Early versus late start of direct oral anticoagulants after acute ischaemic stroke linked to atrial fibrillation: an observational study and individual patient data pooled analysis.
Gian Marco De MarchisDavid Julian SeiffgeSabine SchaedelinDuncan WilsonValeria CasoMonica AcciarresiGeorgios TsivgoulisMasatoshi KogaSohei YoshimuraKazunori ToyodaManuel CappellariBruno BonettiKosmas MachaBernd KallmünzerCarlo W CeredaPhilippe LyrerLeo H BonatiMaurizio PaciaroniStefan T EngelterDavid John WerringPublished in: Journal of neurology, neurosurgery, and psychiatry (2021)
Our results do not corroborate concerns that an early DOAC-start might excessively increase the risk of ICH. The sevenfold higher risk of recurrent AIS than ICH suggests that an early DOAC-start might be reasonable, supporting enrolment into randomised trials comparing an early versus late DOAC-start.
Keyphrases
- direct oral anticoagulants
- atrial fibrillation
- venous thromboembolism
- clinical trial
- oral anticoagulants
- left atrial
- left atrial appendage
- catheter ablation
- open label
- heart failure
- case report
- health insurance
- study protocol
- percutaneous coronary intervention
- randomized controlled trial
- acute coronary syndrome
- machine learning
- double blind
- deep learning
- left ventricular
- placebo controlled