Intrathecal Infusion of Autologous Adipose-Derived Regenerative Cells in Autoimmune Refractory Epilepsy: Evaluation of Safety and Efficacy.
Elzbieta SzczepanikHanna MierzewskaDorota Antczak-MarachAnna Figiel-DabrowskaIwona TerczynskaJolanta TryfonNatalia KrzesniakBartlomiej Henryk NoszczykEwa SawickaKrystyna Domanska-JanikAnna SarnowskaPublished in: Stem cells international (2020)
Autologous ADRC therapy may emerge as a promising option for some patients with autoimmune refractory epilepsy. Based on our trial and other clinical data, the therapy appears to be safe and feasible. Antiepileptic efficacy proved to be various; however, some abilities improved in all children. No signs of psychomotor regression were observed during the first year following the treatment.
Keyphrases
- cell therapy
- multiple sclerosis
- stem cells
- bone marrow
- induced apoptosis
- low dose
- clinical trial
- study protocol
- platelet rich plasma
- big data
- randomized controlled trial
- cell cycle arrest
- phase iii
- endoplasmic reticulum stress
- signaling pathway
- phase ii
- cell death
- artificial intelligence
- open label
- smoking cessation
- temporal lobe epilepsy