Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism.
Arash HaghikiaFriederike ZimmermannPaul SchumannAndrzej JasinaJohann RoesslerDavid SchmidtPhilipp HeinzeJohannes KaislerVanasa NageswaranAnnette AignerUta CeglarekRoodline CineusAhmed N HegazyEmiel P.C. van der VorstYvonne DöringChristopher M StrauchIna NemetValentina TremaroliChinmay DwibediNicolle KränkelDavid Manuel LeistnerMarkus M HeimesaatStefan BereswillGeraldine RauchUte SeelandOliver SoehnleinDominik N MüllerRalf GoldFredrik BäckhedStanley L HazenAiden HaghikiaUlf LandmesserPublished in: European heart journal (2021)
Our findings reveal a novel immune-mediated pathway linking the gut microbiota-derived metabolite PA with intestinal Npc1l1 expression and cholesterol homeostasis. The results highlight the gut immune system as a potential therapeutic target to control dyslipidaemia that may introduce a new avenue for prevention of ACVDs.