Inflammatory Responses in Oro-Maxillofacial Region Expanded Using Anisotropic Hydrogel Tissue Expander.
Kholoud Mohamed Ali SalimAminah Abd JalilZamri RadziSiti Mazlipah IsmailJan T CzernuszkaMohammad Tariqur RahmanPublished in: Materials (Basel, Switzerland) (2020)
IL-1-α expression was only observed in the expanded tissue samples compared to the controls. In contrast, there was no significant difference in IL-6, and TNF-α production. Histological analysis showed the absence of inflammatory response in expanded tissues, and a negative non-significant correlation (Spearman's correlation coefficient) between IL-1-α immune-positive cells and the inflammatory cells (r = -0.500). In conclusion, tissues that are expanded and stabilized using an anisotropic self-inflating hydrogel tissue expander might be useful for tissue replacement and engraftment as the expanded tissue does not show any sign of inflammatory responses. Detection of IL-1-α in the expanded tissues warrants further investigation for its involvement without any visible inflammatory response.
Keyphrases
- inflammatory response
- induced apoptosis
- gene expression
- drug delivery
- rheumatoid arthritis
- oxidative stress
- poor prognosis
- endoplasmic reticulum stress
- immune response
- cell death
- signaling pathway
- toll like receptor
- wound healing
- lps induced
- cell proliferation
- diffusion weighted imaging
- cord blood
- hematopoietic stem cell