Predicting Functional Dependency in Patients with Disorders of Consciousness: A TBI-Model Systems and TRACK-TBI Study.
Samuel B SniderNancy R TemkinJason BarberBrian L EdlowJoseph T GiacinoFlora M HammondSaef IzzyRobert G KowalskiAmy J MarkowitzCraig A RovitoShirley L ShihRoss D ZafonteGeoffrey T ManleyYelena G Bodiennull nullPublished in: medRxiv : the preprint server for health sciences (2023)
We used the largest existing cohort of patients with DoC after TBI to develop, test and externally validate a prediction model of 1-year dependency. The model’s sensitivity and negative predictive value were greater than specificity and positive predictive value. Accuracy was diminished in an external sample, but equivalent to the best-available models. Further research is needed to improve dependency prediction in patients with DoC after TBI.