Higher levels of IgA and IgG at sepsis onset are associated with higher mortality: results from the Albumin Italian Outcome Sepsis (ALBIOS) trial.
Laura AlagnaJennifer M T A MeessenGiacomo BellaniDaniela AlbieroPietro CaironiIrene PrincipaleLuigi VivonaGiacomo GrasselliFrancesca MottaNicolò M AgnelliVieri ParriniStefano RomagnoliRoberto KeimFrancesca Di Marzo CapozziFabio S TacconeWalter TacconeBarbara BottazziAlessandra BanderaAndrea CortegianiRoberto LatiniPublished in: Annals of intensive care (2021)
In the largest cohort study of patients with severe sepsis or septic shock, we found that high levels of IgA and IgG on the first day of diagnosis were associated with a decreased 90-day survival. No association was found between IgM levels and survival. As such, the assessment of endogenous immunoglobulins could be a useful tool to identify septic patients at high risk of mortality. Trial registration #NCT00707122, Clinicaltrial.gov, registered 30 June 2008.