Intratumoral Injection of Clostridium novyi-NT Spores in Patients with Treatment-refractory Advanced Solid Tumors.

Filip JankuHalle Huihong ZhangAbdulmohammad PezeshkiSanjay GoelRavi MurthyAndrea Wang-GillamDale R ShepardThorunn HelgasonTyler MastersDavid S HongSarina A Piha-PaulDaniel D KarpMark G KlangSteven Y HuangDivya SakamuriAnjali RainaJean TorrisiStephen B SolomonAlice WeissfeldErnest TrevinoGary DeCrescenzoAmanda CollinsMaria MillerJennifer L SalstromRonald L KornLinping ZhangSaurabh SahaAlexey A LeontovichDavid TungBrent L KreiderMary VarterasianKhashayarsha KhazaieMrinal M Gounder

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Single intratumoral injection of C. novyi-NT is feasible. Toxicities can be significant but manageable. Signals of antitumor activity and the host immune response support additional studies of C. novyi-NT in humans.

Keyphrases

immune response
ultrasound guided
case control
inflammatory response
replacement therapy
smoking cessation