Sodium chloride or Plasmalyte-148 evaluation in severe diabetic ketoacidosis (SCOPE-DKA): a cluster, crossover, randomized, controlled trial.

Mahesh RamananAntony AttokaranLauren MurrayNeeraj BhadangeDavid StewartGokulnath RajendranRaju PusapatiMelissa PettyPeter GarrettPeter KrugerSandra PeakeLaurent BillotBalasubramanian Venkateshnull null

Published in: Intensive care medicine (2021)

Plasmalyte-148, compared to sodium chloride 0.9%, may lead to faster resolution of metabolic acidosis in patients with DKA without an increase in ketosis. These findings need confirmation in a large, Phase 3 trial.

Keyphrases

randomized controlled trial
study protocol
type diabetes
early onset
wound healing
double blind
clinical trial
placebo controlled