidong Zhang, Lunzhi Dai, Xin Wang, Xiuxing Wang, Young Ha Ahn, Chao You, Jian-Guo Xu, Xiaoxiao Wan, Michael D Taylor, Linjie Zhao, Jeremy N Rich, Shengtao Zhou
Targeting Microglial Metabolic Rewiring Synergizes with Immune Checkpoint Blockade Therapy for Glioblastoma. Cancer discovery (2023)
Wei Yuan, Qian Zhang, Danling Gu, Chenfei Lu, Deobrat Dixit, Ryan N Gimple, Yisu Gao, Jiancheng Gao, Daqi Li, Danyan Shan, Lang Hu, Lu Li, Yangqing Li, Shusheng Ci, Hao You, Linping Yan, Kexin Chen, Ningwei Zhao, Chuanhai Xu, Jianyun Lan, Dong Liu, Junxia Zhang, Zhumei Shi, Qiulian Wu, Kailin Yang, Linjie Zhao, Zhixin Qiu, Deguan Lv, Wei Gao, Hui Yang, Fan Lin, Qiang-Hu Wang, Jianghong Man, Chao-Jun Li, Weiwei Tao, Sameer Agnihotri, Xu Qian, Stephen C Mack, Nu Zhang, Yongping You, Jeremy N Rich, Guan Sun, Xiuxing Wang
Dual role of CXCL8 in maintaining the mesenchymal state of glioblastoma stem cells and M2-like tumor-associated macrophages. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Daqi Li, Qian Zhang, Lu Li, Kexin Chen, Junlei Yang, Deobrat Dixit, Ryan N Gimple, Shusheng Ci, Chenfei Lu, Lang Hu, Jiancheng Gao, Danyang Shan, Yangqing Li, Junxia Zhang, Zhumei Shi, Danling Gu, Wei Yuan, Qiulian Wu, Kailin Yang, Linjie Zhao, Zhixin Qiu, Deguang Lv, Wei Gao, Hui Yang, Fan Lin, Qiang-Hu Wang, Jianghong Man, Chaojun Li, Weiwei Tao, Sameer Agnihotri, Xu Qian, Yu Shi, Yongping You, Nu Zhang, Jeremy N Rich, Xiuxing Wang
β2-Microglobulin Maintains Glioblastoma Stem Cells and Induces M2-like Polarization of Tumor-Associated Macrophages. Cancer research 82 (18) (2022)
Ryan N Gimple, Kailin Yang, Matthew E Halbert, Sameer Agnihotri, Jeremy N Rich
Brain cancer stem cells: resilience through adaptive plasticity and hierarchical heterogeneity. Nature reviews. Cancer 22 (9) (2022)
Deobrat Dixit, Briana C Prager, Ryan N Gimple, Tyler E Miller, Qiulian Wu, Shira Yomtoubian, Reilly L Kidwell, Deguan Lv, Linjie Zhao, Zhixin Qiu, Guoxing Zhang, Derrick Lee, Donglim Esther Park, Robert J Wechsler-Reya, Xiuxing Wang, Shideng Bao, Jeremy N Rich
Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases. Science translational medicine 14 (626) (2022)
Zhengnan Yang, Wei Wang, Linjie Zhao, Xin Wang, Ryan N Gimple, Lian Xu, Zhongwang Wang, Jeremy N Rich, Shengtao Zhou
Plasma cells shape the mesenchymal identity of ovarian cancers through transfer of exosome-derived microRNAs. Science advances 7 (9) (2021)
Arko Sen, Briana C Prager, Cuiqing Zhong, Donglim Park, Zhe Zhu, Ryan N Gimple, Qiulian Wu, Jean A Bernatchez, Sungjun Beck, Alex E Clark, Jair L Siqueira-Neto, Jeremy N Rich, Graham McVicker
Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma. Cancer research 82 (3) (2021)
Guoxing Zhang, Zhen Dong, Ryan N Gimple, Arthur Wolin, Qiulian Wu, Zhixin Qiu, Lisa M Wood, Jia Z Shen, Li Jiang, Linjie Zhao, Deguan Lv, Briana C Prager, Leo J Y Kim, Xiuxing Wang, Lingdi Zhang, Ryan L Anderson, Jeffrey K Moore, Shideng Bao, Thomas H Keller, Grace Lin, CongBao Kang, Petra Hamerlik, Rui Zhao, Heide L Ford, Jeremy N Rich
Targeting EYA2 tyrosine phosphatase activity in glioblastoma stem cells induces mitotic catastrophe. The Journal of experimental medicine 218 (11) (2021)
Zhixin Qiu, Linjie Zhao, Jia Z Shen, Zhengyu Liang, Qiulian Wu, Kailin Yang, Lihua Min, Ryan N Gimple, Qiyuan Yang, Shruti Bhargava, Chunyu Jin, Cheryl Kim, Denise Hinz, Deobrat Dixit, Jean A Bernatchez, Briana C Prager, Guoxin Zhang, Zhen Dong, Deguan Lv, Xujun Wang, Leo J Y Kim, Zhe Zhu, Katherine A Jones, Ye Zheng, Xiuxing Wang, Jair L Siqueira-Neto, Lukas Chavez, Xiang-Dong Fu, Charles Spruck, Jeremy N Rich
Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells. Cancer discovery (2021)
Xiuxing Wang, Kailin Yang, Qiulian Wu, Leo J Y Kim, Andrew R Morton, Ryan N Gimple, Briana C Prager, Yu Shi, Wenchao Zhou, Shruti Bhargava, Zhe Zhu, Li Jiang, Weiwei Tao, Zhixin Qiu, Linjie Zhao, Guoxing Zhang, Xiqing Li, Sameer Agnihotri, Paul S Mischel, Stephen C Mack, Shideng Bao, Jeremy N Rich
Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells. Science translational medicine 11 (504) (2020)
Briana C Prager, Harish N Vasudevan, Deobrat Dixit, Jean A Bernatchez, Qiulian Wu, Lisa C Wallace, Shruti Bhargava, Derrick Lee, Bradley H King, Andrew R Morton, Ryan N Gimple, Melike Pekmezci, Zhe Zhu, Jair L Siqueira-Neto, Xiuxing Wang, Qi Xie, Clark Chen, Gene H Barnett, Michael A Vogelbaum, Stephen C Mack, Lukas Chavez, Arie Perry, David R Raleigh, Jeremy N Rich
The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies. Cancer discovery 10 (11) (2020)
Deobrat Dixit, Briana C Prager, Ryan N Gimple, Hui Xian Poh, Xiuxing Wang, Qiulian Wu, Zhixin Qiu, Reilly L Kidwell, Leo J Y Kim, Qi Xie, Kristoffer Vitting-Seerup, Shruti Bhargava, Zhen Dong, Li Jiang, Zhe Zhu, Petra Hamerlik, Samie R Jaffrey, Jing Crystal Zhao, Jeremy N Rich
The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells. Cancer discovery 11 (2) (2020)
Dongrui Wang, Briana C Prager, Ryan N Gimple, Brenda Aguilar, Darya Alizadeh, Hongzhen Tang, Deguan Lv, Renate Starr, Alfonso Brito, Qiulian Wu, Leo J Y Kim, Zhixin Qiu, Peng Lin, Michael H Lorenzini, Behnam Badie, Stephen J Forman, Qi Xie, Christine E Brown, Jeremy N Rich
CRISPR Screening of CAR T Cells and Cancer Stem Cells Reveals Critical Dependencies for Cell-Based Therapies. Cancer discovery 11 (5) (2020)
Ryan N Gimple, Reilly L Kidwell, Leo J Y Kim, Tengqian Sun, Anthony D Gromovsky, Qiulian Wu, Megan Wolf, Deguan Lv, Shruti Bhargava, Li Jiang, Briana C Prager, Xiuxing Wang, Qing Ye, Zhe Zhu, Guoxin Zhang, Zhen Dong, Linjie Zhao, Derrick Lee, Junfeng Bi, Andrew E Sloan, Paul S Mischel, J Mark Brown, Hu Cang, Tao Huan, Stephen C Mack, Qi Xie, Jeremy N Rich
Glioma Stem Cell-Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling. Cancer discovery 9 (9) (2019)
Dan Su, Xuting Wang, Michelle R Campbell, Devin K Porter, Gary S Pittman, Brian D Bennett, Ma Wan, Neal A Englert, Christopher L Crowl, Ryan N Gimple, Kelly N Adamski, Zhiqing Huang, Susan K Murphy, Douglas A Bell
Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes. PloS one 11 (12) (2016)